kto kohtalo [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ktoprovided by FlyBase
Official Full Name: kohtaloprovided by FlyBase
Primary source: FLYBASE:FBgn0001324
Locus tag: Dmel_CG8491
See related: AllianceGenome:FB:FBgn0001324
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Brm @ Kto; CG8491; Dmel\CG8491; dTrap230; dTRAP230; Kto; KTO; Kto/Med12; l(3)76BDc; med12; Med12; MED12; med12/kto; psg14; siren1; SRB8; Srb8/KTO/TRAP230; Trap230
Summary: Enables transcription coregulator activity. Involved in several processes, including autophagic cell death; positive regulation of canonical Wnt signaling pathway; and sex comb development. Located in polytene chromosome. Part of CKM complex; core mediator complex; and mediator complex. Is expressed in embryonic/larval salivary gland; organism; and spermatozoon. Used to study obesity. Human ortholog(s) of this gene implicated in FG syndrome; leiomyosarcoma; major depressive disorder; phobic disorder; and syndromic X-linked intellectual disorder Lujan-Fryns-type. Orthologous to human MED12 (mediator complex subunit 12) and MED12L (mediator complex subunit 12L). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (19836614..19844944)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (19829714..19838044)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coregulator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coregulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in autophagic cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived leg segmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in response to ecdysone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sex comb development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CKM complex	IDA Inferred from Direct Assay more info	PubMed
part_of core mediator complex	IPI Inferred from Physical Interaction more info	PubMed
part_of mediator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mediator complex	IDA Inferred from Direct Assay more info	PubMed
part_of mediator complex	IEA Inferred from Electronic Annotation more info
part_of mediator complex	IPI Inferred from Physical Interaction more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed