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    Polr1h RNA polymerase I subunit H [ Mus musculus (house mouse) ]

    Gene ID: 66136, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Polr1hprovided by MGI
    Official Full Name
    RNA polymerase I subunit Hprovided by MGI
    Primary source
    MGI:MGI:1913386
    See related
    Ensembl:ENSMUSG00000036315 AllianceGenome:MGI:1913386
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rpa12; Znrd1; 1110014N07Rik
    Summary
    Predicted to enable DNA-directed 5'-3' RNA polymerase activity; nucleic acid binding activity; and zinc ion binding activity. Predicted to contribute to RNA polymerase I activity. Predicted to be involved in termination of RNA polymerase I transcription. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase I complex. Is expressed in early conceptus; genitourinary system; and limb. Orthologous to human POLR1H (RNA polymerase I subunit H). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 18.1), CNS E11.5 (RPKM 17.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Polr1h in Genome Data Viewer
    Location:
    17 B1; 17 19.16 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (37265250..37269417, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (36954358..36958525, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 39 Neighboring gene predicted gene, 33595 Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 11 Neighboring gene STARR-positive B cell enhancer ABC_E7532 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:37088519-37088789 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:37095409-37095518 Neighboring gene RNA polymerase I subunit H, antisense Neighboring gene histocompatibility 2, M region locus 6, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in termination of RNA polymerase I transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase I complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase I complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase I subunit RPA12
    Names
    DNA-directed RNA polymerase I subunit H
    nuclear RNA polymerase I small specific subunit
    zinc ribbon domain containing 1
    zinc ribbon domain-containing protein 1
    NP_001342351.1
    NP_075651.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355422.1 → NP_001342351.1  DNA-directed RNA polymerase I subunit RPA12

      Status: VALIDATED

      Source sequence(s)
      CR956641
      Consensus CDS
      CCDS28730.1
      UniProtKB/Swiss-Prot
      Q791N7
      UniProtKB/TrEMBL
      G3UXD3
      Related
      ENSMUSP00000133651.2, ENSMUST00000172518.8
      Conserved Domains (2) summary
      cd10507
      Location:76 → 122
      Zn-ribbon_RPA12; C-terminal zinc ribbon domain of RPA12 subunit of RNA polymerase I
      cl27574
      Location:17 → 46
      OrfB_Zn_ribbon; Putative transposase DNA-binding domain

    2. NM_023162.4 → NP_075651.1  DNA-directed RNA polymerase I subunit RPA12

      See identical proteins and their annotated locations for NP_075651.1

      Status: VALIDATED

      Source sequence(s)
      AK003714
      Consensus CDS
      CCDS28730.1
      UniProtKB/Swiss-Prot
      Q791N7
      UniProtKB/TrEMBL
      G3UXD3
      Related
      ENSMUSP00000109299.3, ENSMUST00000113669.9
      Conserved Domains (2) summary
      cd10507
      Location:76 → 122
      Zn-ribbon_RPA12; C-terminal zinc ribbon domain of RPA12 subunit of RNA polymerase I
      cl27574
      Location:17 → 46
      OrfB_Zn_ribbon; Putative transposase DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      37265250..37269417 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q791N7.1 GenPept UniProtKB/Swiss-Prot:Q791N7

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