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    ARHGAP27 Rho GTPase activating protein 27 [ Homo sapiens (human) ]

    Gene ID: 201176, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ARHGAP27provided by HGNC
    Official Full Name
    Rho GTPase activating protein 27provided by HGNC
    Primary source
    HGNC:HGNC:31813
    See related
    Ensembl:ENSG00000159314 MIM:610591; AllianceGenome:HGNC:31813
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PP905; SH3D20; SH3P20; CAMGAP1
    Summary
    This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may pay a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2013]
    Expression
    Ubiquitous expression in esophagus (RPKM 12.5), spleen (RPKM 12.5) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ARHGAP27 in Genome Data Viewer
    Location:
    17q21.31
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (45393908..45432870, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (46247641..46286582, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (43471274..43510236, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 443 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:43414932-43415093 Neighboring gene OCT4 hESC enhancer GRCh37_chr17:43427135-43427636 Neighboring gene uncharacterized LOC105371796 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:43448585-43449784 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43450691-43451263 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43451264-43451835 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:43453675-43454480 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43462245-43463212 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43471827-43472486 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:43473118-43473275 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43488992-43489492 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43501082-43501588 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43501589-43502093 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43502838-43503408 Neighboring gene uncharacterized LOC124904016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43507020-43507520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43507521-43508021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43513205-43513858 Neighboring gene pleckstrin homology and RUN domain containing M1 Neighboring gene uncharacterized LOC124904113 Neighboring gene microRNA 4315-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of ARHGAP27 gene in silico. Katoh Y, et al. Int J Mol Med, 2004 Nov. PMID 15492870
    2. Identification and characterization of a novel Rho GTPase activating protein implicated in receptor-mediated endocytosis. Sakakibara T, et al. FEBS Lett, 2004 May 21. PMID 15147912
    3. Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships. Peck J, et al. FEBS Lett, 2002 Sep 25. PMID 12297274
    4. Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. Edwards TL, et al. Ann Hum Genet, 2010 Mar. PMID 20070850, Free PMC Article
    5. Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants. Wistow G, et al. Mol Vis, 2002 Jun 15. PMID 12107413

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ35572, FLJ43547, FLJ76025, MGC78393, MGC120624

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
    		  
    enables SH3 domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein heterooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor-mediated endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		  
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 27
    Names
    CIN85-associated multi-domain-containing Rho GTPase-activating protein 1
    SH3 domain containing 20
    SH3 domain-containing protein 20
    rho-type GTPase-activating protein 27

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282290.2 → NP_001269219.1  rho GTPase-activating protein 27 isoform d

      See identical proteins and their annotated locations for NP_001269219.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (d).
      Source sequence(s)
      AC003070, AC091132
      Consensus CDS
      CCDS74082.1
      UniProtKB/Swiss-Prot
      A4FU35, A8K3N5, C9JTF3, Q494U0, Q6NWZ8, Q6ZUM4, Q8WY58
      UniProtKB/TrEMBL
      A0A0G2JNY3
      Related
      ENSP00000509127.1, ENST00000685559.1
      Conserved Domains (6) summary
      smart00456
      Location:417 → 443
      WW; Domain with 2 conserved Trp (W) residues
      cd12069
      Location:10 → 66
      SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
      cd04403
      Location:695 → 881
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:499 → 613
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:499 → 611
      PH; PH domain
      pfam00397
      Location:247 → 278
      WW; WW domain

    2. NM_001385384.1 → NP_001372313.1  rho GTPase-activating protein 27 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC003070, AC091132
      Consensus CDS
      CCDS92343.1
      UniProtKB/TrEMBL
      A0A0G2JRG8, E9PIR1
      Related
      ENST00000531735.5
      Conserved Domains (5) summary
      cd12069
      Location:10 → 66
      SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
      COG5104
      Location:239 → 376
      PRP40; Splicing factor [RNA processing and modification]
      cd04403
      Location:673 → 859
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:477 → 591
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:247 → 278
      WW; WW domain

    3. NM_001385385.1 → NP_001372314.1  rho GTPase-activating protein 27 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC003070
      Consensus CDS
      CCDS92341.1
      UniProtKB/TrEMBL
      A0A8I5KVA8
      Related
      ENSP00000508575.1, ENST00000691061.1
      Conserved Domains (4) summary
      COG5104
      Location:39 → 176
      PRP40; Splicing factor [RNA processing and modification]
      cd04403
      Location:495 → 681
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:299 → 413
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:47 → 78
      WW; WW domain

