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    SIGLEC9 sialic acid binding Ig like lectin 9 [ Homo sapiens (human) ]

    Gene ID: 27180, updated on 27-Nov-2024

    Summary

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    Official Symbol
    SIGLEC9provided by HGNC
    Official Full Name
    sialic acid binding Ig like lectin 9provided by HGNC
    Primary source
    HGNC:HGNC:10878
    See related
    Ensembl:ENSG00000129450 MIM:605640; AllianceGenome:HGNC:10878
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD329; CDw329; FOAP-9; siglec-9; OBBP-LIKE
    Summary
    Predicted to enable monosaccharide binding activity and sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within negative regulation of inflammatory response and negative regulation of phagocytosis, engulfment. Predicted to be located in external side of plasma membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in appendix (RPKM 3.6), spleen (RPKM 2.9) and 15 other tissues See more
    Orthologs
    all
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    Genomic context

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    See SIGLEC9 in Genome Data Viewer
    Location:
    19q13.41
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51119778..51136263)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54211244..54230912)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51628137..51639520)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1105 Neighboring gene kallikrein related peptidase 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15008 Neighboring gene cytosolic thiouridylase subunit 1 Neighboring gene sialic acid binding Ig like lectin 18, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15009 Neighboring gene uncharacterized LOC124904749 Neighboring gene sialic acid binding Ig like lectin 7 Neighboring gene uncharacterized LOC101928517

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression of Siglec-9 in peripheral blood neutrophils was increased and associated with disease severity in patients with AECOPD. Ge L, et al. Cytokine, 2024 May. PMID 38412768
    2. Binding of a sialic acid-recognizing lectin Siglec-9 modulates adhesion dynamics of cancer cells via calpain-mediated protein degradation. Sabit I, et al. J Biol Chem, 2013 Dec 6. PMID 24145038, Free PMC Article
    3. Siglec-9 transduces apoptotic and nonapoptotic death signals into neutrophils depending on the proinflammatory cytokine environment. von Gunten S, et al. Blood, 2005 Aug 15. PMID 15827126
    4. Influence of SIGLEC9 polymorphisms on COPD phenotypes including exacerbation frequency. Ishii T, et al. Respirology, 2017 May. PMID 27878892
    5. Immunomodulation of monocyte-derived dendritic cells through ligation of tumor-produced mucins to Siglec-9. Ohta M, et al. Biochem Biophys Res Commun, 2010 Nov 26. PMID 20971061

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis.
      Title: The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis.
    2. Expression of Siglec-9 in peripheral blood neutrophils was increased and associated with disease severity in patients with AECOPD.
      Title: Expression of Siglec-9 in peripheral blood neutrophils was increased and associated with disease severity in patients with AECOPD.
    3. The change of Siglec-9 expression in peripheral blood NK cells of SFTS patients can affect the function of NK cells.
      Title: The change of Siglec-9 expression in peripheral blood NK cells of SFTS patients can affect the function of NK cells.
    4. Siglec-9 acts as an immune-checkpoint molecule on macrophages in glioblastoma, restricting T-cell priming and immunotherapy response.
      Title: Siglec-9 acts as an immune-checkpoint molecule on macrophages in glioblastoma, restricting T-cell priming and immunotherapy response.
    5. LINC01004-SPI1 axis-activated SIGLEC9 in tumor-associated macrophages induces radioresistance and the formation of immunosuppressive tumor microenvironment in esophageal squamous cell carcinoma.
      Title: LINC01004-SPI1 axis-activated SIGLEC9 in tumor-associated macrophages induces radioresistance and the formation of immunosuppressive tumor microenvironment in esophageal squamous cell carcinoma.
    6. Siglec-9 Restrains Antibody-Dependent Natural Killer Cell Cytotoxicity against SARS-CoV-2.
      Title: Siglec-9 Restrains Antibody-Dependent Natural Killer Cell Cytotoxicity against SARS-CoV-2.
    7. Identification and validation of a siglec-based and aging-related 9-gene signature for predicting prognosis in acute myeloid leukemia patients.
      Title: Identification and validation of a siglec-based and aging-related 9-gene signature for predicting prognosis in acute myeloid leukemia patients.
    8. Modulation of immune cell reactivity with cis-binding Siglec agonists.
      Title: Modulation of immune cell reactivity with cis-binding Siglec agonists.
    9. The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression.
      Title: The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression.
    10. Targeting glycosylated antigens on cancer cells using siglec-7/9-based CAR T-cells.
      Title: Targeting glycosylated antigens on cancer cells using siglec-7/9-based CAR T-cells.
    Submit: New GeneRIF Correction See all GeneRIFs (44)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables carbohydrate binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sialic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    sialic acid-binding Ig-like lectin 9
    Names
    protein FOAP-9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198558.1 → NP_001185487.1  sialic acid-binding Ig-like lectin 9 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001185487.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK297043, BP305376
      Consensus CDS
      CCDS56100.1
      UniProtKB/Swiss-Prot
      Q9Y336
      Related
      ENSP00000413861.2, ENST00000440804.7
      Conserved Domains (3) summary
      cd05712
      Location:23 → 140
      Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
      smart00410
      Location:258 → 336
      IG_like; Immunoglobulin like
      cl11960
      Location:151 → 222
      Ig; Immunoglobulin domain

