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    Cpsf160 Cleavage and polyadenylation specificity factor 160 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44250, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cpsf160provided by FlyBase
    Official Full Name
    Cleavage and polyadenylation specificity factor 160provided by FlyBase
    Primary source
    FLYBASE:FBgn0024698
    Locus tag
    Dmel_CG10110
    See related
    AllianceGenome:FB:FBgn0024698
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.217; CG10110; cpsf; Cpsf; CPSF; CPSF-160; CPSF160; dCPSF-160; Dmel\CG10110
    Summary
    Enables myosin binding activity. Predicted to be involved in mRNA 3'-end processing. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Predicted to be active in nucleus. Is expressed in adult head. Human ortholog(s) of this gene implicated in myopia. Orthologous to human CPSF1 (cleavage and polyadenylation specific factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cpsf160 in Genome Data Viewer
    Location:
    51A4-51A4; 2-71 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14497347..14503488, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10384852..10390993, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44462 Neighboring gene Proline-rich Akt substrate 40 kDa Neighboring gene Additional sex combs Neighboring gene Cuticular protein 51A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a Drosophila homologue of the 160-kDa subunit of the cleavage and polyadenylation specificity factor CPSF. Salinas CA, et al. Mol Gen Genet, 1998 Apr. PMID 9604891
    2. ELAV inhibits 3'-end processing to promote neural splicing of ewg pre-mRNA. Soller M, et al. Genes Dev, 2003 Oct 15. PMID 14522950, Free PMC Article
    3. The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes. Sinclair DA, et al. Development, 1998 Apr. PMID 9477319
    4. The Additional sex combs gene of Drosophila is required for activation and repression of homeotic loci, and interacts specifically with Polycomb and super sex combs. Milne TA, et al. Mol Gen Genet, 1999 Jun. PMID 10394912
    5. Loss of Histone Locus Bodies in the Mature Hemocytes of Larval Lymph Gland Result in Hyperplasia of the Tissue in mxc Mutants of Drosophila. Kurihara M, et al. Int J Mol Sci, 2020 Feb 26. PMID 32111032, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c14498549-14497444 mobile_element_type = transposon:1360{}829

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables myosin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA 3'-end processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cleavage and polyadenylation specificity factor 160
    Names
    CG10110-PA
    CG10110-PB
    Cpsf160-PA
    Cpsf160-PB
    cleavage and polyadenylation specificity factor
    drosophila cleavage and polyadenylation stimulation factor-160

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14497347..14503488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206111.3 → NP_995833.1  cleavage and polyadenylation specificity factor 160, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995833.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KR84, Q960R9, Q9GV83, Q9GV84, Q9GV85, Q9V726
      Conserved Domains (3) summary
      COG5161
      Location:1 → 1453
      SFT1; Pre-mRNA cleavage and polyadenylation specificity factor [RNA processing and modification]
      pfam03178
      Location:1086 → 1419
      CPSF_A; CPSF A subunit region
      pfam10433
      Location:94 → 674
      MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term

    2. NM_166056.3 → NP_725397.1  cleavage and polyadenylation specificity factor 160, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725397.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V726
      Related
      FBpp0088317
      Conserved Domains (3) summary
      COG5161
      Location:1 → 1418
      SFT1; Pre-mRNA cleavage and polyadenylation specificity factor [RNA processing and modification]
      pfam03178
      Location:1051 → 1384
      CPSF_A; CPSF A subunit region
      pfam10433
      Location:94 → 639
      MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V726.1 Q9V726

    Gene LinkOut

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