Piezo2 piezo-type mechanosensitive ion channel component 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Piezo2provided by RGD
Official Full Name: piezo-type mechanosensitive ion channel component 2provided by RGD
Primary source: RGD:1582973
See related: EnsemblRapid:ENSRNOG00000038784 AllianceGenome:RGD:1582973
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fam38b; RGD1306866
Summary: Predicted to enable mechanosensitive monoatomic ion channel activity and monoatomic cation channel activity. Predicted to be involved in several processes, including cellular response to mechanical stimulus; detection of mechanical stimulus involved in sensory perception; and monoatomic cation transport. Predicted to be located in cuticular plate; neuronal cell body membrane; and stereocilium. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 3 and distal arthrogryposis type 5. Orthologous to human PIEZO2 (piezo type mechanosensitive ion channel component 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 132.6), Adrenal (RPKM 51.4) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 55

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (58738734..59115252, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (56468449..56844984, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (58353361..58728555, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Piezo2 Channel Upregulation is Involved in Mechanical Allodynia in CYP-Induced Cystitis Rats.
Title: Piezo2 Channel Upregulation is Involved in Mechanical Allodynia in CYP-Induced Cystitis Rats.
Upregulation of Piezo2 in the mesangial, renin, and perivascular mesenchymal cells of the kidney of Dahl salt-sensitive hypertensive rats and its reversal by esaxerenone.
Title: Upregulation of Piezo2 in the mesangial, renin, and perivascular mesenchymal cells of the kidney of Dahl salt-sensitive hypertensive rats and its reversal by esaxerenone.
Loss of lung microvascular endothelial Piezo2 expression impairs NO synthesis, induces EndMT, and is associated with pulmonary hypertension.
Title: Loss of lung microvascular endothelial Piezo2 expression impairs NO synthesis, induces EndMT, and is associated with pulmonary hypertension.
Significance of piezo-type mechanosensitive ion channel component 2 in premature ejaculation: An animal study.
Title: Significance of piezo-type mechanosensitive ion channel component 2 in premature ejaculation: An animal study.
The effect of IL-6/Piezo2 on the trigeminal neuropathic pain.
Title: The effect of IL-6/Piezo2 on the trigeminal neuropathic pain.
Piezo2 knock-down in dorsal root ganglia attenuated visceral sensation to innocuous stimuli in control rats and to both innocuous and noxious stimuli in rats with neonatal irritation. Data suggest a potential role of Piezo2 in the mediation of visceral sensation.
Title: The potential role of Piezo2 in the mediation of visceral sensation.
findings suggest that Piezo2-mediated mechanotransduction is regulated by SPMT in primary afferent neurons.
Title: Regulation of Piezo2 Mechanotransduction by Static Plasma Membrane Tension in Primary Afferent Neurons.
Piezo2 channels are preferentially located on Merkel cell processes, the membrane domains inaccessible by recording electrodes
Title: Piezo2 channel conductance and localization domains in Merkel cells of rat whisker hair follicles.
These findings revealed a GTP-dependent up-regulation of the function of piezo2 ion channels in dorsal root ganglion neurons.
Title: GTP-dependent run-up of Piezo2-type mechanically activated currents in rat dorsal root ganglion neurons.
Using rat whisker hair follicles, study shows that Merkel cells rather than Abeta-afferent nerve endings are primary sites of tactile transduction and identify the Piezo2 ion channel as the Merkel cell mechanical transducer. Piezo2 transduces tactile stimuli into Ca2+-action potentials in Merkel cells, which drive Abeta-afferent nerve endings to fire slowly adapting impulses.
Title: Merkel cells transduce and encode tactile stimuli to drive Aβ-afferent impulses.

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General gene information

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Markers

RH141033 (e-PCR)
- UniSTS:223033

BE106644 (e-PCR)
- UniSTS:246353

D18Rat41 (e-PCR)
- UniSTS:118463

AW533757 (e-PCR)
- UniSTS:246008

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mechanosensitive monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables mechanosensitive monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info
enables monoatomic cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to mechanical stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of mechanical stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of mechanical stimulus involved in sensory perception	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic cation transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in response to mechanical stimulus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cuticular plate	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in stereocilium	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: piezo-type mechanosensitive ion channel component 2

Names: family with sequence similarity 38, member B; protein PIEZO2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427318.1 → NP_001414247.1 piezo-type mechanosensitive ion channel component 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

F1M208

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

58738734..59115252 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063277327.1 → XP_063133397.1 piezo-type mechanosensitive ion channel component 2 isoform X7

UniProtKB/TrEMBL

F1M208
XM_039097390.2 → XP_038953318.1 piezo-type mechanosensitive ion channel component 2 isoform X3

UniProtKB/TrEMBL

F1M208

Related

ENSRNOP00000084685.2, ENSRNOT00000107888.2

Conserved Domains (2) summary

pfam12166
Location:2378 → 2787

Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain

pfam15917
Location:1349 → 1583

PIEZO; Piezo
XM_039097388.2 → XP_038953316.1 piezo-type mechanosensitive ion channel component 2 isoform X1

UniProtKB/TrEMBL

A0A8I5ZZN0

Conserved Domains (2) summary

pfam12166
Location:2397 → 2806

Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain

pfam15917
Location:1368 → 1602

PIEZO; Piezo
XM_225880.11 → XP_225880.5 piezo-type mechanosensitive ion channel component 2 isoform X5

See identical proteins and their annotated locations for XP_225880.5

UniProtKB/TrEMBL

A0A8I5ZZN0, A0A8I6A0I2

Related

ENSRNOP00000025552.4, ENSRNOT00000025556.7

Conserved Domains (2) summary

pfam12166
Location:2340 → 2749

Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain

pfam15917
Location:1367 → 1598

PIEZO; Piezo
XM_039097389.2 → XP_038953317.1 piezo-type mechanosensitive ion channel component 2 isoform X2

UniProtKB/TrEMBL

A0A8I5ZZN0

Related

ENSRNOP00000085065.2, ENSRNOT00000102225.2

Conserved Domains (2) summary

pfam12166
Location:2396 → 2805

Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain

pfam15917
Location:1367 → 1601

PIEZO; Piezo
XM_039097391.2 → XP_038953319.1 piezo-type mechanosensitive ion channel component 2 isoform X4

UniProtKB/TrEMBL

F1M208

Related

ENSRNOP00000063723.4, ENSRNOT00000065693.6

Conserved Domains (2) summary

pfam12166
Location:2354 → 2763

Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain

pfam15917
Location:1381 → 1615

PIEZO; Piezo
XM_039097392.2 → XP_038953320.1 piezo-type mechanosensitive ion channel component 2 isoform X6

Conserved Domains (2) summary

pfam12166
Location:1514 → 1923

Piezo_RRas_bdg; Piezo non-specific cation channel, R-Ras-binding domain

pfam15917
Location:485 → 719

PIEZO; Piezo