    2. NM_014441.3 → NP_055256.1  sialic acid-binding Ig-like lectin 9 isoform 2 precursor

      See identical proteins and their annotated locations for NP_055256.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate 3' terminal coding exon, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC011473
      Consensus CDS
      CCDS12825.1
      UniProtKB/Swiss-Prot
      Q6GTU4, Q9BYI9, Q9Y336
      Related
      ENSP00000250360.2, ENST00000250360.8
      Conserved Domains (3) summary
      cd05712
      Location:23 → 140
      Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
      smart00410
      Location:258 → 336
      IG_like; Immunoglobulin like
      cl11960
      Location:151 → 222
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      51119778..51136263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438615.1 → XP_047294571.1  sialic acid-binding Ig-like lectin 9 isoform X2

      UniProtKB/Swiss-Prot
      Q6GTU4, Q9BYI9, Q9Y336

    2. XM_047438616.1 → XP_047294572.1  sialic acid-binding Ig-like lectin 9 isoform X2

      UniProtKB/Swiss-Prot
      Q6GTU4, Q9BYI9, Q9Y336

    3. XM_011526732.4 → XP_011525034.1  sialic acid-binding Ig-like lectin 9 isoform X1

      Conserved Domains (3) summary
      cd05712
      Location:23 → 140
      Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
      smart00410
      Location:258 → 336
      IG_like; Immunoglobulin like
      cl11960
      Location:151 → 222
      Ig; Immunoglobulin domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      54211244..54230912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320566.1 → XP_054176541.1  sialic acid-binding Ig-like lectin 9 isoform X2

      UniProtKB/Swiss-Prot
      Q6GTU4, Q9BYI9, Q9Y336

    2. XM_054320565.1 → XP_054176540.1  sialic acid-binding Ig-like lectin 9 isoform X1

    3. XM_054320567.1 → XP_054176542.1  sialic acid-binding Ig-like lectin 9 isoform X4

    4. XM_054320564.1 → XP_054176539.1  sialic acid-binding Ig-like lectin 9 isoform X3

    5. XM_054320568.1 → XP_054176543.1  sialic acid-binding Ig-like lectin 9 isoform X5

    6. XM_054320569.1 → XP_054176544.1  sialic acid-binding Ig-like lectin 9 isoform X6

    7. XM_054320570.1 → XP_054176545.1  sialic acid-binding Ig-like lectin 9 isoform X7

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y336.2 GenPept UniProtKB/Swiss-Prot:Q9Y336

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