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    Dic3 Dicarboxylate carrier 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35763, updated on 17-Dec-2024

    Summary

    Official Symbol
    Dic3provided by FlyBase
    Official Full Name
    Dicarboxylate carrier 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0033248
    Locus tag
    Dmel_CG11196
    See related
    AllianceGenome:FB:FBgn0033248
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11196; Dic3p; Dmel\CG11196
    Summary
    Enables phosphate transmembrane transporter activity; sulfate transmembrane transporter activity; and thiosulfate transmembrane transporter activity. Involved in phosphate ion transmembrane transport; sulfate transmembrane transport; and thiosulfate transport. Located in mitochondrion. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 19. Orthologous to human SLC25A10 (solute carrier family 25 member 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Dic3 in Genome Data Viewer
    Location:
    44A2-44A2; 2-58 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7993798..7994968, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3881303..3882473, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Acetyl-CoA carboxylase Neighboring gene Nucleoporin at 44A Neighboring gene long non-coding RNA:CR44272 Neighboring gene Hairy/E(spl)-related with YRPW motif Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT enables malate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables oxaloacetate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables succinate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sulfate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables thiosulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables thiosulfate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    NOT involved_in malate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in oxaloacetate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphate ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphate ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in succinate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sulfate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sulfate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in thiosulfate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in thiosulfate transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dicarboxylate carrier 3
    Names
    CG11196-PA
    CG11196-PB
    Dic3-PA
    Dic3-PB

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7993798..7994968 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299250.1NP_001286179.1  dicarboxylate carrier 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286179.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LEV4
      Conserved Domains (1) summary
      pfam00153
      Location:1591
      Mito_carr; Mitochondrial carrier protein
    2. NM_136500.3NP_610344.2  dicarboxylate carrier 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610344.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z787, Q8T406
      Related
      FBpp0087946
      Conserved Domains (2) summary
      PTZ00169
      Location:15275
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:200281
      Mito_carr; Mitochondrial carrier protein