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    RECK reversion inducing cysteine rich protein with kazal motifs [ Homo sapiens (human) ]

    Gene ID: 8434, updated on 10-Dec-2024

    Summary

    Official Symbol
    RECKprovided by HGNC
    Official Full Name
    reversion inducing cysteine rich protein with kazal motifsprovided by HGNC
    Primary source
    HGNC:HGNC:11345
    See related
    Ensembl:ENSG00000122707 MIM:605227; AllianceGenome:HGNC:11345
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ST15
    Summary
    The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
    Expression
    Ubiquitous expression in gall bladder (RPKM 6.7), endometrium (RPKM 6.4) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RECK in Genome Data Viewer
    Location:
    9p13.3
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (36036913..36124455)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (36058906..36146459)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (36036910..36124452)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily S member 1 pseudogene Neighboring gene olfactory receptor family 2 subfamily AM member 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19885 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19886 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28344 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36102296-36102796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19888 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19889 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28345 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28346 Neighboring gene GLI pathogenesis related 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:36161748-36162328 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:36162329-36162909 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28347 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:36166491-36166991 Neighboring gene calicin

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (13 hits/1261 screens)

    EBI GWAS Catalog

    Description
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables Wnt-protein binding  
    enables coreceptor activity  
    enables endopeptidase inhibitor activity  
    enables endopeptidase inhibitor activity PubMed 
    enables metalloendopeptidase inhibitor activity PubMed 
    enables protein binding PubMed 
    enables serine-type endopeptidase inhibitor activity  
    Process Evidence Code Pubs
    involved_in blood vessel maturation  
    involved_in canonical Wnt signaling pathway  
    involved_in embryo implantation  
    involved_in embryonic forelimb morphogenesis  
    involved_in extracellular matrix organization  
    involved_in negative regulation of cell migration PubMed 
    involved_in negative regulation of metalloendopeptidase activity PubMed 
    involved_in negative regulation of metalloendopeptidase activity  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in regulation of angiogenesis  
    involved_in regulation of canonical Wnt signaling pathway  
    involved_in regulation of establishment of blood-brain barrier  
    involved_in regulation of extracellular matrix organization PubMed 
    involved_in sprouting angiogenesis  
    Component Evidence Code Pubs
    part_of Wnt signalosome  
    located_in extracellular region  
    located_in membrane PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in side of membrane  

    General protein information

    Preferred Names
    reversion-inducing cysteine-rich protein with Kazal motifs
    Names
    membrane-anchored glycoprotein (metastasis and invasion)
    suppression of tumorigenicity 15 (reversion-inducing-cysteine-rich protein with kazal motifs)
    suppression of tumorigenicity 5 (reversion-inducing-cysteine-rich protein with kazal motifs)
    suppressor of tumorigenicity 15 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316345.2 → NP_001303274.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains two alternate exons in the 5' end compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK292653, BC050306
      UniProtKB/TrEMBL
      A8K9D8
      Conserved Domains (2) summary
      pfam14828
      Location:674 → 739
      Amnionless
      cl28910
      Location:505 → 571
      MFS; Major Facilitator Superfamily
    2. NM_001316346.2 → NP_001303275.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate 3'-most exon in place of the last 13 exons compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK292653, AL138834, BC060806, BX393623, CA431378
      UniProtKB/TrEMBL
      Q6P9E2
    3. NM_001316347.2 → NP_001303276.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate 3'-most exon in place of the last 13 exons compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK292653, BC060806, CA431378, JQ756320
      UniProtKB/TrEMBL
      Q6P9E2
    4. NM_001316348.2 → NP_001303277.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate 3'-most exon in place of the last 13 exons compared to variant 1. The resulting isoform (5) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK292653, BC060806, CA431378
      UniProtKB/TrEMBL
      Q6P9E2
      Related
      ENST00000479053.1
    5. NM_021111.3 → NP_066934.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform 1 precursor

      See identical proteins and their annotated locations for NP_066934.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK292653, BC050306, D50406
      Consensus CDS
      CCDS6597.1
      UniProtKB/Swiss-Prot
      B2RNS1, O95980, Q5W0K6, Q8WX37
      UniProtKB/TrEMBL
      A8K9D8
      Related
      ENSP00000367202.3, ENST00000377966.4
      Conserved Domains (2) summary
      pfam03137
      Location:633 → 658
      OATP; Organic Anion Transporter Polypeptide (OATP) family
      pfam14828
      Location:802 → 886
      Amnionless; Amnionless

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      36036913..36124455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017015207.2 → XP_016870696.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform X1

      UniProtKB/TrEMBL
      A8K9D8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      36058906..36146459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363985.1 → XP_054219960.1  reversion-inducing cysteine-rich protein with Kazal motifs isoform X1

      UniProtKB/TrEMBL
      A8K9D8
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