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    Cdc45 Cell division cycle 45 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31052, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdc45provided by FlyBase
    Official Full Name
    Cell division cycle 45provided by FlyBase
    Primary source
    FLYBASE:FBgn0026143
    Locus tag
    Dmel_CG3658
    See related
    AllianceGenome:FB:FBgn0026143
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-1Ec; cdc45; CDC45; CDC45L; CG3658; D; dCDC45; dCDC45L; DmCdc45; Dmel\CG3658; EG:BACR7A4.11
    Summary
    Enables chromatin binding activity. Involved in DNA amplification; DNA replication; and chromosome condensation. Located in cytoplasm and nucleus. Part of CMG complex. Is expressed in egg chamber. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 7. Orthologous to human CDC45 (cell division cycle 45). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cdc45 in Genome Data Viewer
    Location:
    1E1-1E1; 1-0.1 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1028291..1030556, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (922324..924589, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene suppressor of white-apricot Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ribonuclease P/MRP subunit p21 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High abundance of CDC45 inhibits cell proliferation through elevation of HSPA6. Fu Y, et al. Cell Prolif, 2022 Jul. PMID 35642733, Free PMC Article
    2. DNA copy-number control through inhibition of replication fork progression. Nordman JT, et al. Cell Rep, 2014 Nov 6. PMID 25437540, Free PMC Article
    3. humpty dumpty is required for developmental DNA amplification and cell proliferation in Drosophila. Bandura JL, et al. Curr Biol, 2005 Apr 26. PMID 15854909
    4. Molecular cloning and genetic analysis of the suppressor-of-white-apricot locus from Drosophila melanogaster. Zachar Z, et al. Mol Cell Biol, 1987 Jul. PMID 3039348, Free PMC Article
    5. Localisation of the DmCdc45 DNA replication factor in the mitotic cycle and during chorion gene amplification. Loebel D, et al. Nucleic Acids Res, 2000 Oct 15. PMID 11024168, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show the structure of the Cdc45/Mcm2-7/Psf1 GINS (CMG) helicase in the presence of ATPgammaS and a DNA duplex bearing a 3' single-stranded tail.
      Title: DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA amplification IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in DNA replication IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication initiation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic DNA replication preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CMG complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of DNA replication preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DNA replication preinitiation complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell division cycle 45
    Names
    CDC45L
    CG3658-PA
    Cdc45-PA
    transcription unit D

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1028291..1030556 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130524.5 → NP_569880.1  cell division cycle 45 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569880.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96989
      Related
      FBpp0070175
      Conserved Domains (1) summary
      pfam02724
      Location:19 → 570
      CDC45; CDC45-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O96989 O96989

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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