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    LSM14B LSM family member 14B [ Homo sapiens (human) ]

    Gene ID: 149986, updated on 10-Dec-2024

    Summary

    Official Symbol
    LSM14Bprovided by HGNC
    Official Full Name
    LSM family member 14Bprovided by HGNC
    Primary source
    HGNC:HGNC:15887
    See related
    Ensembl:ENSG00000149657 MIM:620689; AllianceGenome:HGNC:15887
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FT005; LSM13; FAM61B; RAP55B; C20orf40; bA11M20.3
    Summary
    Enables RNA binding activity. Predicted to be involved in several processes, including maternal mRNA clearance; meiotic cell cycle process involved in oocyte maturation; and ovarian follicle development. Predicted to be located in cytoplasmic ribonucleoprotein granule. Predicted to be part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 18.4), brain (RPKM 13.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See LSM14B in Genome Data Viewer
    Location:
    20q13.33
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (62122475..62135374)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (63913343..63926242)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (60697531..60710430)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:60639656-60640169 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:60640170-60640684 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13095 Neighboring gene uncharacterized LOC105372705 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:60641713-60642226 Neighboring gene microRNA 3195 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60662279-60662835 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60662836-60663391 Neighboring gene uncharacterized LOC105372706 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60687696-60688502 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:60697043-60697730 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:60697731-60698419 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60698420-60699107 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60708899-60709398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13098 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13099 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13100 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13101 Neighboring gene Sharpr-MPRA regulatory region 1753 Neighboring gene proteasome 20S subunit alpha 7 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:60735092-60736291 Neighboring gene SS18L1 subunit of BAF chromatin remodeling complex Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60736587-60737199

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of LSM14B, SCD6 homolog B by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    General gene information

    Clone Names

    • FLJ25473, MGC61931

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding PubMed 
    enables mRNA binding  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in maternal mRNA clearance  
    involved_in meiotic cell cycle process involved in oocyte maturation  
    involved_in membraneless organelle assembly  
    involved_in oogenesis  
    involved_in ovarian follicle development  
    involved_in regulation of translation  
    Component Evidence Code Pubs
    located_in cytoplasmic ribonucleoprotein granule  
    part_of ribonucleoprotein complex  

    General protein information

    Preferred Names
    protein LSM14 homolog B
    Names
    LSM14 homolog B
    LSM14B, SCD6 homolog B
    RNA-associated protein 55B
    family with sequence similarity 61, member B
    hRAP55B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144703.3NP_653304.2  protein LSM14 homolog B

      See identical proteins and their annotated locations for NP_653304.2

      Status: VALIDATED

      Source sequence(s)
      AL137077, BC035702, BM547301, BX370449, BX375905, CX166280, DB336439
      Consensus CDS
      CCDS46626.1
      UniProtKB/Swiss-Prot
      Q6PFW8, Q96LH8, Q9BX40
      Related
      ENSP00000279068.5, ENST00000279068.11
      Conserved Domains (2) summary
      cd01736
      Location:679
      LSm14_N; Like-Sm protein 14, N-terminal domain
      pfam09532
      Location:248349
      FDF; FDF domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      62122475..62135374
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528605.3XP_011526907.1  protein LSM14 homolog B isoform X1

      See identical proteins and their annotated locations for XP_011526907.1

      Conserved Domains (2) summary
      pfam09532
      Location:349450
      FDF; FDF domain
      pfam12701
      Location:882
      LSM14; Scd6-like Sm domain
    2. XM_011528607.3XP_011526909.1  protein LSM14 homolog B isoform X3

      Conserved Domains (2) summary
      pfam09532
      Location:323424
      FDF; FDF domain
      pfam12701
      Location:882
      LSM14; Scd6-like Sm domain
    3. XM_011528608.3XP_011526910.1  protein LSM14 homolog B isoform X4

      Conserved Domains (2) summary
      cd01736
      Location:679
      LSm14_N; Like-Sm protein 14, N-terminal domain
      pfam09532
      Location:313414
      FDF; FDF domain
    4. XM_011528609.3XP_011526911.1  protein LSM14 homolog B isoform X6

