Oaz3 ornithine decarboxylase antizyme 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Oaz3provided by MGI
Official Full Name: ornithine decarboxylase antizyme 3provided by MGI
Primary source: MGI:MGI:1858170
See related: Ensembl:ENSMUSG00000028141 AllianceGenome:MGI:1858170
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AZ3; Az-3; Oaz-t
Summary: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 3, the third member of the antizyme family. Like antizymes 1 and 2, antizyme 3 inhibits ODC activity and polyamine uptake; however, it does not stimulate ODC degradation. Also, while antizymes 1 and 2 have broad tissue distribution, expression of antizyme 3 is restricted to haploid germ cells in testis, suggesting a distinct role for this antizyme in spermiogenesis. Antizyme 3 gene knockout studies showed that homozygous mutant male mice were infertile, and indicated the likely role of this antizyme in the formation of a rigid connection between the sperm head and tail during spermatogenesis. This transcript initiates translation from a non-AUG (CUG) codon that is highly conserved among the antizyme 3 orthologs. [provided by RefSeq, Dec 2014]
Expression: Restricted expression toward testis adult (RPKM 1411.8) See more
Orthologs: human all
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Genomic context

Location:: 3 F2.1; 3 40.66 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (94340694..94343958, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (94433387..94436651, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results indicated that OAZ-t is essential for the formation of a rigid junction between the head and tail during spermatogenesis.
Title: OAZ-t/OAZ3 is essential for rigid connection of sperm tails to heads in mouse.
results define the transcriptional regulatory elements of the OAZt gene promoter; an initiator, a downstream element, and two cyclic adenosine monophosphate-responsive element (CRE)-like sites in the upstream region
Title: Transient expression analysis of the mouse ornithine decarboxylase antizyme haploid-specific promoter using in vivo electroporation.
antizyme expression requires programmed, ribosomal frameshifting
Title: Discovery of a spermatogenesis stage-specific ornithine decarboxylase antizyme: antizyme 3.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Oaz3 (e-PCR), detects polymorphism
- UniSTS:531480

D3Umi3 (e-PCR), detects polymorphism
- UniSTS:280399

UniSTS:492264 (e-PCR)
- UniSTS:492264

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ankyrin repeat binding	ISO Inferred from Sequence Orthology more info
enables ornithine decarboxylase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ornithine decarboxylase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables ornithine decarboxylase inhibitor activity	IGI Inferred from Genetic Interaction more info
enables ornithine decarboxylase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of polyamine transmembrane transport	IDA Inferred from Direct Assay more info
involved_in polyamine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within polyamine metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of intracellular protein transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein catabolic process	IDA Inferred from Direct Assay more info
involved_in viral translational frameshifting	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ornithine decarboxylase antizyme 3

Names: ODC-Az 3; antizyme 3; testis specific ornithine decarboxylase antizyme

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.