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    CG18659 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35929, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG18659provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027561
    Locus tag
    Dmel_CG18659
    See related
    AllianceGenome:FB:FBgn0027561
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.140; anon-WO0118547.145; BcDNA:GH08789; CG30347; CG30348; CG8059; Dmel\CG18659
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and phosphatidylinositol phosphate binding activity. Predicted to be involved in endocytic recycling; endocytosis; and regulation of Rab protein signal transduction. Predicted to be located in clathrin-coated vesicle. Predicted to be active in cytosol and intracellular membrane-bounded organelle. Is expressed in adult head and organism. Orthologous to human DENND1A (DENN domain containing 1A); DENND1B (DENN domain containing 1B); and DENND1C (DENN domain containing 1C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG18659 in Genome Data Viewer
    Location:
    45A9-45A10; 2-60 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9123304..9132030, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5010809..5019535, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Suppressor of variegation 2-10 Neighboring gene Phosphorylated adaptor for RNA export Neighboring gene Glutathione S transferase E13 Neighboring gene alpha/beta hydrolase 1 Neighboring gene alicorn Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. uDENN, DENN, and dDENN: indissociable domains in Rab and MAP kinases signaling pathways. Levivier E, et al. Biochem Biophys Res Commun, 2001 Sep 28. PMID 11563850
    2. HITS-CLIP reveals sex-differential RNA binding and alterative splicing regulation of SRm160 in Drosophila. Qiu C, et al. J Mol Cell Biol, 2019 Feb 1. PMID 29750417, Free PMC Article
    3. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. Yoshimura S, et al. J Cell Biol, 2010 Oct 18. PMID 20937701, Free PMC Article
    4. Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. Krauchunas AR, et al. Dev Biol, 2012 Oct 1. PMID 22884528, Free PMC Article
    5. Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling. Friedman AA, et al. Sci Signal, 2011 Oct 25. PMID 22028469, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of Rab protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in clathrin-coated vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG18659-PA
    CG18659-PC
    CG18659-PD
    CG18659-PE
    CG18659-PF
    CG18659-PH
    CG18659-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9123304..9132030 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259287.2 → NP_001246216.2  uncharacterized protein Dmel_CG18659, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246216.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K840, E4NKI4
      Conserved Domains (3) summary
      smart00801
      Location:315 → 379
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:10 → 95
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:98 → 282
      DENN; DENN (AEX-3) domain

    2. NM_001201961.2 → NP_001188890.1  uncharacterized protein Dmel_CG18659, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188890.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JD58
      Conserved Domains (3) summary
      smart00801
      Location:315 → 379
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:10 → 95
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:98 → 282
      DENN; DENN (AEX-3) domain

    3. NM_001259289.2 → NP_001246218.1  uncharacterized protein Dmel_CG18659, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246218.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV76
      Conserved Domains (3) summary
      smart00801
      Location:315 → 379
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:10 → 95
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:98 → 282
      DENN; DENN (AEX-3) domain

    4. NM_001201962.2 → NP_001188891.1  uncharacterized protein Dmel_CG18659, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188891.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JD05
      Conserved Domains (3) summary
      smart00801
      Location:315 → 379
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:10 → 95
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:98 → 282
      DENN; DENN (AEX-3) domain

    5. NM_136614.6 → NP_610458.2  uncharacterized protein Dmel_CG18659, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610458.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7Q6
      Conserved Domains (3) summary
      smart00801
      Location:315 → 379
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:10 → 95
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:98 → 282
      DENN; DENN (AEX-3) domain

    6. NM_145873.4 → NP_665880.2  uncharacterized protein Dmel_CG18659, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_665880.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7Q5
      Related
      FBpp0087707
      Conserved Domains (3) summary
      smart00801
      Location:315 → 379
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:10 → 95
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:98 → 282
      DENN; DENN (AEX-3) domain

    7. NM_001259288.2 → NP_001246217.1  uncharacterized protein Dmel_CG18659, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246217.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K840, E4NKI4
      Conserved Domains (3) summary
      smart00801
      Location:315 → 379
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:10 → 95
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:98 → 282
      DENN; DENN (AEX-3) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JD05 A0A0B4JD05
    A0A0B4JD58 A0A0B4JD58
    A0A0B4K840 A0A0B4K840
    A1Z7Q5 A1Z7Q5
    A1Z7Q6 A1Z7Q6
    C8VV76 C8VV76
    Q7KMK4 Q7KMK4

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