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    SdhBL Succinate dehydrogenase, subunit B (iron-sulfur)-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32887, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SdhBLprovided by FlyBase
    Official Full Name
    Succinate dehydrogenase, subunit B (iron-sulfur)-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030975
    Locus tag
    Dmel_CG7349
    See related
    AllianceGenome:FB:FBgn0030975
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7349; DHSB; Dmel\CG7349
    Summary
    Predicted to enable succinate dehydrogenase (quinone) activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone. Predicted to be part of respiratory chain complex II (succinate dehydrogenase). Predicted to be active in mitochondrial membrane. Is expressed in adult head; organism; and spermatozoon. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; mitochondrial complex II deficiency; paraganglioma; and pheochromocytoma. Orthologous to human SDHB (succinate dehydrogenase complex iron sulfur subunit B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SdhBL in Genome Data Viewer
    Location:
    17F2-17F2; 1-61 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18894446..18896581)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18788479..18790614)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Fl(2)d-associated complex component Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44708

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Compartment specific mitochondrial dysfunction in Drosophila knock-in model of ALS reversed by altered gene expression of OXPHOS subunits and pro-fission factor Drp1. Nemtsova Y, et al. Mol Cell Neurosci, 2023 Jun. PMID 36868541, Free PMC Article
    2. Sexually Antagonistic Mitonuclear Coevolution in Duplicate Oxidative Phosphorylation Genes. Havird JC, et al. Integr Comp Biol, 2019 Oct 1. PMID 30942855
    3. Iron absorption in Drosophila melanogaster. Mandilaras K, et al. Nutrients, 2013 May 17. PMID 23686013, Free PMC Article
    4. Genes for iron metabolism influence circadian rhythms in Drosophila melanogaster. Mandilaras K, et al. Metallomics, 2012 Aug. PMID 22885802
    5. Metabolic regulation of proteome stability via N-terminal acetylation controls male germline stem cell differentiation and reproduction. François CM, et al. Nat Commun, 2023 Oct 23. PMID 37872135, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinate dehydrogenase (quinone) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, succinate to ubiquinone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in respiratory electron transport chain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex II (succinate dehydrogenase) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    succinate dehydrogenase, subunit B (iron-sulfur)-like
    Names
    CG7349-PA
    CG7349-PC
    SdhBL-PA
    SdhBL-PC
    ferredoxin
    succinate dehydrogenase Iron-sulfur protein
    succinate dehydrogenase [ubiquinone] iron-sulfur protein
    NP_001285420.1
    NP_573340.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18894446..18896581
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298491.1 → NP_001285420.1  succinate dehydrogenase, subunit B (iron-sulfur)-like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285420.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXL9, Q9VWN3
      Conserved Domains (3) summary
      PRK05950
      Location:189 → 417
      sdhB; succinate dehydrogenase iron-sulfur subunit; Reviewed
      pfam13085
      Location:189 → 293
      Fer2_3; 2Fe-2S iron-sulfur cluster binding domain
      pfam13183
      Location:330 → 403
      Fer4_8; 4Fe-4S dicluster domain

    2. NM_133112.2 → NP_573340.1  succinate dehydrogenase, subunit B (iron-sulfur)-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573340.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXL9, Q9VWN3
      Related
      FBpp0074419
      Conserved Domains (3) summary
      PRK05950
      Location:189 → 417
      sdhB; succinate dehydrogenase iron-sulfur subunit; Reviewed
      pfam13085
      Location:189 → 293
      Fer2_3; 2Fe-2S iron-sulfur cluster binding domain
      pfam13183
      Location:330 → 403
      Fer4_8; 4Fe-4S dicluster domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SXL9 Q8SXL9
    Q9VWN3 Q9VWN3

    Gene LinkOut

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