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    ReepA Receptor expression enhancing protein A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37643, updated on 17-Dec-2024

    Summary

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    Official Symbol
    ReepAprovided by FlyBase
    Official Full Name
    Receptor expression enhancing protein Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261564
    Locus tag
    Dmel_CG42678
    See related
    AllianceGenome:FB:FBgn0261564
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.113; BcDNA:LD42159; BcDNA:RE29641; CG30190; CG30193; CG42678; CG9848; D-reep1; Dmel\CG42678; reep1; Reep1; REEP1; REEPA
    Old locus tag
    Dmel_CG30190; Dmel_CG30193
    Summary
    Predicted to enable microtubule binding activity. Involved in endoplasmic reticulum organization and response to endoplasmic reticulum stress. Located in endoplasmic reticulum and presynapse. Is expressed in several structures, including adult brain cell body rind; anterior-posterior subdivision of organism; central brain primordium; ganglia; and mesoderm. Used to study hereditary spastic paraplegia 31. Human ortholog(s) of this gene implicated in autosomal dominant distal hereditary motor neuronopathy 12; autosomal recessive distal hereditary motor neuronopathy 6; hereditary spastic paraplegia 31; and hereditary spastic paraplegia 72A. Orthologous to several human genes including REEP4 (receptor accessory protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ReepA in Genome Data Viewer
    Location:
    59B6-59B6; 2-101 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22925107..22932044)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18812630..18819567)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Nucleoporin 214kD Neighboring gene uncharacterized protein Neighboring gene CCHC-type zinc finger nucleic acid binding protein Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor-like Holozoa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hereditary Spastic Paraplegia and Future Therapeutic Directions: Beneficial Effects of Small Compounds Acting on Cellular Stress. Gumeni S, et al. Front Neurosci, 2021. PMID 34025345, Free PMC Article
    2. Endoplasmic Reticulum Lumenal Indicators in Drosophila Reveal Effects of HSP-Related Mutations on Endoplasmic Reticulum Calcium Dynamics. Oliva MK, et al. Front Neurosci, 2020. PMID 32903680, Free PMC Article
    3. Naringenin Ameliorates Drosophila ReepA Hereditary Spastic Paraplegia-Linked Phenotypes. Napoli B, et al. Front Neurosci, 2019. PMID 31803000, Free PMC Article
    4. A Screen for Synaptic Growth Mutants Reveals Mechanisms That Stabilize Synaptic Strength. Goel P, et al. J Neurosci, 2019 May 22. PMID 30902873, Free PMC Article
    5. Non-Rodent Genetic Animal Models for Studying Tauopathy: Review of Drosophila, Zebrafish, and C. elegans Models. Giong HK, et al. Int J Mol Sci, 2021 Aug 6. PMID 34445171, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila REEP1 promotes neuronal stress resistance and prevents the formation of Tau aggregates.
      Title: Functional screening in Drosophila reveals the conserved role of REEP1 in promoting stress resistance and preventing the formation of Tau aggregates.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum tubular network organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum tubular network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    receptor expression enhancing protein A
    Names
    CG42678-PD
    CG42678-PE
    CG42678-PG
    CG42678-PH
    CG42678-PI
    CG42678-PJ
    CG42678-PK
    CG42678-PL
    CG42678-PO
    CG42678-PP
    CG42678-PQ
    CG42678-PR
    CG42678-PS
    REEP1 homolog
    REEP1 ortholog
    ReepA-PD
    ReepA-PE
    ReepA-PG
    ReepA-PH
    ReepA-PI
    ReepA-PJ
    ReepA-PK
    ReepA-PL
    ReepA-PO
    ReepA-PP
    ReepA-PQ
    ReepA-PR
    ReepA-PS
    receptor expression enhancing protein 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22925107..22932044
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103955.3 → NP_001097425.1  receptor expression enhancing protein A, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097425.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JRH2
      Conserved Domains (1) summary
      pfam03134
      Location:7 → 94
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    2. NM_001202060.2 → NP_001188989.1  receptor expression enhancing protein A, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188989.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JD87
      Conserved Domains (1) summary
      pfam03134
      Location:7 → 94
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    3. NM_001202058.2 → NP_001188987.1  receptor expression enhancing protein A, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188987.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JD44
      Conserved Domains (1) summary
      pfam03134
      Location:7 → 94
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    4. NM_001202061.2 → NP_001188990.2  receptor expression enhancing protein A, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188990.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JCV3
      Conserved Domains (1) summary
      pfam03134
      Location:7 → 94
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    5. NM_001299822.1 → NP_001286751.1  receptor expression enhancing protein A, isoform S [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286751.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LG73
      Conserved Domains (1) summary
      pfam03134
      Location:19 → 95
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    6. NM_166574.3 → NP_726269.1  receptor expression enhancing protein A, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726269.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JRH2
      Conserved Domains (1) summary
      pfam03134
      Location:7 → 94
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    7. NM_001202059.2 → NP_001188988.1  receptor expression enhancing protein A, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188988.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JCU3
      Conserved Domains (1) summary
      pfam03134
      Location:158 → 241
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    8. NM_001299820.1 → NP_001286749.1  receptor expression enhancing protein A, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286749.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LH91
      Conserved Domains (1) summary
      pfam03134
      Location:158 → 241
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    9. NM_001299821.1 → NP_001286750.1  receptor expression enhancing protein A, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286750.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LG90
      Conserved Domains (1) summary
      pfam03134
      Location:158 → 241
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    10. NM_166576.3 → NP_726271.1  receptor expression enhancing protein A, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726271.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SX60
      Conserved Domains (1) summary
      pfam03134
      Location:158 → 241
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    11. NM_001274215.1 → NP_001261144.1  receptor expression enhancing protein A, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261144.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEX8
      Conserved Domains (1) summary
      pfam03134
      Location:162 → 241
      TB2_DP1_HVA22; TB2/DP1, HVA22 family

    12. NM_001103956.3 → NP_001097426.1  receptor expression enhancing protein A, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097426.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYN0

    13. NM_137893.4 → NP_611737.2  receptor expression enhancing protein A, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611737.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W1X3
      Related
      FBpp0291912
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JCU3 A0A0B4JCU3
    A0A0B4JCV3 A0A0B4JCV3
    A0A0B4JD44 A0A0B4JD44
    A0A0B4JD87 A0A0B4JD87
    A0A0B4KEX8 A0A0B4KEX8
    A0A0B4LG73 A0A0B4LG73
    A0A0B4LG90 A0A0B4LG90
    A0A0B4LH91 A0A0B4LH91
    A8DYN0 A8DYN0
    Q7JRH2 Q7JRH2
    Q8SX60 Q8SX60
    Q8T0K4 Q8T0K4
    Q9W1X3 Q9W1X3

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