    4. NM_001385386.1 → NP_001372315.1  rho GTPase-activating protein 27 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC003070
      Conserved Domains (4) summary
      COG5104
      Location:39 → 176
      PRP40; Splicing factor [RNA processing and modification]
      cd04403
      Location:478 → 664
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:277 → 391
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:47 → 78
      WW; WW domain

    5. NM_001385387.1 → NP_001372316.1  rho GTPase-activating protein 27 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC003070
      Consensus CDS
      CCDS92340.1
      UniProtKB/TrEMBL
      E9PNT2
      Related
      ENSP00000432762.1, ENST00000532038.5
      Conserved Domains (4) summary
      COG5104
      Location:39 → 176
      PRP40; Splicing factor [RNA processing and modification]
      cd04403
      Location:473 → 659
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:277 → 391
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:47 → 78
      WW; WW domain

    6. NM_001385388.1 → NP_001372317.1  rho GTPase-activating protein 27 isoform i

      Status: VALIDATED

      Source sequence(s)
      AC003070
      Conserved Domains (4) summary
      COG5104
      Location:39 → 176
      PRP40; Splicing factor [RNA processing and modification]
      cd13233
      Location:277 → 391
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:47 → 78
      WW; WW domain
      cl02570
      Location:473 → 633
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    7. NM_001385389.1 → NP_001372318.1  rho GTPase-activating protein 27 isoform j

      Status: VALIDATED

      Source sequence(s)
      AC003070
      Conserved Domains (4) summary
      COG5104
      Location:39 → 176
      PRP40; Splicing factor [RNA processing and modification]
      cd13233
      Location:299 → 413
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:47 → 78
      WW; WW domain
      cl02570
      Location:495 → 595
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    8. NM_001385390.1 → NP_001372319.1  rho GTPase-activating protein 27 isoform k

      Status: VALIDATED

      Source sequence(s)
      AC003070
      Consensus CDS
      CCDS92342.1
      UniProtKB/TrEMBL
      E9PNX6
      Related
      ENSP00000437100.2, ENST00000528677.2
      Conserved Domains (4) summary
      PRK08691
      Location:24 → 228
      PRK08691; DNA polymerase III subunits gamma and tau; Validated
      cd04403
      Location:438 → 624
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:242 → 356
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:47 → 78
      WW; WW domain

    9. NM_001385391.1 → NP_001372320.1  rho GTPase-activating protein 27 isoform l

      Status: VALIDATED

      Source sequence(s)
      AC003070
      Conserved Domains (4) summary
      PRK10263
      Location:13 → 245
      PRK10263; DNA translocase FtsK; Provisional
      cd04403
      Location:416 → 602
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:220 → 334
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:47 → 78
      WW; WW domain

    10. NM_001385392.1 → NP_001372321.1  rho GTPase-activating protein 27 isoform m

      Status: VALIDATED

      Source sequence(s)
      AC003070
      Conserved Domains (4) summary
      PRK10263
      Location:13 → 245
      PRK10263; DNA translocase FtsK; Provisional
      cd13233
      Location:220 → 334
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:47 → 78
      WW; WW domain
      cl02570
      Location:416 → 576
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    11. NM_001385393.1 → NP_001372322.1  rho GTPase-activating protein 27 isoform n

      Status: VALIDATED

      Source sequence(s)
      AC003070, AC091132
      UniProtKB/TrEMBL
      A0A0C4DGE6
      Conserved Domains (4) summary
      cd00201
      Location:52 → 82
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd04403
      Location:359 → 545
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:158 → 272
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:74 → 101
      WW; WW domain

    12. NM_001385394.1 → NP_001372323.1  rho GTPase-activating protein 27 isoform o

      Status: VALIDATED

      Source sequence(s)
      AC003070, AC091132
      UniProtKB/TrEMBL
      A0A0C4DGE6
      Related
      ENST00000703660.1
      Conserved Domains (4) summary
      cd00201
      Location:52 → 82
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd04403
      Location:332 → 518
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:136 → 250
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:74 → 101
      WW; WW domain

