shtd shattered [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: shtdprovided by FlyBase
Official Full Name: shatteredprovided by FlyBase
Primary source: FLYBASE:FBgn0004391
Locus tag: Dmel_CG9198
See related: AllianceGenome:FB:FBgn0004391
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Apc1; APC1; APC1/shtd; CG9198; Dmel\CG9198; Shtd; SHTD
Summary: Predicted to enable molecular adaptor activity. Involved in anaphase-promoting complex-dependent catabolic process and compound eye development. Part of anaphase-promoting complex. Is expressed in cephalic furrow; eye disc; eye disc morphogenetic furrow; organism; and spermatozoon. Human ortholog(s) of this gene implicated in Rothmund-Thomson syndrome. Orthologous to human ANAPC1 (anaphase promoting complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (15455544..15462441, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (15349577..15356474, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

shtd encodes Apc1; reducing the dosage of either CycA or stg suppressed the shtd1 phenotype.
Title: Mutation of the Apc1 homologue shattered disrupts normal eye development by disrupting G1 cell cycle arrest and progression through mitosis.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in anaphase-promoting complex-dependent catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metaphase/anaphase transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cell cycle	HMP more info	PubMed
involved_in protein K11-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of anaphase-promoting complex	IBA Inferred from Biological aspect of Ancestor more info
part_of anaphase-promoting complex	IEA Inferred from Electronic Annotation more info
part_of anaphase-promoting complex	IGI Inferred from Genetic Interaction more info	PubMed
part_of anaphase-promoting complex	TAS Traceable Author Statement more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain