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    CG5188 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34428, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5188provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032247
    Locus tag
    Dmel_CG5188
    See related
    AllianceGenome:FB:FBgn0032247
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5188; MAP1B
    Summary
    Predicted to enable metalloaminopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in mitochondrion. Is expressed in adult heart. Orthologous to human METAP1D (methionyl aminopeptidase type 1D, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5188 in Genome Data Viewer
    Location:
    31E1-31E1; 2-42 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10428829..10429988)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10428829..10429988)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Small ribonucleoprotein particle protein SmB Neighboring gene KDEL receptor Neighboring gene Basal body up regulated gene 22 Neighboring gene Transcription factor IIB Neighboring gene TBC1 domain family member 16 Neighboring gene hole-in-one

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of eukaryotic peptide deformylases reveals universality of N-terminal protein processing mechanisms. Giglione C, et al. EMBO J, 2000 Nov 1. PMID 11060042, Free PMC Article
    2. TDP-43 regulates Drosophila neuromuscular junctions growth by modulating Futsch/MAP1B levels and synaptic microtubules organization. Godena VK, et al. PLoS One, 2011 Mar 11. PMID 21412434, Free PMC Article
    3. Genome features of "Dark-fly", a Drosophila line reared long-term in a dark environment. Izutsu M, et al. PLoS One, 2012. PMID 22432011, Free PMC Article
    4. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TDP-43 physically interacts with futsch mRNA and that its RNA binding capacity is required to prevent futsch down regulation and synaptic defects.
      Title: TDP-43 regulates Drosophila neuromuscular junctions growth by modulating Futsch/MAP1B levels and synaptic microtubules organization.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloaminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5188-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10428829..10429988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135557.4 → NP_609401.2  uncharacterized protein Dmel_CG5188 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609401.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H1UUC3, Q9VKV9
      Related
      FBpp0079614
      Conserved Domains (1) summary
      cd01086
      Location:79 → 315
      MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZG2 Q8SZG2
    Q9VKV9 Q9VKV9

    Gene LinkOut

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