MDM2 MDM2 proto-oncogene [Homo sapiens (human)] - Gene

Summary

Official Symbol: MDM2provided by HGNC
Official Full Name: MDM2 proto-oncogeneprovided by HGNC
Primary source: HGNC:HGNC:6973
See related: Ensembl:ENSG00000135679 MIM:164785; AllianceGenome:HGNC:6973
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HDMX; LSKB; hdm2; ACTFS
Summary: This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
Expression: Ubiquitous expression in colon (RPKM 13.6), bone marrow (RPKM 9.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q15

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (68808172..68850686)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (68784018..68830265)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (69201952..69244466)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Working title: Molecular involvement of p53-MDM2 interactome in gastrointestinal cancers.
Title: Working title: Molecular involvement of p53-MDM2 interactome in gastrointestinal cancers.
TARDBP drives T-cell acute lymphoblastic leukemia progression by binding MDM2 mRNA, involving beta-catenin pathway.
Title: TARDBP drives T-cell acute lymphoblastic leukemia progression by binding MDM2 mRNA, involving β-catenin pathway.
HADHA promotes glioma progression by accelerating MDM2-mediated p53 ubiquitination.
Title: HADHA promotes glioma progression by accelerating MDM2-mediated p53 ubiquitination.
MDM2 Is Essential to Maintain the Homeostasis of Epithelial Cells by Targeting p53.
Title: MDM2 Is Essential to Maintain the Homeostasis of Epithelial Cells by Targeting p53.
Ribosomal Protein S4 X-Linked as a Novel Modulator of MDM2 Stability by Suppressing MDM2 Auto-Ubiquitination and SCF Complex-Mediated Ubiquitination.
Title: Ribosomal Protein S4 X-Linked as a Novel Modulator of MDM2 Stability by Suppressing MDM2 Auto-Ubiquitination and SCF Complex-Mediated Ubiquitination.
Expression profile of tumour suppressor protein p53 and its regulator MDM2 in a cohort of breast cancer patients in a Tertiary Hospital in Ghana.
Title: Expression profile of tumour suppressor protein p53 and its regulator MDM2 in a cohort of breast cancer patients in a Tertiary Hospital in Ghana.
Peculiar nuclear atypia associated with MDM2 gene amplification in carcinoma ex-pleomorphic adenoma harbouring an alteration of HMGA2.
Title: Peculiar nuclear atypia associated with MDM2 gene amplification in carcinoma ex-pleomorphic adenoma harbouring an alteration of HMGA2.
Induction of the Mdm2 gene and protein by kinase signaling pathways is repressed by the pVHL tumor suppressor.
Title: Induction of the Mdm2 gene and protein by kinase signaling pathways is repressed by the pVHL tumor suppressor.
FOXO1 promotes cancer cell growth through MDM2-mediated p53 degradation.
Title: FOXO1 promotes cancer cell growth through MDM2-mediated p53 degradation.
Association of MDM2 Overexpression in Ameloblastomas with MDM2 Amplification and BRAF[V600E] Expression.
Title: Association of MDM2 Overexpression in Ameloblastomas with MDM2 Amplification and BRAF(V600E) Expression.

Submit: New GeneRIF Correction See all GeneRIFs (1403)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Accelerated tumor formation, susceptibility to MedGen: C3280690 OMIM: 614401 GeneReviews: Not available	not available
Lessel-kubisch syndrome MedGen: C5231460 OMIM: 618681 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
A genome-wide association study identifies susceptibility loci of silica related pneumoconiosis in Han Chinese. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Ubiquitination of HIV-1 Tat by Hdm2 is required for efficient replication of HIV-1, indicating Hdm2 regulates Tat function and is a Tat co-activator	PubMed
	tat	Hdm2 interacts directly with HIV-1 Tat and ubiquitinates Tat on amino acid residue Lys71	PubMed
Vif	vif	HIV-1 Vif interacts with MDM2, which can be inhibited through mutating amino acids E88, W89, L64, or I66 in MDM2, R93 in Vif, or by increasing CBF-B expression	PubMed
	vif	MDM2 reduces cellular Vif levels and reversely increases A3G levels, because the interaction between MDM2 and Vif prevents A3G from binding to Vif	PubMed
	vif	MDM2 inhibits HIV-1 replication in non-permissive target cells through Vif degradation	PubMed
	vif	The N-terminal region (residues 1-50) of HIV-1 Vif is important for binding to MDM2. The interaction domain of MDM2 with Vif to amino-acids 168-320, which are located in its central acidic and zinc-finger domains	PubMed
	vif	HIV-1 Vif stabilizes TP53 by blocking MDM2-induced ubiquitination and inhibits MDM2-mediated nuclear export of TP53, leading to support viral replication through inducing G2 cell cycle arrest	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH93271 (e-PCR)
- UniSTS:91925

