TIFA TRAF interacting protein with forkhead associated domain [Homo sapiens (human)] - Gene

Summary

Official Symbol: TIFAprovided by HGNC
Official Full Name: TRAF interacting protein with forkhead associated domainprovided by HGNC
Primary source: HGNC:HGNC:19075
See related: Ensembl:ENSG00000145365 MIM:609028; AllianceGenome:HGNC:19075
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: T2BP; T6BP; TIFAA
Summary: This gene encodes an adapter protein involved in adaptive and innate immunity. This protein includes a forkhead-associated (FHA) domain that specifically binds to phosphorylated serine and threonine residues. In response to bacterial infection, the encoded host cell protein undergoes an intermolecular interaction between the FHA domain and a phosphorylated threonine that leads to protein oligomerization and stimulation of the NF-kappa B and other downstream signaling pathways. This protein exhibits reduced expression in hepatocellular carcinoma and may suppress hepatocellular carcinoma progression. This protein may also play a role in the DNA damage response. [provided by RefSeq, Jun 2018]
Expression: Ubiquitous expression in lymph node (RPKM 11.2), thyroid (RPKM 11.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4q25

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (112274537..112285904, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (115582899..115594247, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (113195693..113207060, complement)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The potential biomarker TIFA regulates pyroptosis in sepsis-induced acute kidney injury.
Title: The potential biomarker TIFA regulates pyroptosis in sepsis-induced acute kidney injury.
TIFA promotes colorectal cancer cell proliferation in an RSK- and PRAS40-dependent manner.
Title: TIFA promotes colorectal cancer cell proliferation in an RSK- and PRAS40-dependent manner.
TIFA protein expression is associated with pulmonary arterial hypertension.
Title: TIFA protein expression is associated with pulmonary arterial hypertension.
TIFA has dual functions in Helicobacter pylori-induced classical and alternative NF-kappaB pathways.
Title: TIFA has dual functions in Helicobacter pylori-induced classical and alternative NF-κB pathways.
TIFA and TIFAB: FHA-domain proteins involved in inflammation, hematopoiesis, and disease.
Title: TIFA and TIFAB: FHA-domain proteins involved in inflammation, hematopoiesis, and disease.
The ALPK1/TIFA/NF-kappaB axis links a bacterial carcinogen to R-loop-induced replication stress.
Title: The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress.
The results provide direct evidence and a structural basis for the TIFA-TRAF6 interaction, and show how this important biological function can be modulated.
Title: Binding and Enhanced Binding between Key Immunity Proteins TRAF6 and TIFA.
REVIEW: various mechanisms and pathways involved in H. pylori induction of NF-kappaB-dependent responses in gastric epithelial cells, including a 'state-of-the-art' review on the respective roles of NOD1 and ALPK1/TIFA pathways in these responses
Title: Role of NOD1 and ALPK1/TIFA Signalling in Innate Immunity Against Helicobacter pylori Infection.
TIFA expression limited proliferation of multiple myeloma cancer cells. In conclusion these results indicate that TIFA functions as a key transducer in DNA damage-induced NF-kappaB activation
Title: TRAF-interacting protein with forkhead-associated domain (TIFA) transduces DNA damage-induced activation of NF-κB.
TIFA may serve as a biomarker in the prediction of lung adenocarcinoma. Furthermore, TIFA may modulate lung cancer cell survival and proliferation through regulating the synthesis of apoptosis-associated proteins.
Title: TIFA Promotes Cell Survival and Migration in Lung Adenocarcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoplasmic pattern recognition receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoplasmic pattern recognition receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in protein homooligomerization	IDA Inferred from Direct Assay more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info

General protein information

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Preferred Names: TRAF-interacting protein with FHA domain-containing protein A

Names: TRAF-interacting protein with a forkhead-associated domain; TRAF2 binding protein; TRAF6 binding protein; putative MAPK-activating protein PM14; putative NF-kappa-B-activating protein 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_052864.3 → NP_443096.1 TRAF-interacting protein with FHA domain-containing protein A

See identical proteins and their annotated locations for NP_443096.1

Status: REVIEWED

Source sequence(s)

AB097011, AC109347, BM680110, BM718895, CA772080

Consensus CDS

CCDS34051.1

UniProtKB/Swiss-Prot

Q96CG3

Related

ENSP00000354911.2, ENST00000361717.4

Conserved Domains (1) summary

cd00060
Location:41 → 128

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...