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    Cog1 Component of oligomeric golgi complex 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41479, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cog1provided by FlyBase
    Official Full Name
    Component of oligomeric golgi complex 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0037998
    Locus tag
    Dmel_CG4848
    See related
    AllianceGenome:FB:FBgn0037998
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4848; cog1; COG1; Dmel\CG4848
    Summary
    Predicted to be involved in Golgi organization and intra-Golgi vesicle-mediated transport. Part of Golgi transport complex. Is expressed in several structures, including adult head; gland; gut section; salivary gland body primordium; and spermatozoon. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIg. Orthologous to human COG1 (component of oligomeric golgi complex 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cog1 in Genome Data Viewer
    Location:
    87B2-87B2; 3-52 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12213792..12219686, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8039514..8045408, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene transfer RNA:Threonine-TGT 1-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46012 Neighboring gene uncharacterized protein Neighboring gene Radial spoke binding protein 15 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors. Comstra HS, et al. Elife, 2017 Mar 29. PMID 28355134, Free PMC Article
    2. Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial Content. Hartwig C, et al. J Neurosci, 2021 Jan 13. PMID 33208468, Free PMC Article
    3. Role of the conserved oligomeric Golgi (COG) complex in protein glycosylation. Smith RD, et al. Carbohydr Res, 2008 Aug 11. PMID 18353293, Free PMC Article
    4. Molecular physiology of copper in Drosophila melanogaster. Burke R. Curr Opin Insect Sci, 2022 Jun. PMID 35247643
    5. The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity. Fox RM, et al. J Cell Biol, 2010 Nov 1. PMID 21041443, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of Golgi transport complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Golgi transport complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    component of oligomeric golgi complex 1
    Names
    CG4848-PA
    CG4848-PB
    CG4848-PC
    Cog1-PA
    Cog1-PB
    Cog1-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12213792..12219686 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275568.1 → NP_001262497.1  component of oligomeric golgi complex 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262497.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VGC3
      UniProtKB/TrEMBL
      A0A0B4KGW7
      Conserved Domains (1) summary
      pfam08700
      Location:4 → 84
      Vps51; Vps51/Vps67

    2. NM_141905.3 → NP_650162.1  component of oligomeric golgi complex 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650162.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VGC3
      UniProtKB/TrEMBL
      A0A0B4KGW7
      Related
      FBpp0082093
      Conserved Domains (1) summary
      pfam08700
      Location:4 → 84
      Vps51; Vps51/Vps67

    3. NM_001275567.1 → NP_001262496.1  component of oligomeric golgi complex 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262496.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KH76
      Conserved Domains (1) summary
      pfam08700
      Location:4 → 84
      Vps51; Vps51/Vps67
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGW7 A0A0B4KGW7
    A0A0B4KH76 A0A0B4KH76
    Q9VGC3.1 Q9VGC3

    Gene LinkOut

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