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    CG6707 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39168, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6707provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036058
    Locus tag
    Dmel_CG6707
    See related
    AllianceGenome:FB:FBgn0036058
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG6707
    Summary
    Predicted to enable phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to be active in bounding membrane of organelle and plasma membrane. Is expressed in adult head and organism. Orthologous to human PIP4P1 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1) and PIP4P2 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6707 in Genome Data Viewer
    Location:
    67D1-67D1; 3-32 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9894807..9898575, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9887907..9891675, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45875 Neighboring gene Calpain-B Neighboring gene uncharacterized protein Neighboring gene Hezron Neighboring gene uncharacterized protein Neighboring gene nudE Neighboring gene black match Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Roles of the Drosophila NudE protein in kinetochore function and centrosome migration. Wainman A, et al. J Cell Sci, 2009 Jun 1. PMID 19417004, Free PMC Article
    2. Genome-wide identification of direct targets of the Drosophila retinal determination protein Eyeless. Ostrin EJ, et al. Genome Res, 2006 Apr. PMID 16533912, Free PMC Article
    3. Hypoxia controls plasma membrane targeting of polarity proteins by dynamic turnover of PI4P and PI(4,5)P2. Lu J, et al. Elife, 2022 Jun 9. PMID 35678383, Free PMC Article
    4. A conserved myotubularin-related phosphatase regulates autophagy by maintaining autophagic flux. Allen EA, et al. J Cell Biol, 2020 Nov 2. PMID 32915229, Free PMC Article
    5. A genome engineering resource to uncover principles of cellular organization and tissue architecture by lipid signaling. Trivedi D, et al. Elife, 2020 Dec 15. PMID 33320085, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylinositol dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in phagocytic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6707-PA
    CG6707-PB
    CG6707-PC
    NP_648372.1
    NP_729575.1
    NP_729576.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9894807..9898575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140115.2 → NP_648372.1  uncharacterized protein Dmel_CG6707, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648372.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6SUZ8, Q9VT69
      Related
      FBpp0076085
      Conserved Domains (1) summary
      pfam09788
      Location:3 → 260
      Tmemb_55A; Transmembrane protein 55A

    2. NM_168388.2 → NP_729575.1  uncharacterized protein Dmel_CG6707, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729575.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6SUZ8, Q9VT69
      Related
      FBpp0076086
      Conserved Domains (1) summary
      pfam09788
      Location:3 → 260
      Tmemb_55A; Transmembrane protein 55A

    3. NM_168389.2 → NP_729576.1  uncharacterized protein Dmel_CG6707, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729576.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6SUZ8, Q9VT68
      Related
      FBpp0076087
      Conserved Domains (1) summary
      pfam09788
      Location:14 → 225
      Tmemb_55A; Transmembrane protein 55A
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VT68 Q9VT68
    Q9VT69 Q9VT69

    Gene LinkOut

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