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    mst misato [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33119, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mstprovided by FlyBase
    Official Full Name
    misatoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020272
    Locus tag
    Dmel_CG1424
    See related
    AllianceGenome:FB:FBgn0020272
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1424; Dmel\CG1424; l(1)19Fg; l(1)LB14; l(1)LB20; LB-20; LB20; lLB14; MST1/2
    Summary
    Involved in mitotic spindle assembly. Located in cytoplasm. Is expressed in adult brain; brain; embryonic/larval fat body; imaginal disc; and ovary. Used to study myotonia congenita. Orthologous to human MSTO1 (misato mitochondrial distribution and morphology regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mst in Genome Data Viewer
    Location:
    20A1-20A1; 1-66 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21388977..21391533)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21260004..21262560)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45611 Neighboring gene sluggish A Neighboring gene ncRNA Neighboring gene DEAD-box helicase 56 Neighboring gene long non-coding RNA:CR45500 Neighboring gene la costa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Preliminary characterisation of DML1, an essential Saccharomyces cerevisiae gene related to misato of Drosophila melanogaster. Gurvitz A, et al. FEMS Yeast Res, 2002 May. PMID 12702300
    2. An essential cell division gene of Drosophila, absent from Saccharomyces, encodes an unusual protein with tubulin-like and myosin-like peptide motifs. Miklos GL, et al. Proc Natl Acad Sci U S A, 1997 May 13. PMID 9144213, Free PMC Article
    3. Genomic imprinting in Drosophila has properties of both mammalian and insect imprinting. Anaka M, et al. Dev Genes Evol, 2009 Feb. PMID 19031081
    4. Age-dependent expression profiles of two adaptogenic systems and thermotolerance in Drosophila melanogaster. Shilova V, et al. Cell Stress Chaperones, 2020 Mar. PMID 32040825, Free PMC Article
    5. Phenotypic analysis of misato function reveals roles of noncentrosomal microtubules in Drosophila spindle formation. Mottier-Pavie V, et al. J Cell Sci, 2011 Mar 1. PMID 21285248

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Misato Controls Mitotic Microtubule Generation by Stabilizing the TCP-1 Tubulin Chaperone Complex.
      Title: Misato Controls Mitotic Microtubule Generation by Stabilizing the TCP-1 Tubulin Chaperone Complex [corrected].
    2. sData how that mutations in the Drosophila misato gene inhibit kinetochore-driven microtubule growth, lead to the formation of monopolar spindles and cause larval lethality.
      Title: Phenotypic analysis of misato function reveals roles of noncentrosomal microtubules in Drosophila spindle formation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    misato
    Names
    CG1424-PA
    CG1424-PB
    MST1/2
    lethal(1)19Fg
    mst-PA
    mst-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      21388977..21391533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298589.1 → NP_001285518.1  misato, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285518.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01939, Q8MSB2
      UniProtKB/TrEMBL
      X2JG23
      Conserved Domains (1) summary
      cd06060
      Location:5 → 570
      misato; Misato segment II tubulin-like domain

    2. NM_078711.5 → NP_523435.1  misato, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523435.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O01939, Q8MSB2
      UniProtKB/TrEMBL
      X2JG23
      Related
      FBpp0076907
      Conserved Domains (1) summary
      cd06060
      Location:5 → 570
      misato; Misato segment II tubulin-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O01939.1 O01939
    X2JG23 X2JG23

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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