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    CG13850 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42630, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG13850provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038961
    Locus tag
    Dmel_CG13850
    See related
    AllianceGenome:FB:FBgn0038961
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG13850; GH07286p
    Summary
    Predicted to enable RNA binding activity. Involved in mitochondrial mRNA processing. Is active in mitochondrial matrix. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to human TBRG4 (transforming growth factor beta regulator 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG13850 in Genome Data Viewer
    Location:
    94A12-94A12; 3-74 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22408566..22410915, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18234288..18236637, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene transfer RNA:Serine-GCT 2-5 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene liquid facets-Related Neighboring gene Nop56

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RAP--a putative RNA-binding domain. Lee I, et al. Trends Biochem Sci, 2004 Nov. PMID 15501674
    2. Drosophila liquid facets-Related encodes Golgi epsin and is an essential gene required for cell proliferation, growth, and patterning. Lee JH, et al. Dev Biol, 2009 Jul 1. PMID 19376106, Free PMC Article
    3. Mechanisms underlying the cooperation between loss of epithelial polarity and Notch signaling during neoplastic growth in Drosophila. Logeay R, et al. Development, 2022 Feb 1. PMID 35005772
    4. ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing. Clemente P, et al. Nat Commun, 2022 Sep 30. PMID 36180430, Free PMC Article
    5. Temporal reciprocity of miRNAs and their targets during the maternal-to-zygotic transition in Drosophila. Bushati N, et al. Curr Biol, 2008 Apr 8. PMID 18394895

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial mRNA processing IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in mitochondrial mRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of mitochondrial mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitochondrial mRNA stability IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitochondrial mRNA stability ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial matrix IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG13850-PA
    CG13850-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22408566..22410915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142781.5 → NP_651038.3  uncharacterized protein Dmel_CG13850, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651038.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95U49, Q9VD14
      Conserved Domains (3) summary
      smart00952
      Location:498 → 556
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:319 → 385
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:402 → 484
      FAST_2; FAST kinase-like protein, subdomain 2

    2. NM_001275905.1 → NP_001262834.1  uncharacterized protein Dmel_CG13850, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262834.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95U49, Q9VD14
      Conserved Domains (3) summary
      smart00952
      Location:498 → 556
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:319 → 385
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:402 → 484
      FAST_2; FAST kinase-like protein, subdomain 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VD14 Q9VD14

    Gene LinkOut

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