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    ST13 ST13 Hsp70 interacting protein [ Homo sapiens (human) ]

    Gene ID: 6767, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ST13provided by HGNC
    Official Full Name
    ST13 Hsp70 interacting proteinprovided by HGNC
    Primary source
    HGNC:HGNC:11343
    See related
    Ensembl:ENSG00000100380 MIM:606796; AllianceGenome:HGNC:11343
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HIP; HOP; P48; AAG2; SNC6; HSPABP; FAM10A1; FAM10A4; HSPABP1; PRO0786
    Summary
    The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
    Expression
    Ubiquitous expression in ovary (RPKM 177.9), kidney (RPKM 97.3) and 25 other tissues See more
    Orthologs
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    Genomic context

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    See ST13 in Genome Data Viewer
    Location:
    22q13.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (40824535..40856639, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (41296730..41328831, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (41220539..41252643, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 17 Neighboring gene jumping translocation breakpoint pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19100 Neighboring gene microRNA 4766 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:41252371-41253140 Neighboring gene X-prolyl aminopeptidase 3 Neighboring gene DnaJ heat shock protein family (Hsp40) member B7 Neighboring gene uncharacterized LOC124905124

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ST13 polymorphisms and their effect on exacerbations in steroid-treated asthmatic children and young adults. Vijverberg SJ, et al. Clin Exp Allergy, 2015 Jun. PMID 25616159, Free PMC Article
    2. Molecular cloning of human p48, a transient component of progesterone receptor complexes and an Hsp70-binding protein. Prapapanich V, et al. Mol Endocrinol, 1996 Apr. PMID 8721986
    3. Characterization of colorectal-cancer-related cDNA clones obtained by subtractive hybridization screening. Cao J, et al. J Cancer Res Clin Oncol, 1997. PMID 9292708
    4. [Differential expression of HSU17714 gene in colorectal cancer and normal colonic mucosa]. Mo Y, et al. Zhonghua Zhong Liu Za Zhi, 1996 Jul. PMID 9387309
    5. Screening and identification of down-regulated genes in colorectal carcinoma by subtractive hybridization: a method to identify putative tumor suppressor genes. Zheng S, et al. Chin Med J (Engl), 1997 Jul. PMID 9594214

    See all (131) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Polymorphism in Genes Encoding Adaptor Proteins ST13 and STIP1 and the Risk of Ischemic Stroke: a Pilot Study.
      Title: Polymorphism in Genes Encoding Adaptor Proteins ST13 and STIP1 and the Risk of Ischemic Stroke: a Pilot Study.
    2. An autophagy-related model of 4 key genes for predicting prognosis of patients with laryngeal cancer.
      Title: An autophagy-related model of 4 key genes for predicting prognosis of patients with laryngeal cancer.
    3. A novel susceptibility gene, ST13, coding for a cochaperone of the glucocorticoid receptor, is associated with exacerbations in asthmatic children and young adults despite their ICS use.
      Title: ST13 polymorphisms and their effect on exacerbations in steroid-treated asthmatic children and young adults.
    4. St13 is a proliferation regulator that inhibits tumor growth in colorectal neoplasms and may affect cell migration.
      Title: ST13, a proliferation regulator, inhibits growth and migration of colorectal cancer cell lines.
    5. Akt phosphorylation at Thr308 and Ser473 is required for CHIP-mediated ubiquitination of the kinase.
      Title: Akt phosphorylation at Thr308 and Ser473 is required for CHIP-mediated ubiquitination of the kinase.
    6. A single amino acid substitution (L211S) resulted in a loss of Hip function. This mutation also appears to disrupt the interaction of Hip with Hsp70 in vitro
      Title: Single-point mutation in a conserved TPR domain of Hip disrupts enhancement of glucocorticoid receptor signaling.
    7. Hip has been identified as a novel substrate of GRK5 in vitro and in cells, and phosphorylation of Hip by GRK5 plays a role in modulating CXCR4 internalization
      Title: G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4.
    8. These results strongly indicate ST13 mediated by adenovirus triggers colorectal cell apoptosis via ASK1-JNK signaling cascade
      Title: ASK1-JNK signaling cascade mediates Ad-ST13-induced apoptosis in colorectal HCT116 cells.
    9. S-nitrosoglutathione corrects DeltaF508 CFTR trafficking by inhibiting Hop expression
      Title: Hsp 70/Hsp 90 organizing protein as a nitrosylation target in cystic fibrosis therapy.
    10. The expression levels of ST13 cannot serve as a biomarker for early stages of PD.
      Title: Expression analysis of suppression of tumorigenicity 13 gene in patients with Parkinson's disease.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ27260, MGC129952

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in extracellular exosome HDA PubMed 

    General protein information

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    Preferred Names
    hsc70-interacting protein
    Names
    Hsp70-interacting protein
    aging-associated protein 2
    heat shock 70kD protein binding protein
    progesterone receptor-associated p48 protein
    putative tumor suppressor ST13
    renal carcinoma antigen NY-REN-33
    suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
    suppression of tumorigenicity 13 protein
    testis secretory sperm-binding protein Li 233m

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278589.2 → NP_001265518.1  hsc70-interacting protein isoform 2

      See identical proteins and their annotated locations for NP_001265518.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK303530, BM679025, Z98048
      UniProtKB/Swiss-Prot
      Q8NFI4
      UniProtKB/TrEMBL
      B4E0U6
      Conserved Domains (5) summary
      smart00727
      Location:309 → 348
      STI1; Heat shock chaperonin-binding motif
      cd14438
      Location:3 → 43
      Hip_N; N-terminal dimerization domain of the Hsp70-interacting protein (Hip) and similar proteins
      sd00006
      Location:137 → 167
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:138 → 170
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:103 → 169
      TPR_11; TPR repeat

    2. NM_003932.5 → NP_003923.2  hsc70-interacting protein isoform 1

      See identical proteins and their annotated locations for NP_003923.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BC121107, BM679025, U17714, Z98048
      Consensus CDS
      CCDS14006.1
      UniProtKB/Swiss-Prot
      O14999, P50502, Q2TU77, Q8NFI4
      UniProtKB/TrEMBL
      A0A140VKA6
      Related
      ENSP00000216218.3, ENST00000216218.8
      Conserved Domains (4) summary
      PLN03088
      Location:114 → 233
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
      cd14438
      Location:3 → 43
      Hip_N; N-terminal dimerization domain of the Hsp70-interacting protein (Hip) and similar proteins
      sd00006
      Location:147 → 177
      TPR; TPR repeat [structural motif]
      pfam17830
      Location:316 → 361
      STI1; STI1 domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      40824535..40856639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      41296730..41328831 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50502.2 GenPept UniProtKB/Swiss-Prot:P50502

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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