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    S1P Site-1 protease [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40399, updated on 9-Dec-2024

    Summary

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    Official Symbol
    S1Pprovided by FlyBase
    Official Full Name
    Site-1 proteaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037105
    Locus tag
    Dmel_CG7169
    See related
    AllianceGenome:FB:FBgn0037105
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7169; Dmel\CG7169; dS1P; SKI-1/S1P
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in spondyloepiphyseal dysplasia Kondo-Fu type. Orthologous to human MBTPS1 (membrane bound transcription factor peptidase, site 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See S1P in Genome Data Viewer
    Location:
    78E1-78E1; 3-47 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21613797..21617376, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21606897..21610476, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43939 Neighboring gene hairpin RNA:CR46340 Neighboring gene Transcription factor AP-2 Neighboring gene long non-coding RNA:CR43940 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mechanism of Folding and Activation of Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P). da Palma JR, et al. J Biol Chem, 2016 Jan 29. PMID 26645686, Free PMC Article
    2. The SREBP pathway--insights from Insigs and insects. Rawson RB. Nat Rev Mol Cell Biol, 2003 Aug. PMID 12923525
    3. Activation of sterol regulatory element-binding protein by the caspase Drice in Drosophila larvae. Amarneh B, et al. J Biol Chem, 2009 Apr 10. PMID 19224859, Free PMC Article
    4. The SREBP pathway in Drosophila: regulation by palmitate, not sterols. Seegmiller AC, et al. Dev Cell, 2002 Feb. PMID 11832248
    5. Transcriptional Feedback Links Lipid Synthesis to Synaptic Vesicle Pools in Drosophila Photoreceptors. Tsai JW, et al. Neuron, 2019 Feb 20. PMID 30737130, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Site-1 protease
    Names
    CG7169-PA
    S1P-PA
    subtilisin kexin isozyme-1/site-1 protease
    NP_649337.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21613797..21617376 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141080.3 → NP_649337.2  Site-1 protease [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649337.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8N0B7, Q9VP10
      Related
      FBpp0078120
      Conserved Domains (3) summary
      cd07479
      Location:154 → 407
      Peptidases_S8_SKI-1_like; Peptidase S8 family domain in SKI-1-like proteins
      pfam00082
      Location:160 → 416
      Peptidase_S8; Subtilase family
      pfam14258
      Location:610 → 673
      DUF4350; Domain of unknown function (DUF4350)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VP10 Q9VP10

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