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    Cyp4ae1 Cytochrome P450 4ae1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31193, updated on 12-Dec-2024

    Summary

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    Official Symbol
    Cyp4ae1provided by FlyBase
    Official Full Name
    Cytochrome P450 4ae1provided by FlyBase
    Primary source
    FLYBASE:FBgn0015036
    Locus tag
    Dmel_CG10755
    See related
    AllianceGenome:FB:FBgn0015036
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4ae1; anon-2Ea; CG10755; Cyp4e4; CYP4E4; Cypae1; Dmel\CG10755; EG:152A3.6; I; P-450; P450; TcD20
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head; embryonic head; embryonic/larval epidermis; embryonic/larval tracheal section; and organism. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp4ae1 in Genome Data Viewer
    Location:
    2E1-2E1; 1-0.8 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2179007..2180998)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2073040..2075031)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45479 Neighboring gene Cytochrome P450 4d14 Neighboring gene antisense RNA:CR44690 Neighboring gene Cytochrome P450 4d2 Neighboring gene prune Neighboring gene Nonsense-mediated mRNA 3 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of the prune locus of Drosophila melanogaster. Teng DH, et al. Genetics, 1991 Jun. PMID 1649071, Free PMC Article
    2. A product of the prune locus of Drosophila is similar to mammalian GTPase-activating protein. Teng DH, et al. Nature, 1991 Oct 3. PMID 1654526
    3. Genetic and molecular analysis of wings apart-like (wapl), a gene controlling heterochromatin organization in Drosophila melanogaster. Vernì F, et al. Genetics, 2000 Apr. PMID 10747063, Free PMC Article
    4. Molecular analysis of a cytochrome P450 gene of family 4 on the Drosophila X chromosome. Gandhi R, et al. DNA Cell Biol, 1992 Jun. PMID 1605861
    5. Cytochrome P450 gene clusters in Drosophila melanogaster. Dunkov BC, et al. Mol Gen Genet, 1996 Jun 12. PMID 8676871

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 4ae1
    Names
    CG10755-PA
    Cyp4ae1-PA
    cytochrome P450-4ae1
    transcription unit I
    NP_525044.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2179007..2180998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080305.4 → NP_525044.1  cytochrome P450 4ae1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525044.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46054, Q24129
      Related
      FBpp0070372
      Conserved Domains (1) summary
      pfam00067
      Location:35 → 486
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O46054.1 O46054

    Gene LinkOut

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