G66928 (e-PCR)
- UniSTS:166955

G66929 (e-PCR)
- UniSTS:166956

RH45825 (e-PCR)
- UniSTS:69681

D8S2278 (e-PCR)
- UniSTS:473906

SGC38056 (e-PCR)
- UniSTS:50520

GDB:451622 (e-PCR)
- UniSTS:157329

RH45597 (e-PCR)
- UniSTS:9389

RH65828 (e-PCR)
- UniSTS:187

STS-H58373 (e-PCR)
- UniSTS:71615

GDB:371587 (e-PCR)
- UniSTS:156866

RH44942 (e-PCR)
- UniSTS:6610

RH11003 (e-PCR)
- UniSTS:87522

PMC100259P1 (e-PCR)
- UniSTS:270055

MDM2_1161 (e-PCR)
- UniSTS:277486

PMC129072P1 (e-PCR)
- UniSTS:270587

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 5S rRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables NEDD8 ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables SUMO transferase activity	EXP Inferred from Experiment more info	PubMed
enables disordered domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables p53 binding	IPI Inferred from Physical Interaction more info	PubMed
enables peroxisome proliferator activated receptor binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor serine/threonine kinase binding	IEA Inferred from Electronic Annotation more info
enables ribonucleoprotein complex binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ubiquitin protein ligase activity	TAS Traceable Author Statement more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amyloid fibril formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in atrial septum development	IEA Inferred from Electronic Annotation more info
involved_in atrioventricular valve morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in blood vessel development	IEA Inferred from Electronic Annotation more info
involved_in blood vessel remodeling	IEA Inferred from Electronic Annotation more info
involved_in cardiac septum morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cellular response to UV-C	IEA Inferred from Electronic Annotation more info
involved_in cellular response to actinomycin D	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to alkaloid	IEA Inferred from Electronic Annotation more info
involved_in cellular response to estrogen stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to gamma radiation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to peptide hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to vitamin B1	IEA Inferred from Electronic Annotation more info
involved_in endocardial cushion morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in fibroblast activation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein processing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of signal transduction by p53 class mediator	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of signal transduction by p53 class mediator	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular associated smooth muscle cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	TAS Traceable Author Statement more info	PubMed
involved_in protein autoubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein destabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	TAS Traceable Author Statement more info	PubMed
involved_in protein sumoylation	TAS Traceable Author Statement more info
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis involved in protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of heart rate	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic neurotransmitter receptor internalization	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein catabolic process at postsynapse, modulating synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in response to antibiotic	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cocaine	IEA Inferred from Electronic Annotation more info
involved_in response to ether	IEA Inferred from Electronic Annotation more info
involved_in response to formaldehyde	IEA Inferred from Electronic Annotation more info
involved_in response to iron ion	IEA Inferred from Electronic Annotation more info
involved_in response to magnesium ion	IEA Inferred from Electronic Annotation more info
involved_in response to steroid hormone	IEA Inferred from Electronic Annotation more info
involved_in response to toxic substance	IEA Inferred from Electronic Annotation more info
involved_in response to water-immersion restraint stress	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in traversing start control point of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventricular septum development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in endocytic vesicle membrane	TAS Traceable Author Statement more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
colocalizes_with nuclear body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of transcription repressor complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase Mdm2

Names: MDM2 oncogene, E3 ubiquitin protein ligase; MDM2 proto-oncogene, E3 ubiquitin protein ligase; Mdm2, p53 E3 ubiquitin protein ligase homolog; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; double minute 2, human homolog of; p53-binding protein; oncoprotein Mdm2

NP_001138809.1

EC 2.3.2.27

NP_001138811.1

EC 2.3.2.27

NP_001138812.1

EC 2.3.2.27

NP_001265391.1

EC 2.3.2.27

NP_001354919.1

EC 2.3.2.27

NP_002383.2

EC 2.3.2.27

XP_047284809.1

EC 2.3.2.27

XP_054228034.1

EC 2.3.2.27

XP_054228035.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016708.2 RefSeqGene

Range

5007..42374

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001145337.3 → NP_001138809.1 E3 ubiquitin-protein ligase Mdm2 isoform g

See identical proteins and their annotated locations for NP_001138809.1

Status: REVIEWED

Description

Transcript Variant: This variant (3, also known as P2-MDM2-10) contains multiple differences in the 5' UTR and coding region, compared to variant 1. It uses an alternate promoter and initiates translation at a downstream in-frame start codon. The encoded isoform (g) has a shorter N-terminus and is shorter than isoform a.

Source sequence(s)

AC025423, BE930512, EU076747, EU076748

UniProtKB/TrEMBL

A0A0A8KB70, A0A0A8KB75

Conserved Domains (3) summary

cd17672
Location:25 → 107

MDM2; p53-binding domain found in E3 ubiquitin-protein ligase MDM2 and similar proteins

pfam00641
Location:252 → 281

zf-RanBP; Zn-finger in Ran binding protein and others

cd16783
Location:388 → 444

mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins
NM_001145339.2 → NP_001138811.1 E3 ubiquitin-protein ligase Mdm2 isoform h

See identical proteins and their annotated locations for NP_001138811.1

Status: REVIEWED

Description

Transcript Variant: This variant (2, also known as MDM2g) lacks two coding exons, but maintains the reading frame, compared to variant 1. The encoded isoform (h) is shorter than isoform a.

