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    Art3 Arginine methyltransferase 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41837, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Art3provided by FlyBase
    Official Full Name
    Arginine methyltransferase 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0038306
    Locus tag
    Dmel_CG6563
    See related
    AllianceGenome:FB:FBgn0038306
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6563; DART3; Dmel\CG6563; PRMT3
    Summary
    Predicted to enable histone methyltransferase activity and protein-arginine omega-N monomethyltransferase activity. Predicted to be involved in chromatin remodeling and regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including anal pad primordium; anterior endoderm; embryonic anal pad; embryonic/larval midgut primordium; and gut section. Orthologous to human PRMT3 (protein arginine methyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Art3 in Genome Data Viewer
    Location:
    88E3-88E3; 3-56 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15227605..15229408, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11053327..11055130, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Chromatin assembly factor 1, p55 subunit Neighboring gene mitochondrial ribosomal protein S10 Neighboring gene antisense RNA:CR43471 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel BLAST-Based Relative Distance (BBRD) method can effectively group members of protein arginine methyltransferases and suggest their evolutionary relationship. Wang YC, et al. Mol Phylogenet Evol, 2015 Mar. PMID 25576770
    2. Evolutionarily conserved protein arginine methyltransferases in non-mammalian animal systems. Wang YC, et al. FEBS J, 2012 Mar. PMID 22251447
    3. Identification of genes involved in the same pathways using a Hidden Markov Model-based approach. Senf A, et al. Bioinformatics, 2009 Nov 15. PMID 19720676
    4. Upregulation of ribosome biogenesis via canonical E-boxes is required for Myc-driven proliferation. Zielke N, et al. Dev Cell, 2022 Apr 25. PMID 35472319
    5. Characterization of the Drosophila protein arginine methyltransferases DART1 and DART4. Boulanger MC, et al. Biochem J, 2004 Apr 15. PMID 14705965, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-arginine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-arginine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-arginine omega-N monomethyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-arginine methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    arginine methyltransferase 3
    Names
    Art3-PA
    Art3-PB
    CG6563-PA
    CG6563-PB
    NP_650434.1
    NP_731984.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15227605..15229408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142177.4 → NP_650434.1  arginine methyltransferase 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650434.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFB3
      Related
      FBpp0082588
      Conserved Domains (1) summary
      pfam12847
      Location:243 → 346
      Methyltransf_18; Methyltransferase domain

    2. NM_169623.4 → NP_731984.1  arginine methyltransferase 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731984.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8INE8
      Related
      FBpp0082589
      Conserved Domains (1) summary
      pfam12847
      Location:201 → 304
      Methyltransf_18; Methyltransferase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8INE8 Q8INE8
    Q9VFB3 Q9VFB3

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