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    Arl11 ADP-ribosylation factor-like 11 [ Mus musculus (house mouse) ]

    Gene ID: 219144, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Arl11provided by MGI
    Official Full Name
    ADP-ribosylation factor-like 11provided by MGI
    Primary source
    MGI:MGI:2444054
    See related
    Ensembl:ENSMUSG00000043157 AllianceGenome:MGI:2444054
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ARLTS1; C730007L20Rik
    Summary
    Predicted to enable GTP binding activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be active in cytoplasm. Is expressed in several structures, including clavicle; ganglia; incisor; liver lobe; and telencephalon ventricular layer. Orthologous to human ARL11 (ADP ribosylation factor like GTPase 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 5.9), lung adult (RPKM 1.6) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arl11 in Genome Data Viewer
    Location:
    14 D1; 14 32.66 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (61543740..61549386)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (61306290..61311937)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3, subunit E pseudogene Neighboring gene RIKEN cDNA 1700109G14 gene Neighboring gene STARR-seq mESC enhancer starr_36877 Neighboring gene predicted gene 5461 Neighboring gene emopamil binding protein-like Neighboring gene predicted gene, 25716

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
    2. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Ray JP, et al. Immunity, 2015 Oct 20. PMID 26410627, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ADP-ribosylation factor-like protein 11
    Names
    ADP-ribosylation factor-like tumor suppressor protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177337.3 → NP_796311.2  ADP-ribosylation factor-like protein 11

      See identical proteins and their annotated locations for NP_796311.2

      Status: VALIDATED

      Source sequence(s)
      BC064093
      Consensus CDS
      CCDS27182.1
      UniProtKB/Swiss-Prot
      Q6P3A9, Q8C7K1
      Related
      ENSMUSP00000055447.8, ENSMUST00000055159.8
      Conserved Domains (1) summary
      cl38936
      Location:14 → 169
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      61543740..61549386
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245028.3 → XP_011243330.1  ADP-ribosylation factor-like protein 11 isoform X1

      See identical proteins and their annotated locations for XP_011243330.1

      UniProtKB/Swiss-Prot
      Q6P3A9, Q8C7K1
      Conserved Domains (1) summary
      cl38936
      Location:14 → 169
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P3A9.1 GenPept UniProtKB/Swiss-Prot:Q6P3A9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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