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    Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 12258, updated on 9-Dec-2024

    Summary

    Official Symbol
    Serping1provided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade G, member 1provided by MGI
    Primary source
    MGI:MGI:894696
    See related
    Ensembl:ENSMUSG00000023224 AllianceGenome:MGI:894696
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C1nh; C1Inh; C1 Inh; C1INH.
    Summary
    Enables complement binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of complement activation, lectin pathway and negative regulation of endopeptidase activity. Located in extracellular space. Is expressed in several structures, including cerebral cortex; genitourinary system; notochord; pancreas mesenchyme; and visceral pericardium. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; angioedema (multiple); cerebral infarction; pancreatitis; and toxic shock syndrome. Orthologous to human SERPING1 (serpin family G member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver adult (RPKM 378.2), lung adult (RPKM 269.8) and 18 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Serping1 in Genome Data Viewer
    Location:
    2 D; 2 49.45 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (84595704..84605748, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (84765360..84775444, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene yippee like 4 Neighboring gene STARR-seq mESC enhancer starr_05008 Neighboring gene predicted gene, 19426 Neighboring gene microRNA 130a Neighboring gene STARR-seq mESC enhancer starr_05009 Neighboring gene STARR-seq mESC enhancer starr_05010 Neighboring gene predicted gene, 36596 Neighboring gene STARR-positive B cell enhancer ABC_E1592 Neighboring gene ubiquitin-conjugating enzyme E2L 6 Neighboring gene STARR-seq mESC enhancer starr_05011

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables complement binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables serine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fibrinolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of complement activation, lectin pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of complement activation, lectin pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    plasma protease C1 inhibitor
    Names
    C1 esterase inhibitor
    C1 inhibitor
    C1-inhibiting factor
    complement component 1 inhibitor
    serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1
    serine (or cysteine) proteinase inhibitor, clade G, member 1
    serpin G1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420027.1NP_001406956.1  plasma protease C1 inhibitor precursor

      Status: VALIDATED

      Source sequence(s)
      AL928914
      UniProtKB/Swiss-Prot
      A2ATR7, O88330, P97290, Q99M43, Q9QX09
    2. NM_001420028.1NP_001406957.1  plasma protease C1 inhibitor precursor

      Status: VALIDATED

      Source sequence(s)
      AL928914
      UniProtKB/Swiss-Prot
      A2ATR7, O88330, P97290, Q99M43, Q9QX09
    3. NM_009776.4NP_033906.2  plasma protease C1 inhibitor precursor

      See identical proteins and their annotated locations for NP_033906.2

      Status: VALIDATED

      Source sequence(s)
      AL928914
      Consensus CDS
      CCDS16193.1
      UniProtKB/Swiss-Prot
      A2ATR7, O88330, P97290, Q99M43, Q9QX09
      Related
      ENSMUSP00000023994.4, ENSMUST00000023994.10
      Conserved Domains (1) summary
      cd02050
      Location:141500
      serpinG1_C1-INH; serpin family G member 1, plasma proteinase C1 inhibitor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      84595704..84605748 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)