    13. NM_001385395.1 → NP_001372324.1  rho GTPase-activating protein 27 isoform p

      Status: VALIDATED

      Source sequence(s)
      AC003070, AC091132
      UniProtKB/TrEMBL
      A0A0C4DGE6
      Conserved Domains (4) summary
      cd00201
      Location:52 → 82
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd13233
      Location:158 → 272
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:74 → 101
      WW; WW domain
      cl02570
      Location:354 → 454
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    14. NM_001385396.1 → NP_001372325.1  rho GTPase-activating protein 27 isoform q

      Status: VALIDATED

      Source sequence(s)
      AC003070, AC091132
      UniProtKB/TrEMBL
      A0A0C4DGE6
      Conserved Domains (4) summary
      cd00201
      Location:52 → 82
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd04403
      Location:328 → 485
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:136 → 250
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00397
      Location:74 → 101
      WW; WW domain

    15. NM_001385397.1 → NP_001372326.1  rho GTPase-activating protein 27 isoform r

      Status: VALIDATED

      Source sequence(s)
      AC003070, AC091132
      UniProtKB/TrEMBL
      A0A0C4DGE6
      Conserved Domains (3) summary
      smart00456
      Location:12 → 38
      WW; Domain with 2 conserved Trp (W) residues
      cd04403
      Location:290 → 476
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:94 → 208
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

    16. NM_001385398.1 → NP_001372327.1  rho GTPase-activating protein 27 isoform s

      Status: VALIDATED

      Description
      Transcript Variant: This variant (19), as well as variant 20, encodes isoform s.
      Source sequence(s)
      AC003070, AC091132
      UniProtKB/TrEMBL
      A0A0C4DGE6
      Conserved Domains (3) summary
      smart00456
      Location:12 → 38
      WW; Domain with 2 conserved Trp (W) residues
      cd04403
      Location:268 → 454
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:72 → 186
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

    17. NM_001385399.1 → NP_001372328.1  rho GTPase-activating protein 27 isoform s

      Status: VALIDATED

      Description
      Transcript Variant: This variant (20), as well as variant 19, encodes isoform s.
      Source sequence(s)
      AC003070
      UniProtKB/TrEMBL
      A0A0C4DGE6
      Conserved Domains (3) summary
      smart00456
      Location:12 → 38
      WW; Domain with 2 conserved Trp (W) residues
      cd04403
      Location:268 → 454
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:72 → 186
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

    18. NM_174919.4 → NP_777579.2  rho GTPase-activating protein 27 isoform c

      See identical proteins and their annotated locations for NP_777579.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) is a short variant at the 5' end of a much longer ARHGAP27 gene, and differs in the UTRs and CDS compared to variant 4. The encoded isoform (c) is shorter than isoform d.
      Source sequence(s)
      AC091132
      Consensus CDS
      CCDS32670.1
      UniProtKB/TrEMBL
      A0A0G2JP16
      Related
      ENSP00000290470.3, ENST00000290470.3
      Conserved Domains (1) summary
      cd12069
      Location:10 → 66
      SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27

    19. NM_199282.3 → NP_954976.1  rho GTPase-activating protein 27 isoform a

      See identical proteins and their annotated locations for NP_954976.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is a short variant at the 3' end of a longer ARHGAP27 gene and differs in the 5' UTR and CDS compared to variant 4. The encoded isoform (a) is shorter than isoform d.
      Source sequence(s)
      AK125535, BC029634, BC101391, BX386761, CD675139
      Consensus CDS
      CCDS11498.1
      UniProtKB/TrEMBL
      A0A0C4DGE6
      Related
      ENSP00000366121.2, ENST00000376922.6
      Conserved Domains (5) summary
      smart00456
      Location:76 → 102
      WW; Domain with 2 conserved Trp (W) residues
      cd00201
      Location:52 → 82
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd04403
      Location:354 → 540
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:158 → 272
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:158 → 270
      PH; PH domain

    RNA

    1. NR_169600.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC003070, AC091132

    2. NR_169601.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC003070, AC091132

    3. NR_169602.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC003070, AC091132

    4. NR_169603.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC003070, AC091132

    5. NR_169604.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC003070, AC091132

    6. NR_169605.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC003070, AC091132

    7. NR_169606.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC003070, AC091132

    8. NR_169607.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC003070, AC091132

    9. NR_169608.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC003070, AC091132

    10. NR_169609.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC003070, AC091132

    11. NR_169610.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC003070

    12. NR_169611.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC003070

    13. NR_169612.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC003070

    14. NR_169613.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC003070

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      45393908..45432870 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047435547.1 → XP_047291503.1  rho GTPase-activating protein 27 isoform X4

