U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Sarm Sterile alpha and Armadillo motif [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38895, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sarmprovided by FlyBase
    Official Full Name
    Sterile alpha and Armadillo motifprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262579
    Locus tag
    Dmel_CG43119
    See related
    AllianceGenome:FB:FBgn0262579
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.272; CG13680; CG13681; CG34373; CG43119; CG7905; CG7915; circRNA Edis; circ_1705; circ_Ect4; Dmel\CG43119; dsarm; dSarm; dSARM; dSarm1; dSARM1; ect4; Ect4; ECT4; Ect4/SARM; Edis; sarm; SARM; SARM1
    Old locus tag
    CG13680; CG7915; Dmel_CG13680; Dmel_CG13681; Dmel_CG34373; Dmel_CG7915
    Summary
    Enables NAD+ nucleosidase activity and STAT family protein binding activity. Involved in several processes, including NAD catabolic process; antiviral innate immune response; and positive regulation of receptor signaling pathway via STAT. Located in cytosol; neuron projection; and neuronal cell body. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; epithelium; gut section; and head epidermis primordium. Used to study neurodegenerative disease. Orthologous to human SARM1 (sterile alpha and TIR motif containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Sarm in Genome Data Viewer
    Location:
    66B4-66B6; 3-22 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8063874..8108897)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8056974..8101997)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Leucine-CAG 1-3 Neighboring gene transfer RNA:Leucine-CAG 1-4 Neighboring gene transfer RNA:Leucine-CAG 1-5 Neighboring gene transfer RNA:Leucine-CAG 1-6 Neighboring gene transfer RNA:Leucine-CAG 1-7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43974 Neighboring gene uncharacterized protein Neighboring gene mir-2501 stem loop Neighboring gene Nuclear localized protein 1 Neighboring gene farinelli

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    located_in cytosol PubMed 
    is_active_in dendrite  
    is_active_in mitochondrion PubMed 
    located_in neuron projection PubMed 
    located_in neuronal cell body PubMed 

    General protein information

    Preferred Names
    sterile alpha and armadillo motif
    Names
    CG43119-PD
    CG43119-PE
    CG43119-PF
    CG43119-PG
    CG43119-PH
    CG43119-PI
    CG43119-PJ
    CG43119-PK
    CG43119-PL
    CG43119-PM
    Ect4
    Ect4-derived immune suppressor
    Ectoderm-expressed 4
    SARM1
    Sarm-PD
    Sarm-PE
    Sarm-PF
    Sarm-PG
    Sarm-PH
    Sarm-PI
    Sarm-PJ
    Sarm-PK
    Sarm-PL
    Sarm-PM
    drosophila sterile alpha and armadillo motif
    sterile alpha, ARM, and TIR domain protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8063874..8108897
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259733.1 → NP_001246662.1  sterile alpha and armadillo motif, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246662.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NE45
      Conserved Domains (4) summary
      cd09501
      Location:1031 → 1099
      SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
      cd09502
      Location:1100 → 1169
      SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
      smart00454
      Location:1031 → 1096
      SAM; Sterile alpha motif
      pfam13676
      Location:1185 → 1285
      TIR_2; TIR domain
    2. NM_001274627.1 → NP_001261556.1  sterile alpha and armadillo motif, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261556.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHR5
      Conserved Domains (4) summary
      cd09501
      Location:1031 → 1099
      SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
      cd09502
      Location:1100 → 1169
      SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
      smart00454
      Location:1031 → 1096
      SAM; Sterile alpha motif
      pfam13676
      Location:1185 → 1285
      TIR_2; TIR domain
    3. NM_001104071.2 → NP_001097541.1  sterile alpha and armadillo motif, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097541.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNN1
      Conserved Domains (4) summary
      cd09501
      Location:938 → 1006
      SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
      cd09502
      Location:1007 → 1076
      SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
      smart00454
      Location:938 → 1003
      SAM; Sterile alpha motif
      pfam13676
      Location:1092 → 1192
      TIR_2; TIR domain
    4. NM_001104074.3 → NP_001097544.1  sterile alpha and armadillo motif, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097544.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNN2
      Conserved Domains (4) summary
      cd09501
      Location:863 → 931
      SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
      cd09502
      Location:932 → 1001
      SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
      smart00454
      Location:863 → 928
      SAM; Sterile alpha motif
      pfam13676
      Location:1017 → 1117
      TIR_2; TIR domain
    5. NM_001104075.2 → NP_001097545.1  sterile alpha and armadillo motif, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097545.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JNN3
      Conserved Domains (4) summary
      cd09501
      Location:687 → 755
      SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
      cd09502
      Location:756 → 825
      SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
      smart00454
      Location:687 → 752
      SAM; Sterile alpha motif
      pfam13676
      Location:841 → 941
      TIR_2; TIR domain
    6. NM_001043129.3 → NP_001036594.1  sterile alpha and armadillo motif, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036594.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E8H1, Q6IDD9, Q7KUA2, Q8SY48, Q9VSD2
      Conserved Domains (4) summary
      cd09501
      Location:687 → 755
      SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
      cd09502
      Location:756 → 825
      SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
      smart00454
      Location:687 → 752
      SAM; Sterile alpha motif
      pfam13676
      Location:841 → 941
      TIR_2; TIR domain
    7. NM_001259734.1 → NP_001246663.1  sterile alpha and armadillo motif, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246663.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFP2
      Conserved Domains (4) summary
      cd09501
      Location:687 → 755
      SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
      cd09502
      Location:756 → 825
      SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
      smart00454
      Location:687 → 752
      SAM; Sterile alpha motif
      pfam13676
      Location:841 → 941
      TIR_2; TIR domain
    8. NM_001382096.1 → NP_001369041.1  sterile alpha and armadillo motif, isoform L [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6M3Q7S1
      Conserved Domains (3) summary
      cd09501
      Location:505 → 573
      SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
      cd09502
      Location:574 → 643
      SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
      smart00255
      Location:658 → 795
      TIR; Toll - interleukin 1 - resistance
    9. NM_168254.2 → NP_729327.1  sterile alpha and armadillo motif, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729327.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6IDD9
      Related
      FBpp0293531
      Conserved Domains (4) summary
      cd09501
      Location:661 → 729
      SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
      cd09502
      Location:730 → 799
      SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
      smart00454
      Location:661 → 726
      SAM; Sterile alpha motif
      pfam13676
      Location:815 → 915
      TIR_2; TIR domain
    10. NM_001426711.1 → NP_001413639.1  sterile alpha and armadillo motif, isoform M [Drosophila melanogaster]

      Status: REVIEWED

    Loading
    Loading
    External link. Please review our privacy policy.