Source sequence(s)

AC025423, AF092844, BE930512, HY174841

UniProtKB/TrEMBL

A8WFP2, G3XA89

Related

ENSP00000258148.7, ENST00000258148.11

Conserved Domains (3) summary

pfam00641
Location:250 → 279

zf-RanBP; Zn-finger in Ran binding protein and others

pfam02201
Location:51 → 98

SWIB; SWIB/MDM2 domain

pfam13920
Location:387 → 434

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
NM_001145340.3 → NP_001138812.1 E3 ubiquitin-protein ligase Mdm2 isoform i

Status: REVIEWED

Description

Transcript Variant: This variant (4, also known as P2-MDM2-C1) contains multiple differences in the 5' UTR and coding region, compared to variant 1. It uses an alternate promoter and initiates translation at a downstream in-frame start codon. The encoded isoform (i) has a shorter N-terminus and is shorter than isoform a.

Source sequence(s)

AC025423, AF385327, BE930512, EU076746

UniProtKB/TrEMBL

A0A0C4DFR5

Related

ENSP00000335096.4, ENST00000348801.7

Conserved Domains (3) summary

COG5271
Location:41 → 231

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

pfam00641
Location:104 → 132

zf-RanBP; Zn-finger in Ran binding protein and others

cd16783
Location:239 → 295

mRING-HC-C2H2C4_MDM2; Modified RING finger, HC subclass (C2H2C4-type), found in E3 ubiquitin-protein ligase MDM2 and similar proteins
NM_001278462.2 → NP_001265391.1 E3 ubiquitin-protein ligase Mdm2 isoform l

See identical proteins and their annotated locations for NP_001265391.1

Status: REVIEWED

Description

Transcript Variant: This variant (5, also known as P2-MDM2-C) contains multiple differences in the 5' UTR and coding region, compared to variant 1. It uses an alternate promoter and initiates translation at a downstream in-frame start codon. The encoded isoform (l) has a shorter N-terminus and is shorter than isoform a.

Source sequence(s)

AC025423, AF385327, AK290341, BE930512, EU076748

Consensus CDS

CCDS61189.1

UniProtKB/TrEMBL

A0A0C4DFR5

Related

ENSP00000299252.4, ENST00000299252.8

Conserved Domains (2) summary

pfam00641
Location:129 → 158

zf-RanBP; Zn-finger in Ran binding protein and others

pfam13920
Location:266 → 313

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
NM_001367990.1 → NP_001354919.1 E3 ubiquitin-protein ligase Mdm2 isoform 2

Status: REVIEWED

Source sequence(s)

AC025423

Consensus CDS

CCDS91724.1

UniProtKB/Swiss-Prot

A6NL51, A8K2S6, Q00987, Q13226, Q13297, Q13298, Q13299, Q13300, Q13301, Q53XW0, Q71TW9, Q8WYJ1, Q8WYJ2, Q9UGI3, Q9UMT8

UniProtKB/TrEMBL

A8WFP2

Related

ENSP00000444430.2, ENST00000539479.6
NM_002392.6 → NP_002383.2 E3 ubiquitin-protein ligase Mdm2 isoform a

See identical proteins and their annotated locations for NP_002383.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC025423

Consensus CDS

CCDS8986.2

UniProtKB/TrEMBL

A8WFP2

Related

ENSP00000258149.6, ENST00000258149.11

Conserved Domains (3) summary

pfam00641
Location:305 → 334

zf-RanBP; Zn-finger in Ran binding protein and others

pfam02201
Location:51 → 98

SWIB; SWIB/MDM2 domain

pfam13920
Location:442 → 489

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

68808172..68850686

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047428853.1 → XP_047284809.1 E3 ubiquitin-protein ligase Mdm2 isoform X1

UniProtKB/TrEMBL

J3KN53

Alternate T2T-CHM13v2.0

Genomic

NC_060936.1 Alternate T2T-CHM13v2.0

Range

68784018..68830265

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054372059.1 → XP_054228034.1 E3 ubiquitin-protein ligase Mdm2 isoform X2

UniProtKB/TrEMBL

A8WFP2
XM_054372060.1 → XP_054228035.1 E3 ubiquitin-protein ligase Mdm2 isoform X1

UniProtKB/TrEMBL

J3KN53

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001145336.1: Suppressed sequence

Description

NM_001145336.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
NM_006878.3: Suppressed sequence

Description

NM_006878.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which lacks consecutive internal exons and contains non-consensus splice sites, compared to the reported wild-type transcript.
NM_006879.3: Suppressed sequence

Description

NM_006879.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which lacks consecutive internal exons and contains non-consensus splice sites, compared to the reported wild-type transcript.
NM_006880.2: Suppressed sequence

Description

NM_006880.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
NM_006881.3: Suppressed sequence

Description

NM_006881.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which lacks consecutive internal exons and contains non-consensus splice sites, compared to the reported wild-type transcript.
NM_006882.3: Suppressed sequence

Description

NM_006882.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which lacks consecutive internal exons and contains non-consensus splice sites, compared to the reported wild-type transcript.
NM_032739.1: Suppressed sequence

Description

NM_032739.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.