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    Ap3m2 adaptor related protein complex 3 subunit mu 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140667, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ap3m2provided by RGD
    Official Full Name
    adaptor related protein complex 3 subunit mu 2provided by RGD
    Primary source
    RGD:70969
    See related
    EnsemblRapid:ENSRNOG00000018650 AllianceGenome:RGD:70969
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in anterograde synaptic vesicle transport and synaptic vesicle endocytosis. Is active in synaptic vesicle. Orthologous to human AP3M2 (adaptor related protein complex 3 subunit mu 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 197.4), Spleen (RPKM 50.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ap3m2 in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (75908459..75937915)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (69217526..69237372)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (74075842..74091230)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene lysine acetyltransferase 6A Neighboring gene K(lysine) acetyltransferase 6A like Neighboring gene uncharacterized LOC120097529 Neighboring gene uncharacterized LOC134482521 Neighboring gene plasminogen activator, tissue type Neighboring gene glyceraldehyde-3-phosphate dehydrogenase-like Neighboring gene inhibitor of nuclear factor kappa B kinase subunit beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning of rodent megsin revealed its up-regulation in mesangioproliferative nephritis. Nangaku M, et al. Kidney Int, 2001 Aug. PMID 11473647
    2. Two rat homologs of clathrin-associated adaptor proteins. Pevsner J, et al. Gene, 1994 Sep 2. PMID 8076832
    3. Hidden proteome of synaptic vesicles in the mammalian brain. Taoufiq Z, et al. Proc Natl Acad Sci U S A, 2020 Dec 29. PMID 33376223, Free PMC Article
    4. The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse. Larimore J, et al. Mol Biol Cell, 2011 Dec. PMID 21998198, Free PMC Article
    5. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93230

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in anterograde axonal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in anterograde axonal transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in anterograde synaptic vesicle transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in anterograde synaptic vesicle transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in anterograde synaptic vesicle transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in neurotransmitter secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in GABA-ergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic vesicle EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    AP-3 complex subunit mu-2
    Names
    HA1 47 kDa subunit homolog 2
    P47B
    adapter-related protein complex 3 mu-2 subunit
    adapter-related protein complex 3 subunit mu-2
    adaptor-related protein complex 3, mu 2 subunit
    clathrin assembly protein assembly protein complex 1 medium chain homolog 2
    clathrin assembly protein assembly protein complex 3 mu-2 medium chain
    clathrin coat assembly protein AP47 homolog 2
    clathrin coat-associated protein AP47 homolog 2
    golgi adaptor AP-1 47 kDa protein homolog 2
    mu3B-adaptin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133305.2 → NP_579839.1  AP-3 complex subunit mu-2

      See identical proteins and their annotated locations for NP_579839.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086993
      UniProtKB/Swiss-Prot
      P53678
      UniProtKB/TrEMBL
      A6IW52, V9GZ82
      Conserved Domains (2) summary
      cd14837
      Location:3 → 141
      AP3_Mu_N; AP-3 complex subunit mu N-terminal domain
      cl10970
      Location:165 → 418
      AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      75908459..75937915
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094175.2 → XP_038950103.1  AP-3 complex subunit mu-2 isoform X1

      UniProtKB/Swiss-Prot
      P53678
      UniProtKB/TrEMBL
      A6IW52, V9GZ82
      Related
      ENSRNOP00000025675.5, ENSRNOT00000025675.7
      Conserved Domains (2) summary
      cd14837
      Location:3 → 141
      AP3_Mu_N; AP-3 complex subunit mu N-terminal domain
      cl10970
      Location:165 → 418
      AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

    2. XM_039094177.2 → XP_038950105.1  AP-3 complex subunit mu-2 isoform X1

      UniProtKB/Swiss-Prot
      P53678
      UniProtKB/TrEMBL
      A6IW52, V9GZ82
      Conserved Domains (2) summary
      cd14837
      Location:3 → 141
      AP3_Mu_N; AP-3 complex subunit mu N-terminal domain
      cl10970
      Location:165 → 418
      AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

    3. XM_063275047.1 → XP_063131117.1  AP-3 complex subunit mu-2 isoform X1

      UniProtKB/Swiss-Prot
      P53678
      UniProtKB/TrEMBL
      A6IW52, V9GZ82
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53678.1 GenPept UniProtKB/Swiss-Prot:P53678

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials