Vbp1 von Hippel-Lindau binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vbp1provided by MGI
Official Full Name: von Hippel-Lindau binding protein 1provided by MGI
Primary source: MGI:MGI:1333804
See related: Ensembl:ENSMUSG00000031197 AllianceGenome:MGI:1333804
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: VBP-1
Summary: Predicted to enable amyloid-beta binding activity; tubulin binding activity; and unfolded protein binding activity. Predicted to be involved in several processes, including negative regulation of amyloid fibril formation; protein folding; and tubulin complex assembly. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be part of prefoldin complex. Predicted to be active in cytoplasm. Is expressed in several structures, including genitourinary system; gut; heart; nervous system; and sensory organ. Orthologous to human VBP1 (VHL binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E18 (RPKM 30.1), CNS E14 (RPKM 25.7) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A7.3; X 38.25 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (74557903..74578552)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (75514297..75534946)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Vbp1 (e-PCR), detects polymorphism
- UniSTS:243274

Vbp1 (e-PCR), detects polymorphism
- UniSTS:144745

Vbp1 (e-PCR), detects polymorphism
- UniSTS:516727

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables amyloid-beta binding	IEA Inferred from Electronic Annotation more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in microtubule-based process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of amyloid fibril formation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein folding	ISO Inferred from Sequence Orthology more info
involved_in tubulin complex assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed
part_of prefoldin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of prefoldin complex	IEA Inferred from Electronic Annotation more info
part_of prefoldin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prefoldin subunit 3

Names: VHL-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011692.2 → NP_035822.2 prefoldin subunit 3

See identical proteins and their annotated locations for NP_035822.2

Status: VALIDATED

Source sequence(s)

AK077923, BY134471, BY476349, DV066998

Consensus CDS

CCDS41032.1

UniProtKB/Swiss-Prot

P61759, Q3U6M9, Q9CPZ0

UniProtKB/TrEMBL

A3KMJ8

Related

ENSMUSP00000033540.6, ENSMUST00000033540.6

Conserved Domains (1) summary

cd00584
Location:49 → 180

Prefoldin_alpha; Prefoldin alpha subunit; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta ...