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    Cyp303a1 Cytochrome P450 303a1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 49165, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp303a1provided by FlyBase
    Official Full Name
    Cytochrome P450 303a1provided by FlyBase
    Primary source
    FLYBASE:FBgn0001992
    Locus tag
    Dmel_CG4163
    See related
    AllianceGenome:FB:FBgn0001992
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    303a1; BG:DS02740.6; CG4163; Cyp303A1; CYP303A1; CYP303A1-Dm; Dmel\CG4163; I(2)35Fb; l(2)35Fb; nompH; nompH1
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Involved in sensory organ development. Is expressed in embryonic head; embryonic/larval tracheal section; ring gland; sense organ; and tormogen cell. Human ortholog(s) of this gene implicated in several diseases, including drug dependence (multiple); hypertension (multiple); neonatal abstinence syndrome; nicotine dependence; and renal fibrosis. Orthologous to human CYP2B6 (cytochrome P450 family 2 subfamily B member 6); CYP2J2 (cytochrome P450 family 2 subfamily J member 2); and CYP2W1 (cytochrome P450 family 2 subfamily W member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cyp303a1 in Genome Data Viewer
    Location:
    35F1-35F1; 2-52 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16294183..16296969)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16294183..16296969)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44899 Neighboring gene uncharacterized protein Neighboring gene heixuedian Neighboring gene uncharacterized protein Neighboring gene Glia maturation factor Neighboring gene crossover suppressor on 2 of Manheim Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CYP303A1 has a conserved function in adult eclosion in Locusta migratoria and Drosophila melanogaster. Wu L, et al. Insect Biochem Mol Biol, 2019 Oct. PMID 31422152
    2. Cyp6g2 is the major P450 epoxidase responsible for juvenile hormone biosynthesis in Drosophila melanogaster. Jia Q, et al. BMC Biol, 2024 May 13. PMID 38741075, Free PMC Article
    3. Association of detoxification enzymes with butene-fipronil in larvae and adults of Drosophila melanogaster. Arain MS, et al. Environ Sci Pollut Res Int, 2018 Apr. PMID 29380196
    4. The involvement of cytochrome P450 monooxygenases in methanol elimination in Drosophila melanogaster larvae. Wang SP, et al. Arch Insect Biochem Physiol, 2012 Apr. PMID 22508581
    5. A tissue specific cytochrome P450 required for the structure and function of Drosophila sensory organs. Willingham AT, et al. Mech Dev, 2004 Oct. PMID 15327788

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in sensory organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome P450 303a1
    Names
    CG4163-PA
    CG4163-PB
    Cyp303a1-PA
    Cyp303a1-PB
    lethal(2)35Fb
    NP_001285977.1
    NP_652070.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16294183..16296969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299048.1 → NP_001285977.1  cytochrome P450 303a1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285977.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V399
      UniProtKB/TrEMBL
      X2JA13
      Conserved Domains (1) summary
      pfam00067
      Location:28 → 480
      p450; Cytochrome P450

    2. NM_143813.3 → NP_652070.1  cytochrome P450 303a1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652070.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V399
      UniProtKB/TrEMBL
      X2JA13
      Related
      FBpp0080386
      Conserved Domains (1) summary
      pfam00067
      Location:28 → 480
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V399.1 Q9V399
    X2JA13 X2JA13

    Gene LinkOut

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