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    IL13RA2 interleukin 13 receptor subunit alpha 2 [ Homo sapiens (human) ]

    Gene ID: 3598, updated on 27-Dec-2024

    Summary

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    Official Symbol
    IL13RA2provided by HGNC
    Official Full Name
    interleukin 13 receptor subunit alpha 2provided by HGNC
    Primary source
    HGNC:HGNC:5975
    See related
    Ensembl:ENSG00000123496 MIM:300130; AllianceGenome:HGNC:5975
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT19; IL-13R; IL13BP; CD213A2
    Summary
    The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in testis (RPKM 16.6), appendix (RPKM 2.7) and 6 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IL13RA2 in Genome Data Viewer
    Location:
    Xq23
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (115003982..115017616, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (113412686..113451239, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (114238545..114252179, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine receptor 2C Neighboring gene uncharacterized LOC105373313 Neighboring gene heat shock protein family A (Hsp70) member 8 pseudogene 7 Neighboring gene microRNA 448 Neighboring gene MED14-independent group 3 enhancer GRCh37_chrX:114140926-114142125 Neighboring gene RNA, U6 small nuclear 648, pseudogene Neighboring gene zinc finger protein 670 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. cDNA clone, prokaryotic expression and purification of human interleukin-13 receptor [alpha]2 chain. Yu W, et al. Cancer Immunol Immunother, 2009 Mar. PMID 18677476, Free PMC Article
    2. IL-13 receptor α2 stimulates human glioma cell growth and metastasis through the Src/PI3K/Akt/mTOR signaling pathway. Tu M, et al. Tumour Biol, 2016 Nov. PMID 27623944
    3. Interleukin-13 receptor α2 is associated with poor prognosis in patients with gastric cancer after gastrectomy. Lin C, et al. Oncotarget, 2016 Aug 2. PMID 27351230, Free PMC Article
    4. A novel single-chain antibody redirects adenovirus to IL13Rα2-expressing brain tumors. Kim JW, et al. Sci Rep, 2015 Dec 14. PMID 26656559, Free PMC Article
    5. Interleukin-13 receptor alpha 2-targeted glioblastoma immunotherapy. Sengupta S, et al. Biomed Res Int, 2014. PMID 25247196, Free PMC Article

    See all (111) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IL-13RA2 downregulation in fibroblasts promotes keloid fibrosis via JAK/STAT6 activation.
      Title: IL-13RA2 downregulation in fibroblasts promotes keloid fibrosis via JAK/STAT6 activation.
    2. Identification of the alpha2 chain of interleukin-13 receptor as a potential biomarker for predicting castration resistance of prostate cancer using patient-derived xenograft models.
      Title: Identification of the α2 chain of interleukin-13 receptor as a potential biomarker for predicting castration resistance of prostate cancer using patient-derived xenograft models.
    3. IL13Ralpha2 Promotes Proliferation and Outgrowth of Breast Cancer Brain Metastases.
      Title: IL13Rα2 Promotes Proliferation and Outgrowth of Breast Cancer Brain Metastases.
    4. Silencing of IL13RA2 promotes partial epithelial-mesenchymal transition in hepatocellular carcinoma via ERK signaling pathway activation.
      Title: Silencing of IL13RA2 promotes partial epithelial-mesenchymal transition in hepatocellular carcinoma via ERK signaling pathway activation.
    5. IL13Ralpha2 and EGFRtargeted pseudomonas exotoxin potentiates the TRAILmediated death of GBM cells.
      Title: IL13Rα2‑ and EGFR‑targeted pseudomonas exotoxin potentiates the TRAIL‑mediated death of GBM cells.
    6. Identification of serum interleukin-13 and interleukin-13 receptor subunit expressions: Rheumatoid arthritis-associated interstitial lung disease.
      Title: Identification of serum interleukin-13 and interleukin-13 receptor subunit expressions: Rheumatoid arthritis-associated interstitial lung disease.
    7. M2a Macrophage-Secreted CHI3L1 Promotes Extracellular Matrix Metabolic Imbalances via Activation of IL-13Ralpha2/MAPK Pathway in Rat Intervertebral Disc Degeneration.
      Title: M2a Macrophage-Secreted CHI3L1 Promotes Extracellular Matrix Metabolic Imbalances via Activation of IL-13Rα2/MAPK Pathway in Rat Intervertebral Disc Degeneration.
    8. IL-13Ralpha2 gene expression is a biomarker of adverse outcome in patients with adrenocortical carcinoma.
      Title: IL-13Rα2 gene expression is a biomarker of adverse outcome in patients with adrenocortical carcinoma.
    9. Involvement of IL-4, IL-13 and Their Receptors in Pancreatic Cancer.
      Title: Involvement of IL-4, IL-13 and Their Receptors in Pancreatic Cancer.
    10. Transcriptional regulation of the IL-13Ralpha2 gene in human lung fibroblasts.
      Title: Transcriptional regulation of the IL-13Rα2 gene in human lung fibroblasts.
    Submit: New GeneRIF Correction See all GeneRIFs (84)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytokine receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytokine receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immunoglobulin mediated immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in interleukin-13-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of immunoglobulin production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of mast cell degranulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular space TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-13 receptor subunit alpha-2
    Names
    IL-13 receptor subunit alpha-2
    IL-13R subunit alpha-2
    IL-13R-alpha-2
    IL-13RA2
    cancer/testis antigen 19
    interleukin 13 binding protein
    interleukin 13 receptor alpha 2 chain
    interleukin 13 receptor, alpha 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012514.1 RefSeqGene

      Range
      5029..18663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000640.3 → NP_000631.1  interleukin-13 receptor subunit alpha-2 precursor

      See identical proteins and their annotated locations for NP_000631.1

      Status: REVIEWED

      Source sequence(s)
      Y08768
      Consensus CDS
      CCDS14565.1
      UniProtKB/Swiss-Prot
      A8K7E2, O00667, Q14627
      Related
      ENSP00000243213.1, ENST00000243213.2
      Conserved Domains (1) summary
      pfam09240
      Location:142 → 235
      IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      115003982..115017616 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      113412686..113451239 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327032.1 → XP_054183007.1  interleukin-13 receptor subunit alpha-2 isoform X1

      UniProtKB/Swiss-Prot
      A8K7E2, O00667, Q14627

    2. XM_054327033.1 → XP_054183008.1  interleukin-13 receptor subunit alpha-2 isoform X1

      UniProtKB/Swiss-Prot
      A8K7E2, O00667, Q14627
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14627.1 GenPept UniProtKB/Swiss-Prot:Q14627

    Gene LinkOut

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