    2. XM_047435546.1 → XP_047291502.1  rho GTPase-activating protein 27 isoform X3

    3. XM_011524468.2 → XP_011522770.1  rho GTPase-activating protein 27 isoform X1

      See identical proteins and their annotated locations for XP_011522770.1

      UniProtKB/TrEMBL
      A0A0G2JNY3
      Conserved Domains (6) summary
      smart00456
      Location:417 → 443
      WW; Domain with 2 conserved Trp (W) residues
      cd12069
      Location:10 → 66
      SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
      cd04403
      Location:728 → 914
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:499 → 613
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:499 → 611
      PH; PH domain
      pfam00397
      Location:247 → 278
      WW; WW domain

    4. XM_047435544.1 → XP_047291500.1  rho GTPase-activating protein 27 isoform X2

      UniProtKB/TrEMBL
      E9PIR1

    5. XM_047435543.1 → XP_047291499.1  rho GTPase-activating protein 27 isoform X10

      UniProtKB/Swiss-Prot
      A4FU35, A8K3N5, C9JTF3, Q494U0, Q6NWZ8, Q6ZUM4, Q8WY58

    6. XM_047435545.1 → XP_047291501.1  rho GTPase-activating protein 27 isoform X2

      UniProtKB/TrEMBL
      E9PIR1
      Related
      ENSP00000433942.1, ENST00000532891.6

    7. XM_011524474.2 → XP_011522776.1  rho GTPase-activating protein 27 isoform X8

      See identical proteins and their annotated locations for XP_011522776.1

      UniProtKB/TrEMBL
      A0A0C4DGE6
      Conserved Domains (5) summary
      smart00456
      Location:76 → 102
      WW; Domain with 2 conserved Trp (W) residues
      cd00201
      Location:52 → 82
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd04403
      Location:387 → 573
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:158 → 272
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:158 → 270
      PH; PH domain

    8. XM_047435550.1 → XP_047291506.1  rho GTPase-activating protein 27 isoform X7

    9. XM_047435548.1 → XP_047291504.1  rho GTPase-activating protein 27 isoform X6

    10. XM_011524472.3 → XP_011522774.1  rho GTPase-activating protein 27 isoform X5

      See identical proteins and their annotated locations for XP_011522774.1

      Conserved Domains (5) summary
      smart00456
      Location:217 → 243
      WW; Domain with 2 conserved Trp (W) residues
      cd04403
      Location:528 → 714
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:299 → 413
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:299 → 411
      PH; PH domain
      pfam00397
      Location:47 → 78
      WW; WW domain

    11. XM_047435551.1 → XP_047291507.1  rho GTPase-activating protein 27 isoform X9

    12. XM_047435549.1 → XP_047291505.1  rho GTPase-activating protein 27 isoform X11

    13. XM_006721750.5 → XP_006721813.1  rho GTPase-activating protein 27 isoform X12

      See identical proteins and their annotated locations for XP_006721813.1

      Conserved Domains (4) summary
      cd12069
      Location:10 → 66
      SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
      cd13233
      Location:499 → 613
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:499 → 611
      PH; PH domain
      pfam00397
      Location:247 → 278
      WW; WW domain

    14. XM_011524473.3 → XP_011522775.1  rho GTPase-activating protein 27 isoform X13

      See identical proteins and their annotated locations for XP_011522775.1

      Conserved Domains (3) summary
      cd12069
      Location:10 → 66
      SH3_ARHGAP27; Src Homology 3 domain of Rho GTPase-activating protein 27
      pfam00397
      Location:247 → 278
      WW; WW domain
      cl17171
      Location:499 → 582
      PH-like; Pleckstrin homology-like domain

    RNA

    1. XR_934416.3 RNA Sequence

    2. XR_001752447.2 RNA Sequence

    3. XR_007065283.1 RNA Sequence

    4. XR_001752448.2 RNA Sequence

    5. XR_007065286.1 RNA Sequence

    6. XR_007065284.1 RNA Sequence

    7. XR_007065285.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_167251.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      84429..123368 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328551.1 → XP_054184526.1  rho GTPase-activating protein 27 isoform X14

