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    Camk1g calcium/calmodulin-dependent protein kinase IG [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171358, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Camk1gprovided by RGD
    Official Full Name
    calcium/calmodulin-dependent protein kinase IGprovided by RGD
    Primary source
    RGD:621800
    See related
    EnsemblRapid:ENSRNOG00000006470 AllianceGenome:RGD:621800
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables calcium/calmodulin-dependent protein kinase activity. Involved in protein phosphorylation. Predicted to be located in endomembrane system and plasma membrane. Predicted to be part of calcium- and calmodulin-dependent protein kinase complex. Predicted to be active in cytoplasm. Orthologous to human CAMK1G (calcium/calmodulin dependent protein kinase IG). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 51.1), Lung (RPKM 8.2) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Camk1g in Genome Data Viewer
    Location:
    13q27
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (107406583..107430332, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (104877909..104901658, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (112075689..112099472, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene G0/G1switch 2 Neighboring gene laminin subunit beta 3 Neighboring gene microRNA 205 Neighboring gene uncharacterized LOC120096361

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning, characterization and expression of two alternatively splicing isoforms of Ca2+/calmodulin-dependent protein kinase I gamma in the rat brain. Nishimura H, et al. J Neurochem, 2003 Jun. PMID 12753081
    2. Transient receptor potential canonical 5 channels activate Ca2+/calmodulin kinase Igamma to promote axon formation in hippocampal neurons. Davare MA, et al. J Neurosci, 2009 Aug 5. PMID 19657032, Free PMC Article
    3. Isolation and comparison of rat cDNAs encoding Ca2+/calmodulin-dependent protein kinase I isoforms. Yokokura H, et al. Biochim Biophys Acta, 1997 Mar 7. PMID 9074610
    4. Molecular cloning and characterization of CLICK-III/CaMKIgamma, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK). Takemoto-Kimura S, et al. J Biol Chem, 2003 May 16. PMID 12637513
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results are consistent with a model in which highly localized calcium influx through the TRPC5 channels activates CaMKK and CaMKI, which subsequently promote axon formation.
      Title: Transient receptor potential canonical 5 channels activate Ca2+/calmodulin kinase Igamma to promote axon formation in hippocampal neurons.
    2. findings suggest that both alternatively splicing isoforms of CaMKI gamma may be involved in Ca2+ signal transduction in the cytoplasmic compartment of certain neuronal population
      Title: Cloning, characterization and expression of two alternatively splicing isoforms of Ca2+/calmodulin-dependent protein kinase I gamma in the rat brain.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium/calmodulin-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of calcium- and calmodulin-dependent protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endomembrane system ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    calcium/calmodulin-dependent protein kinase type 1G
    Names
    CLICK III
    caM kinase I gamma
    caM kinase IG
    caM-KI gamma
    caMK-like CREB kinase III
    caMKI gamma
    caMKIG
    calcium/calmodulin-dependent protein kinase I gamma
    NP_878262.1
    XP_006250532.1
    XP_063128062.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429714.1 → NP_001416643.1  calcium/calmodulin-dependent protein kinase type 1G isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6JH31

    2. NM_182842.1 → NP_878262.1  calcium/calmodulin-dependent protein kinase type 1G isoform 1

      See identical proteins and their annotated locations for NP_878262.1

      Status: PROVISIONAL

      Source sequence(s)
      AB101231
      UniProtKB/Swiss-Prot
      O08763, Q7TNJ6, Q7TNJ7
      UniProtKB/TrEMBL
      A6JH32
      Related
      ENSRNOP00000009158.3, ENSRNOT00000009158.8
      Conserved Domains (2) summary
      smart00220
      Location:23 → 277
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14166
      Location:19 → 303
      STKc_CaMKI_gamma; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I gamma

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      107406583..107430332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250470.4 → XP_006250532.1  calcium/calmodulin-dependent protein kinase type 1G isoform X2

      Related
      ENSRNOP00000041124.2, ENSRNOT00000044161.4
      Conserved Domains (2) summary
      smart00220
      Location:23 → 277
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14166
      Location:19 → 303
      STKc_CaMKI_gamma; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I gamma

    2. XM_063271992.1 → XP_063128062.1  calcium/calmodulin-dependent protein kinase type 1G isoform X1

      UniProtKB/Swiss-Prot
      O08763, Q7TNJ6, Q7TNJ7
      UniProtKB/TrEMBL
      A6JH32
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TNJ7.1 GenPept UniProtKB/Swiss-Prot:Q7TNJ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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