U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Fer3 48 related 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41411, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Fer3provided by FlyBase
    Official Full Name
    48 related 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0037937
    Locus tag
    Dmel_CG6913
    See related
    AllianceGenome:FB:FBgn0037937
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD04689; bHLHa32; CG6913; Dmel\CG6913; Dnato3; nato3
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in developmental process; negative regulation of DNA-templated transcription; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in embryonic brain; embryonic procephalic segment; larval ventral nerve cord; presumptive embryonic/larval central nervous system; and ventral nerve cord primordium. Orthologous to human FERD3L (Fer3 like bHLH transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Fer3 in Genome Data Viewer
    Location:
    86E16-86E16; 3-51 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11693410..11694311, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7519132..7520033, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Transcriptional profiling from whole embryos to single neuroblast lineages in Drosophila. Seroka A, et al. Dev Biol, 2022 Sep. PMID 35660371, Free PMC Article
    2. Mining gene expression data for pollutants (dioxin, toluene, formaldehyde) and low dose of gamma-irradiation. Moskalev A, et al. PLoS One, 2014. PMID 24475070, Free PMC Article
    3. N-twist, an evolutionarily conserved bHLH protein expressed in the developing CNS, functions as a transcriptional inhibitor. Verzi MP, et al. Dev Biol, 2002 Sep 1. PMID 12217327
    4. Nato3 is an evolutionarily conserved bHLH transcription factor expressed in the CNS of Drosophila and mouse. Segev E, et al. Mech Dev, 2001 Aug. PMID 11472856
    5. A genomewide survey of basic helix-loop-helix factors in Drosophila. Moore AW, et al. Proc Natl Acad Sci U S A, 2000 Sep 12. PMID 10973473, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification and genomic structure of Nato3 in fly, mouse and man. Nervous system expression detected in fly and mouse.
      Title: Nato3 is an evolutionarily conserved bHLH transcription factor expressed in the CNS of Drosophila and mouse.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in developmental process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    48 related 3
    Names
    CG6913-PA
    Fer3-PA
    N-twist
    nephew of atonal 3
    ntwist

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11693410..11694311 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079598.3 → NP_524322.1  48 related 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524322.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0AQE5, Q9VGJ5
      UniProtKB/TrEMBL
      C0MK08, C0MK09
      Related
      FBpp0081911
      Conserved Domains (1) summary
      pfam00010
      Location:87 → 135
      HLH; Helix-loop-helix DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VGJ5.2 Q9VGJ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools