U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    ZNF641 zinc finger protein 641 [ Homo sapiens (human) ]

    Gene ID: 121274, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZNF641provided by HGNC
    Official Full Name
    zinc finger protein 641provided by HGNC
    Primary source
    HGNC:HGNC:31834
    See related
    Ensembl:ENSG00000167528 MIM:613906; AllianceGenome:HGNC:31834
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal (RPKM 5.5), ovary (RPKM 3.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZNF641 in Genome Data Viewer
    Location:
    12q13.11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (48334587..48351246, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (48295893..48312553, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (48728370..48745029, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369753 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:48723521-48724020 Neighboring gene H1.7 linker histone Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6283 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:48744721-48745457 Neighboring gene olfactory receptor family 5 subfamily BK member 1 pseudogene Neighboring gene olfactory receptor family 5 subfamily BT member 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Interactions

    General gene information

    Clone Names

    • FLJ31295, DKFZp667D1012

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in cytosol  
    located_in nucleolus  
    is_active_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172681.2NP_001166152.1  zinc finger protein 641 isoform 2

      See identical proteins and their annotated locations for NP_001166152.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC024257, AY842285, BC018090
      Consensus CDS
      CCDS53788.1
      UniProtKB/Swiss-Prot
      Q96N77
      Related
      ENSP00000449974.1, ENST00000547026.6
      Conserved Domains (6) summary
      smart00349
      Location:95156
      KRAB; krueppel associated box
      COG5048
      Location:337416
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:252272
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:358380
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:95135
      KRAB; KRAB box
      pfam13465
      Location:264289
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001172682.2NP_001166153.1  zinc finger protein 641 isoform 3

      See identical proteins and their annotated locations for NP_001166153.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents use of an alternate transcription start site and 5' UTR, uses a downstream start codon, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus and lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AC024257, AK298064, DB445168
      Consensus CDS
      CCDS53787.1
      UniProtKB/Swiss-Prot
      Q96N77
      Related
      ENSP00000394627.3, ENST00000448928.7
      Conserved Domains (4) summary
      COG5048
      Location:328407
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:243263
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:255280
      zf-H2C2_2; Zinc-finger double domain
      cl25431
      Location:290
      PurL1; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]
    3. NM_001365803.1NP_001352732.1  zinc finger protein 641 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC024257
      Consensus CDS
      CCDS53787.1
      Conserved Domains (4) summary
      COG5048
      Location:328407
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:243263
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:255280
      zf-H2C2_2; Zinc-finger double domain
      cl25431
      Location:290
      PurL1; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]
    4. NM_001365804.1NP_001352733.1  zinc finger protein 641 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC024257
      Conserved Domains (2) summary
      PLN03206
      Location:290
      PLN03206; phosphoribosylformylglycinamidine synthase; Provisional
      smart00349
      Location:95156
      KRAB; krueppel associated box
    5. NM_001365805.1NP_001352734.1  zinc finger protein 641 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC024257, DA115635
      Conserved Domains (3) summary
      COG5048
      Location:194273
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:109129
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:121146
      zf-H2C2_2; Zinc-finger double domain
    6. NM_152320.3NP_689533.2  zinc finger protein 641 isoform 1

      See identical proteins and their annotated locations for NP_689533.2

      Status: VALIDATED

      Source sequence(s)
      AC024257, AK055857
      Consensus CDS
      CCDS8763.1
      UniProtKB/Swiss-Prot
      B3KS43, B4DNU5, Q8TCQ7, Q8WVE1, Q96N77
      Related
      ENSP00000301042.3, ENST00000301042.7
      Conserved Domains (6) summary
      smart00349
      Location:109170
      KRAB; krueppel associated box
      COG5048
      Location:351430
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:266286
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:372394
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:109149
      KRAB; KRAB box
      pfam13465
      Location:278303
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      48334587..48351246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005268640.6XP_005268697.1  zinc finger protein 641 isoform X4

      Conserved Domains (2) summary
      smart00349
      Location:109170
      KRAB; krueppel associated box
      pfam01352
      Location:109149
      KRAB; KRAB box
    2. XM_011537898.3XP_011536200.1  zinc finger protein 641 isoform X2

      See identical proteins and their annotated locations for XP_011536200.1

      UniProtKB/Swiss-Prot
      Q96N77
      Conserved Domains (6) summary
      smart00349
      Location:95156
      KRAB; krueppel associated box
      COG5048
      Location:337416
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:252272
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:358380
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:95135
      KRAB; KRAB box
      pfam13465
      Location:264289
      zf-H2C2_2; Zinc-finger double domain
    3. XM_005268638.5XP_005268695.1  zinc finger protein 641 isoform X2

      See identical proteins and their annotated locations for XP_005268695.1

      UniProtKB/Swiss-Prot
      Q96N77
      Conserved Domains (6) summary
      smart00349
      Location:95156
      KRAB; krueppel associated box
      COG5048
      Location:337416
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:252272
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:358380
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:95135
      KRAB; KRAB box
      pfam13465
      Location:264289
      zf-H2C2_2; Zinc-finger double domain
    4. XM_005268637.4XP_005268694.1  zinc finger protein 641 isoform X1

      Conserved Domains (4) summary
      COG5048
      Location:342421
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:257277
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:363385
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:269294
      zf-H2C2_2; Zinc-finger double domain
    5. XM_047428287.1XP_047284243.1  zinc finger protein 641 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      48295893..48312553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054371076.1XP_054227051.1  zinc finger protein 641 isoform X4

    2. XM_054371073.1XP_054227048.1  zinc finger protein 641 isoform X2

    3. XM_054371074.1XP_054227049.1  zinc finger protein 641 isoform X2

    4. XM_054371072.1XP_054227047.1  zinc finger protein 641 isoform X1

    5. XM_054371075.1XP_054227050.1  zinc finger protein 641 isoform X3

    External link. Please review our privacy policy.