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    CG4168 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34889, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4168provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028888
    Locus tag
    Dmel_CG4168
    See related
    AllianceGenome:FB:FBgn0028888
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS03192.2; Dmel\CG4168
    Summary
    Is expressed in adult head. Human ortholog(s) of this gene implicated in COVID-19; X-Linked immunodeficiency 74; and primary immunodeficiency disease. Orthologous to several human genes including NRROS (negative regulator of reactive oxygen species); TLR7 (toll like receptor 7); and TLR8 (toll like receptor 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4168 in Genome Data Viewer
    Location:
    35C3-35C3; 2-51 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (15161882..15200459, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (15161882..15200459, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44771 Neighboring gene long non-coding RNA:CR44770 Neighboring gene long non-coding RNA:CR43357 Neighboring gene Seminal fluid protein 35C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Drosophila behavioral mutant, down and out (dao), is defective in an essential regulator of Erg potassium channels. Fergestad T, et al. Proc Natl Acad Sci U S A, 2010 Mar 23. PMID 20212103, Free PMC Article
    2. A natural genetic variation screen identifies insulin signaling, neuronal communication, and innate immunity as modifiers of hyperglycemia in the absence of Sirt1. Palu RAS, et al. G3 (Bethesda), 2022 May 30. PMID 35435227, Free PMC Article
    3. Drosophila convoluted/dALS is an essential gene required for tracheal tube morphogenesis and apical matrix organization. Swanson LE, et al. Genetics, 2009 Apr. PMID 19171940, Free PMC Article
    4. Belly roll, a GPI-anchored Ly6 protein, regulates Drosophila melanogaster escape behaviors by modulating the excitability of nociceptive peptidergic interneurons. Li K, et al. Elife, 2023 Jun 13. PMID 37309249, Free PMC Article
    5. Transposable element dynamics and PIWI regulation impacts lncRNA and gene expression diversity in Drosophila ovarian cell cultures. Sytnikova YA, et al. Genome Res, 2014 Dec. PMID 25267525, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4168-PB
    CG4168-PC
    chaoptic-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      15161882..15200459 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299024.1 → NP_001285953.1  uncharacterized protein Dmel_CG4168, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285953.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NK96, Q9VJQ0
      Conserved Domains (3) summary
      cd00116
      Location:315 → 546
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:640 → 663
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:784 → 843
      LRR_8; Leucine rich repeat

    2. NM_135896.6 → NP_609740.4  uncharacterized protein Dmel_CG4168, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609740.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NK96, Q9VJQ0
      Conserved Domains (3) summary
      cd00116
      Location:315 → 546
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:640 → 663
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:784 → 843
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZT2 Q8SZT2
    Q9VJQ0 Q9VJQ0

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