Acox57D-d acyl-Coenzyme A oxidase at 57D distal [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Acox57D-dprovided by FlyBase
Official Full Name: acyl-Coenzyme A oxidase at 57D distalprovided by FlyBase
Primary source: FLYBASE:FBgn0034629
Locus tag: Dmel_CG9709
See related: AllianceGenome:FB:FBgn0034629
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: aco; acox; Acox57Dd; CG9709; D-acox; Dmel\CG9709
Summary: Predicted to enable acyl-CoA oxidase activity; fatty acid binding activity; and flavin adenine dinucleotide binding activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA oxidase. Predicted to be active in peroxisome. Is expressed in adult head; embryonic dorsal epidermis; embryonic small intestine; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in Mitchell syndrome; congenital bile acid synthesis defect 6; and peroxisomal acyl-CoA oxidase deficiency. Orthologous to several human genes including ACOX1 (acyl-CoA oxidase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (21389405..21392439)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (17276910..17279944)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables FAD binding	IEA Inferred from Electronic Annotation more info
enables acyl-CoA oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acyl-CoA oxidase activity	IEA Inferred from Electronic Annotation more info
enables acyl-CoA oxidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
involved_in fatty acid beta-oxidation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in fatty acid beta-oxidation using acyl-CoA oxidase	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info
located_in peroxisome	ISM Inferred from Sequence Model more info	PubMed
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Names: Acox57D-d-PA; Acyl-coenzyme A oxidase; CG9709-PA; acyl co-enzyme A oxidase; acyl-CoA oxidase

NP_523803.1

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The following sections contain reference sequences that belong to a specific genome build. Explain