    2. XM_054328553.1 → XP_054184528.1  rho GTPase-activating protein 27 isoform X3

    3. XM_054328549.1 → XP_054184524.1  rho GTPase-activating protein 27 isoform X1

    4. XM_054328552.1 → XP_054184527.1  rho GTPase-activating protein 27 isoform X15

    5. XM_054328550.1 → XP_054184525.1  rho GTPase-activating protein 27 isoform X1

    6. XM_054328559.1 → XP_054184534.1  rho GTPase-activating protein 27 isoform X8

    7. XM_054328557.1 → XP_054184532.1  rho GTPase-activating protein 27 isoform X7

    8. XM_054328555.1 → XP_054184530.1  rho GTPase-activating protein 27 isoform X6

    9. XM_054328554.1 → XP_054184529.1  rho GTPase-activating protein 27 isoform X5

    10. XM_054328556.1 → XP_054184531.1  rho GTPase-activating protein 27 isoform X11

    11. XM_054328558.1 → XP_054184533.1  rho GTPase-activating protein 27 isoform X12

    RNA

    1. XR_008485590.1 RNA Sequence

    2. XR_008485593.1 RNA Sequence

    3. XR_008485592.1 RNA Sequence

    4. XR_008485591.1 RNA Sequence

    5. XR_008485595.1 RNA Sequence

    6. XR_008485597.1 RNA Sequence

    7. XR_008485594.1 RNA Sequence

    8. XR_008485596.1 RNA Sequence

    9. XR_008485598.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187663.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      84411..123375 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330093.1 → XP_054186068.1  rho GTPase-activating protein 27 isoform X4

    2. XM_054330092.1 → XP_054186067.1  rho GTPase-activating protein 27 isoform X3

    3. XM_054330088.1 → XP_054186063.1  rho GTPase-activating protein 27 isoform X1

    4. XM_054330089.1 → XP_054186064.1  rho GTPase-activating protein 27 isoform X10

      UniProtKB/Swiss-Prot
      A4FU35, A8K3N5, C9JTF3, Q494U0, Q6NWZ8, Q6ZUM4, Q8WY58

    5. XM_054330090.1 → XP_054186065.1  rho GTPase-activating protein 27 isoform X2

      UniProtKB/TrEMBL
      E9PIR1

    6. XM_054330091.1 → XP_054186066.1  rho GTPase-activating protein 27 isoform X2

      UniProtKB/TrEMBL
      E9PIR1

    7. XM_054330099.1 → XP_054186074.1  rho GTPase-activating protein 27 isoform X8

    8. XM_054330097.1 → XP_054186072.1  rho GTPase-activating protein 27 isoform X7

    9. XM_054330095.1 → XP_054186070.1  rho GTPase-activating protein 27 isoform X6

    10. XM_054330094.1 → XP_054186069.1  rho GTPase-activating protein 27 isoform X5

    11. XM_054330100.1 → XP_054186075.1  rho GTPase-activating protein 27 isoform X9

    12. XM_054330096.1 → XP_054186071.1  rho GTPase-activating protein 27 isoform X11

    13. XM_054330098.1 → XP_054186073.1  rho GTPase-activating protein 27 isoform X12

    RNA

    1. XR_008485674.1 RNA Sequence

    2. XR_008485676.1 RNA Sequence

    3. XR_008485675.1 RNA Sequence

    4. XR_008485678.1 RNA Sequence

    5. XR_008485680.1 RNA Sequence

    6. XR_008485677.1 RNA Sequence

    7. XR_008485679.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      46247641..46286582 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315355.1 → XP_054171330.1  rho GTPase-activating protein 27 isoform X4

    2. XM_054315354.1 → XP_054171329.1  rho GTPase-activating protein 27 isoform X3

    3. XM_054315352.1 → XP_054171327.1  rho GTPase-activating protein 27 isoform X1

    4. XM_054315353.1 → XP_054171328.1  rho GTPase-activating protein 27 isoform X2

    5. XM_054315359.1 → XP_054171334.1  rho GTPase-activating protein 27 isoform X8

    6. XM_054315358.1 → XP_054171333.1  rho GTPase-activating protein 27 isoform X7

    7. XM_054315357.1 → XP_054171332.1  rho GTPase-activating protein 27 isoform X6

    8. XM_054315356.1 → XP_054171331.1  rho GTPase-activating protein 27 isoform X5

    9. XM_054315360.1 → XP_054171335.1  rho GTPase-activating protein 27 isoform X9

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001159330.1: Suppressed sequence

      Description
      NM_001159330.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZUM4.3 GenPept UniProtKB/Swiss-Prot:Q6ZUM4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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