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    TCL6 T cell leukemia/lymphoma 6 [ Homo sapiens (human) ]

    Gene ID: 27004, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TCL6provided by HGNC
    Official Full Name
    T cell leukemia/lymphoma 6provided by HGNC
    Primary source
    HGNC:HGNC:13463
    See related
    MIM:604412; AllianceGenome:HGNC:13463
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TNG1; TNG2
    Expression
    Biased expression in kidney (RPKM 2.4), placenta (RPKM 1.4) and 5 other tissues See more
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    Genomic context

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    See TCL6 in Genome Data Viewer
    Location:
    14q32.13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (95652097..95673452)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (89883670..89905022)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (96118434..96139789)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:96042156-96043078 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:96043079-96044000 Neighboring gene long intergenic non-protein coding RNA 2318 Neighboring gene uncharacterized LOC105370643 Neighboring gene Sharpr-MPRA regulatory region 452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8968 Neighboring gene uncharacterized LOC124903372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96131757-96132404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:96133051-96133697 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8969 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8971 Neighboring gene TCL1 family AKT coactivator B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8972 Neighboring gene uncharacterized LOC124903373

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Downregulation of TCL6 protected human trophoblast cells from LPS-induced inflammation and ferroptosis. Wang Y, et al. Funct Integr Genomics, 2023 Jul 8. PMID 37420113
    2. Decreased TCL6 expression is associated with poor prognosis in patients with clear cell renal cell carcinoma. Su H, et al. Oncotarget, 2017 Jan 24. PMID 27494890, Free PMC Article
    3. LncRNA-TCL6 promotes early abortion and inhibits placenta implantation via the EGFR pathway. Liu LP, et al. Eur Rev Med Pharmacol Sci, 2018 Nov. PMID 30468451
    4. Overexpression of lncRNA TCL6 promotes preeclampsia progression by regulating PTEN. Wu JL, et al. Eur Rev Med Pharmacol Sci, 2019 May. PMID 31173275
    5. Expression of the long non-coding RNA TCL6 is associated with clinical outcome in pediatric B-cell acute lymphoblastic leukemia. Cuadros M, et al. Blood Cancer J, 2019 Nov 25. PMID 31767830, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Association between expression levels of p53, miRNA-21, and lncRNA-TCL6 and the risk of preeclampsia in pregnant women.
      Title: Association between expression levels of p53, miRNA-21, and lncRNA-TCL6 and the risk of preeclampsia in pregnant women.
    2. Downregulation of TCL6 protected human trophoblast cells from LPS-induced inflammation and ferroptosis.
      Title: Downregulation of TCL6 protected human trophoblast cells from LPS-induced inflammation and ferroptosis.
    3. Long non-coding RNA TCL6 induced by SCRT1 promotes proliferation and metastasis of non-small cell lung cancer through PDK1/AKT signaling.
      Title: Long non-coding RNA TCL6 induced by SCRT1 promotes proliferation and metastasis of non-small cell lung cancer through PDK1/AKT signaling.
    4. A lncRNA TCL6-miR-155 Interaction Regulates the Src-Akt-EMT Network to Mediate Kidney Cancer Progression and Metastasis.
      Title: A lncRNA TCL6-miR-155 Interaction Regulates the Src-Akt-EMT Network to Mediate Kidney Cancer Progression and Metastasis.
    5. Long noncoding RNA TCL6 binds to miR-106a-5p to regulate hepatocellular carcinoma cells through PI3K/AKT signaling pathway.
      Title: Long noncoding RNA TCL6 binds to miR-106a-5p to regulate hepatocellular carcinoma cells through PI3K/AKT signaling pathway.
    6. lncRNA TCL6 correlates with immune cell infiltration and indicates worse survival in breast cancer.
      Title: lncRNA TCL6 correlates with immune cell infiltration and indicates worse survival in breast cancer.
    7. Overexpression of lncRNA TCL6 promotes preeclampsia progression by regulating PTEN.
      Title: Overexpression of lncRNA TCL6 promotes preeclampsia progression by regulating PTEN.
    8. we have identified TCL6 as a novel lncRNA strongly related to ETV6-RUNX1-positive pediatric B-ALL. We suggest that low TCL6 levels may be associated with poor disease-free survival, even within ETV6-RUNX1-positive B-ALL
      Title: Expression of the long non-coding RNA TCL6 is associated with clinical outcome in pediatric B-cell acute lymphoblastic leukemia.
    9. LncRNA-TCL6 promotes early abortion and inhibits placenta implantation via the EGFR pathway
      Title: LncRNA-TCL6 promotes early abortion and inhibits placenta implantation via the EGFR pathway.
    10. Results show decreased TCL6 expression in clear cell renal cell carcinoma (ccRCC), associated with poor prognosis and that its overexpression in 786-O and Caki-1 ccRCC cells decreased proliferation and increased apoptosis.
      Title: Decreased TCL6 expression is associated with poor prognosis in patients with clear cell renal cell carcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Leukemia/lymphoma, T-cell
    MedGen: CN375895 GeneReviews: Not available
    		not available

    EBI GWAS Catalog

    Description
    A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: TCL1B

    Other Names

    • T cell leukemia/lymphoma 6 (non-protein coding)
    • TCL1-neighboring gene 1
    • TCL1-neighboring gene 2

    Clone Names

    • FLJ13652

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_028288.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL133467

    2. NR_152604.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL133467

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      95652097..95673452
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      89883670..89905022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_012468.4: Suppressed sequence

      Description
      NM_012468.4: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.

    2. NM_014418.3: Suppressed sequence

      Description
      NM_014418.3: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.

    3. NM_020550.3: Suppressed sequence

      Description
      NM_020550.3: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.

    4. NM_020552.3: Suppressed sequence

      Description
      NM_020552.3: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.

    5. NM_020553.3: Suppressed sequence

      Description
      NM_020553.3: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.

    6. NM_020554.3: Suppressed sequence

      Description
      NM_020554.3: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version

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