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    ZNF677 zinc finger protein 677 [ Homo sapiens (human) ]

    Gene ID: 342926, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF677provided by HGNC
    Official Full Name
    zinc finger protein 677provided by HGNC
    Primary source
    HGNC:HGNC:28730
    See related
    Ensembl:ENSG00000197928 AllianceGenome:HGNC:28730
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 4.4), ovary (RPKM 1.4) and 21 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF677 in Genome Data Viewer
    Location:
    19q13.42
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (53235381..53254873, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (56314896..56334378, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53738634..53758126, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 818, pseudogene Neighboring gene NADH:ubiquinone oxidoreductase core subunit V2 pseudogene 1 Neighboring gene vomeronasal 1 receptor 2 Neighboring gene vomeronasal 1 receptor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. ZNF677 suppresses renal cell carcinoma progression through N6-methyladenosine and transcriptional repression of CDKN3. Li A, et al. Clin Transl Med, 2022 Jun. PMID 35678231, Free PMC Article
    2. Overexpression of zinc-finger protein 677 inhibits proliferation and invasion by and induces apoptosis in clear cell renal cell carcinoma. Liang W, et al. Bioengineered, 2022 Mar. PMID 35164660, Free PMC Article
    3. Loss of ZNF677 expression is a predictive biomarker for lymph node metastasis in Middle Eastern Colorectal Cancer. Siraj AK, et al. Sci Rep, 2021 Nov 16. PMID 34785764, Free PMC Article
    4. Loss of ZNF677 Expression Is an Independent Predictor for Distant Metastasis in Middle Eastern Papillary Thyroid Carcinoma Patients. Siraj AK, et al. Int J Mol Sci, 2021 Jul 22. PMID 34360599, Free PMC Article
    5. ZNF677 downregulation by promoter hypermethylation as a driver event through gastric tumorigenesis. Bidar N, et al. Exp Mol Pathol, 2021 Aug. PMID 34171355

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF677 inhibits oral squamous cell carcinoma growth and tumor stemness by regulating FOXO3a.
      Title: ZNF677 inhibits oral squamous cell carcinoma growth and tumor stemness by regulating FOXO3a.
    2. ZNF677 suppresses renal cell carcinoma progression through N6-methyladenosine and transcriptional repression of CDKN3.
      Title: ZNF677 suppresses renal cell carcinoma progression through N6-methyladenosine and transcriptional repression of CDKN3.
    3. Overexpression of zinc-finger protein 677 inhibits proliferation and invasion by and induces apoptosis in clear cell renal cell carcinoma.
      Title: Overexpression of zinc-finger protein 677 inhibits proliferation and invasion by and induces apoptosis in clear cell renal cell carcinoma.
    4. Loss of ZNF677 expression is a predictive biomarker for lymph node metastasis in Middle Eastern Colorectal Cancer.
      Title: Loss of ZNF677 expression is a predictive biomarker for lymph node metastasis in Middle Eastern Colorectal Cancer.
    5. ZNF677 downregulation by promoter hypermethylation as a driver event through gastric tumorigenesis.
      Title: ZNF677 downregulation by promoter hypermethylation as a driver event through gastric tumorigenesis.
    6. Loss of ZNF677 Expression Is an Independent Predictor for Distant Metastasis in Middle Eastern Papillary Thyroid Carcinoma Patients.
      Title: Loss of ZNF677 Expression Is an Independent Predictor for Distant Metastasis in Middle Eastern Papillary Thyroid Carcinoma Patients.
    7. ZNF677 functions as a tumor suppressor and is frequently silenced via promoter methylation in thyroid cancer
      Title: ZNF677 Suppresses Akt Phosphorylation and Tumorigenesis in Thyroid Cancer.
    8. our results demonstrate that ZNF677 is trancriptionally regulated by methylation in non-small cell lung cancers and suggest that ZNF677 has tumor cell growth suppressing properties
      Title: DNA methylation transcriptionally regulates the putative tumor cell growth suppressor ZNF677 in non-small cell lung cancers.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC48625

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 677
    Names
    hypothetical protein MGC48625

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317998.2 → NP_001304927.1  zinc finger protein 677 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1-3 all encode the same isoform (a).
      Source sequence(s)
      AC092070
      Consensus CDS
      CCDS12861.1
      UniProtKB/Swiss-Prot
      Q86XU0
      Conserved Domains (3) summary
      smart00349
      Location:9 → 59
      KRAB; krueppel associated box
      COG5048
      Location:194 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:265 → 285
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001385608.1 → NP_001372537.1  zinc finger protein 677 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same isoform (a).
      Source sequence(s)
      AC092070
      Consensus CDS
      CCDS12861.1
      UniProtKB/Swiss-Prot
      Q86XU0
      Conserved Domains (3) summary
      smart00349
      Location:9 → 59
      KRAB; krueppel associated box
      COG5048
      Location:194 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:265 → 285
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001385609.1 → NP_001372538.1  zinc finger protein 677 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variant 5, encodes isoform b.
      Source sequence(s)
      AC092070
      Conserved Domains (1) summary
      smart00349
      Location:9 → 56
      KRAB; krueppel associated box

