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    Adgf-A2 Adenosine deaminase-related growth factor A2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 64879, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adgf-A2provided by FlyBase
    Official Full Name
    Adenosine deaminase-related growth factor A2provided by FlyBase
    Primary source
    FLYBASE:FBgn0043025
    Locus tag
    Dmel_CG32178
    See related
    AllianceGenome:FB:FBgn0043025
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ADGF-A2; BcDNA:AT05468; CG32178; Dmel\CG32178; Msi; MSI
    Summary
    Predicted to enable adenosine deaminase activity. Involved in spermatid development. Located in membrane. Is expressed in adult head; spermatid; spermatocyte; spermatozoon; and testis. Human ortholog(s) of this gene implicated in Sneddon syndrome. Orthologous to human ADA2 (adenosine deaminase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Adgf-A2 in Genome Data Viewer
    Location:
    75A1-75A1; 3-45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17754936..17764158, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17748036..17757258, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ccn Neighboring gene uncharacterized protein Neighboring gene Adenosine deaminase-related growth factor B Neighboring gene Adenosine deaminase-related growth factor A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44668 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Male-specific IDGF, a novel gene encoding a membrane-bound extracellular signaling molecule expressed exclusively in testis of Drosophila melanogaster. Matsushita T, et al. J Biol Chem, 2000 Nov 24. PMID 10967093
    2. Genetic analysis of the ADGF multigene family by homologous recombination and gene conversion in Drosophila. Dolezal T, et al. Genetics, 2003 Oct. PMID 14573477, Free PMC Article
    3. Expression of Drosophila adenosine deaminase in immune cells during inflammatory response. Novakova M, et al. PLoS One, 2011 Mar 11. PMID 21412432, Free PMC Article
    4. Adenosine deaminase-related growth factors stimulate cell proliferation in Drosophila by depleting extracellular adenosine. Zurovec M, et al. Proc Natl Acad Sci U S A, 2002 Apr 2. PMID 11904370, Free PMC Article
    5. Increased extracellular adenosine in Drosophila that are deficient in adenosine deaminase activates a release of energy stores leading to wasting and death. Zuberova M, et al. Dis Model Mech, 2010 Nov-Dec. PMID 20940317

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenosine deaminase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenosine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenosine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenosine catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in inosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatid development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adenosine deaminase-related growth factor A2
    Names
    Adgf-A2-PA
    Adgf-A2-PB
    Adgf-A2-PC
    CG32178-PA
    CG32178-PB
    CG32178-PC
    Male-specific insect derived growth factor
    male-specific IDGF
    male-specific-imaginal-disc-growth-factor
    NP_001036612.1
    NP_001036613.1
    NP_525020.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17754936..17764158 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043148.2 → NP_001036613.1  adenosine deaminase-related growth factor A2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036613.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8D8, Q8IHF6, Q9GRE6
      Conserved Domains (3) summary
      cd01321
      Location:116 → 529
      ADGF; Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors with sequence similarty to adenosine deaminase.
      TIGR01431
      Location:64 → 537
      adm_rel; adenosine deaminase-related growth factor
      pfam08451
      Location:33 → 133
      A_deaminase_N; Adenosine/AMP deaminase N-terminal

    2. NM_001043147.2 → NP_001036612.1  adenosine deaminase-related growth factor A2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036612.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8D8, Q8IHF6, Q9GRE6
      Conserved Domains (3) summary
      cd01321
      Location:116 → 529
      ADGF; Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors with sequence similarty to adenosine deaminase.
      TIGR01431
      Location:64 → 537
      adm_rel; adenosine deaminase-related growth factor
      pfam08451
      Location:33 → 133
      A_deaminase_N; Adenosine/AMP deaminase N-terminal

    3. NM_080281.3 → NP_525020.2  adenosine deaminase-related growth factor A2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525020.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IHF6, Q8IQR3, Q9GRE6
      Related
      FBpp0074956
      Conserved Domains (3) summary
      cd01321
      Location:135 → 548
      ADGF; Adenosine deaminase-related growth factors (ADGF), a novel family of secreted growth-factors with sequence similarty to adenosine deaminase.
      TIGR01431
      Location:83 → 556
      adm_rel; adenosine deaminase-related growth factor
      pfam08451
      Location:52 → 152
      A_deaminase_N; Adenosine/AMP deaminase N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0E8D8 Q0E8D8
    Q8IHF6 Q8IHF6
    Q8IQR3 Q8IQR3
    Q9GRE6 Q9GRE6

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