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    Best4 Bestrophin 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39660, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Best4provided by FlyBase
    Official Full Name
    Bestrophin 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0036491
    Locus tag
    Dmel_CG7259
    See related
    AllianceGenome:FB:FBgn0036491
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7259; CT22395; dbest4; dBest4; Dmel\CG7259
    Summary
    Predicted to enable chloride channel activity. Predicted to be involved in chloride transport. Predicted to be located in plasma membrane. Orthologous to human BEST2 (bestrophin 2) and BEST4 (bestrophin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Best4 in Genome Data Viewer
    Location:
    71C2-71C2; 3-43 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15298958..15300942)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15292058..15294042)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Peroxiredoxin 1 Neighboring gene tollo Neighboring gene Bestrophin 3 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46213

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila bestrophin-1 chloride current is dually regulated by calcium and cell volume. Chien LT, et al. J Gen Physiol, 2007 Nov. PMID 17968025, Free PMC Article
    2. Molecular physiology of bestrophins: multifunctional membrane proteins linked to best disease and other retinopathies. Hartzell HC, et al. Physiol Rev, 2008 Apr. PMID 18391176
    3. Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells. Choksi SP, et al. Dev Cell, 2006 Dec. PMID 17141154
    4. Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior. Ceriani MF, et al. J Neurosci, 2002 Nov 1. PMID 12417656, Free PMC Article
    5. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chloride channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    bestrophin 4
    Names
    Best4-PB
    CG7259-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15298958..15300942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104139.2 → NP_001097609.1  bestrophin 4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097609.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1EC40, Q9VUM6
      Conserved Domains (1) summary
      pfam01062
      Location:8 → 319
      Bestrophin; Bestrophin, RFP-TM, chloride channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VUM6 Q9VUM6

    Gene LinkOut

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