    4. NM_001385610.1 → NP_001372539.1  zinc finger protein 677 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variant 4, encodes isoform b.
      Source sequence(s)
      AC092070
      Conserved Domains (1) summary
      smart00349
      Location:9 → 56
      KRAB; krueppel associated box

    5. NM_001385611.1 → NP_001372540.1  zinc finger protein 677 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variant 7, encodes isoform c.
      Source sequence(s)
      AC092070
      UniProtKB/TrEMBL
      M0R0I7
      Conserved Domains (1) summary
      pfam01352
      Location:9 → 48
      KRAB; KRAB box

    6. NM_001385612.1 → NP_001372541.1  zinc finger protein 677 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variant 6, encodes isoform c.
      Source sequence(s)
      AC092070
      UniProtKB/TrEMBL
      M0R0I7
      Conserved Domains (1) summary
      pfam01352
      Location:9 → 48
      KRAB; KRAB box

    7. NM_001385613.1 → NP_001372542.1  zinc finger protein 677 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 9 and 10, encodes isoform d.
      Source sequence(s)
      AC092070
      Consensus CDS
      CCDS92680.1
      UniProtKB/TrEMBL
      M0QYA4
      Related
      ENSP00000469701.1, ENST00000599012.5
      Conserved Domains (1) summary
      smart00349
      Location:9 → 56
      KRAB; krueppel associated box

    8. NM_001385614.1 → NP_001372543.1  zinc finger protein 677 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variants 8 and 10, encodes isoform d.
      Source sequence(s)
      AC092070
      Consensus CDS
      CCDS92680.1
      UniProtKB/TrEMBL
      M0QYA4
      Conserved Domains (1) summary
      smart00349
      Location:9 → 56
      KRAB; krueppel associated box

    9. NM_001385615.1 → NP_001372544.1  zinc finger protein 677 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 8 and 9, encodes isoform d.
      Source sequence(s)
      AC092070
      Consensus CDS
      CCDS92680.1
      UniProtKB/TrEMBL
      M0QYA4
      Conserved Domains (1) summary
      smart00349
      Location:9 → 56
      KRAB; krueppel associated box

    10. NM_001385616.1 → NP_001372545.1  zinc finger protein 677 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC092070
      UniProtKB/TrEMBL
      M0R0I7
      Conserved Domains (1) summary
      smart00349
      Location:9 → 56
      KRAB; krueppel associated box

    11. NM_001385617.1 → NP_001372546.1  zinc finger protein 677 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC092070
      UniProtKB/TrEMBL
      M0R0I7
      Conserved Domains (1) summary
      pfam01352
      Location:9 → 48
      KRAB; KRAB box

    12. NM_001385618.1 → NP_001372547.1  zinc finger protein 677 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC092070
      UniProtKB/TrEMBL
      M0R0I7
      Conserved Domains (1) summary
      smart00349
      Location:9 → 56
      KRAB; krueppel associated box

    13. NM_182609.4 → NP_872415.1  zinc finger protein 677 isoform a

      See identical proteins and their annotated locations for NP_872415.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same isoform (a).
      Source sequence(s)
      AC092070
      Consensus CDS
      CCDS12861.1
      UniProtKB/Swiss-Prot
      Q86XU0
      Related
      ENSP00000469391.1, ENST00000598513.6
      Conserved Domains (3) summary
      smart00349
      Location:9 → 59
      KRAB; krueppel associated box
      COG5048
      Location:194 → 540
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:265 → 285
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. NR_169728.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC092070

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      53235381..53254873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438761.1 → XP_047294717.1  zinc finger protein 677 isoform X2

      UniProtKB/TrEMBL
      M0R1V2
      Related
      ENSP00000472132.1, ENST00000594681.5

    2. XM_047438762.1 → XP_047294718.1  zinc finger protein 677 isoform X3

      UniProtKB/TrEMBL
      M0R079, M0R0I7
      Related
      ENSP00000471071.1, ENST00000598806.5

    3. XM_047438760.1 → XP_047294716.1  zinc finger protein 677 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      56314896..56334378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320846.1 → XP_054176821.1  zinc finger protein 677 isoform X2

      UniProtKB/TrEMBL
      M0R1V2

    2. XM_054320847.1 → XP_054176822.1  zinc finger protein 677 isoform X3

      UniProtKB/TrEMBL
      M0R079, M0R0I7

    3. XM_054320845.1 → XP_054176820.1  zinc finger protein 677 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86XU0.1 GenPept UniProtKB/Swiss-Prot:Q86XU0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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