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    • Showing Current items.

    klhl10 kelch like family member 10 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3354863, updated on 9-Dec-2024

    Summary

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    Official Symbol
    klhl10provided by FlyBase
    Official Full Name
    kelch like family member 10provided by FlyBase
    Primary source
    FLYBASE:FBgn0040038
    Locus tag
    Dmel_CG12423
    See related
    AllianceGenome:FB:FBgn0040038
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.152; CG12423; Dmel\CG12423; Klhl10
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in protein ubiquitination and sperm individualization. Part of Cul3-RING ubiquitin ligase complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in spermatogenic failure 11. Orthologous to human KLHL10 (kelch like family member 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See klhl10 in Genome Data Viewer
    Location:
    chromosome: Unknown
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) Unplaced Scaffold NW_007931083.1 (53442..85529)

    NW_007931083.1Genomic Context describing neighboring genes Neighboring gene Glycoprotein hormone alpha 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_007931083.1 Unplaced Scaffold Reference Release 6 plus ISO1 MT Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gradients of a ubiquitin E3 ligase inhibitor and a caspase inhibitor determine differentiation or death in spermatids. Kaplan Y, et al. Dev Cell, 2010 Jul 20. PMID 20643358
    2. A comparative genomic approach using mouse and fruit fly data to discover genes involved in testis function in hymenopterans with a focus on Nasonia vitripennis. Lécureuil C, et al. BMC Ecol Evol, 2021 May 19. PMID 34011283, Free PMC Article
    3. A Krebs Cycle Component Limits Caspase Activation Rate through Mitochondrial Surface Restriction of CRL Activation. Aram L, et al. Dev Cell, 2016 Apr 4. PMID 27052834
    4. A ubiquitin ligase complex regulates caspase activation during sperm differentiation in Drosophila. Arama E, et al. PLoS Biol, 2007 Oct. PMID 17880263, Free PMC Article
    5. Caspase-dependent non-apoptotic processes in development. Nakajima YI, et al. Cell Death Differ, 2017 Aug. PMID 28524858, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kelch like family member 10
    Names
    CG12423-PA
    CG12423-PB
    klhl10-PA
    klhl10-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NW_007931083.1 Reference assembly

      Range
      53442..85529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001015101.2 → NP_001015101.2  kelch like family member 10, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015101.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q500X7, Q6GKZ1, Q7PLC2
      Conserved Domains (6) summary
      smart00612
      Location:490 → 536
      Kelch; Kelch domain
      PHA03098
      Location:86 → 610
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:432 → 475
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:72 → 186
      BTB; BTB/POZ domain
      pfam01344
      Location:431 → 476
      Kelch_1; Kelch motif
      pfam07707
      Location:195 → 298
      BACK; BTB And C-terminal Kelch

    2. NM_001015100.2 → NP_001015100.2  kelch like family member 10, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015100.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q500X7, Q6GKZ1, Q7PLC2
      Conserved Domains (6) summary
      smart00612
      Location:490 → 536
      Kelch; Kelch domain
      PHA03098
      Location:86 → 610
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:432 → 475
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:72 → 186
      BTB; BTB/POZ domain
      pfam01344
      Location:431 → 476
      Kelch_1; Kelch motif
      pfam07707
      Location:195 → 298
      BACK; BTB And C-terminal Kelch
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6GKZ1 Q6GKZ1

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