      See identical proteins and their annotated locations for XP_011526911.1

      Conserved Domains (2) summary
      cd01736
      Location:679
      LSm14_N; Like-Sm protein 14, N-terminal domain
      pfam09532
      Location:274375
      FDF; FDF domain
    5. XM_024451839.2XP_024307607.1  protein LSM14 homolog B isoform X7

      Conserved Domains (2) summary
      cd01736
      Location:679
      LSm14_N; Like-Sm protein 14, N-terminal domain
      pfam09532
      Location:248349
      FDF; FDF domain
    6. XM_011528606.4XP_011526908.1  protein LSM14 homolog B isoform X2

      Conserved Domains (2) summary
      pfam09532
      Location:323424
      FDF; FDF domain
      pfam12701
      Location:882
      LSM14; Scd6-like Sm domain
    7. XM_005260302.4XP_005260359.1  protein LSM14 homolog B isoform X5

      See identical proteins and their annotated locations for XP_005260359.1

      Conserved Domains (2) summary
      cd01736
      Location:679
      LSm14_N; Like-Sm protein 14, N-terminal domain
      pfam09532
      Location:287388
      FDF; FDF domain
    8. XM_011528611.4XP_011526913.1  protein LSM14 homolog B isoform X9

      See identical proteins and their annotated locations for XP_011526913.1

      Conserved Domains (2) summary
      cd01736
      Location:679
      LSm14_N; Like-Sm protein 14, N-terminal domain
      pfam09532
      Location:222323
      FDF; FDF domain
    9. XM_047439933.1XP_047295889.1  protein LSM14 homolog B isoform X8

    10. XM_024451841.2XP_024307609.1  protein LSM14 homolog B isoform X11

      Conserved Domains (1) summary
      pfam09532
      Location:203304
      FDF; FDF domain
    11. XM_011528612.3XP_011526914.1  protein LSM14 homolog B isoform X10

      See identical proteins and their annotated locations for XP_011526914.1

      Conserved Domains (1) summary
      pfam09532
      Location:204305
      FDF; FDF domain
    12. XM_047439934.1XP_047295890.1  protein LSM14 homolog B isoform X8

    13. XM_024451840.2XP_024307608.1  protein LSM14 homolog B isoform X10

      Conserved Domains (1) summary
      pfam09532
      Location:204305
      FDF; FDF domain
    14. XM_011528613.3XP_011526915.1  protein LSM14 homolog B isoform X12

      See identical proteins and their annotated locations for XP_011526915.1

      UniProtKB/TrEMBL
      Q5TBP9
      Related
      ENSP00000355209.3, ENST00000361670.3
      Conserved Domains (1) summary
      pfam09532
      Location:168269
      FDF; FDF domain
    15. XM_047439935.1XP_047295891.1  protein LSM14 homolog B isoform X13

    RNA

    1. XR_936508.3 RNA Sequence

    2. XR_936509.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      63913343..63926242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054323086.1XP_054179061.1  protein LSM14 homolog B isoform X1

    2. XM_054323088.1XP_054179063.1  protein LSM14 homolog B isoform X3

    3. XM_054323089.1XP_054179064.1  protein LSM14 homolog B isoform X4

    4. XM_054323091.1XP_054179066.1  protein LSM14 homolog B isoform X6

    5. XM_054323092.1XP_054179067.1  protein LSM14 homolog B isoform X7

    6. XM_054323087.1XP_054179062.1  protein LSM14 homolog B isoform X2

    7. XM_054323090.1XP_054179065.1  protein LSM14 homolog B isoform X5

    8. XM_054323093.1XP_054179068.1  protein LSM14 homolog B isoform X9

    9. XM_054323095.1XP_054179070.1  protein LSM14 homolog B isoform X10

    10. XM_054323097.1XP_054179072.1  protein LSM14 homolog B isoform X12

      UniProtKB/TrEMBL
      Q5TBP9
    11. XM_054323094.1XP_054179069.1  protein LSM14 homolog B isoform X10

    12. XM_054323096.1XP_054179071.1  protein LSM14 homolog B isoform X11

    13. XM_054323098.1XP_054179073.1  protein LSM14 homolog B isoform X13

    RNA

    1. XR_008485239.1 RNA Sequence

    2. XR_008485240.1 RNA Sequence

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