STXBP5-AS1 STXBP5 antisense RNA 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: STXBP5-AS1provided by HGNC
Official Full Name: STXBP5 antisense RNA 1provided by HGNC
Primary source: HGNC:HGNC:44183
See related: Ensembl:ENSG00000233452 AllianceGenome:HGNC:44183
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression: Broad expression in brain (RPKM 1.3), bone marrow (RPKM 1.3) and 24 other tissues See more
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Genomic context

Location:: 6q24.3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (146841388..147204614, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (148034620..148397903, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (147162524..147525750, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA STXBP5-AS1 suppresses stem cell-like properties of pancreatic cancer by epigenetically inhibiting neighboring androglobin gene expression.
Title: LncRNA STXBP5-AS1 suppresses stem cell-like properties of pancreatic cancer by epigenetically inhibiting neighboring androglobin gene expression.
Aberrant hypermethylation induced downregulation of antisense lncRNA STXBP5-AS1 and its sense gene STXBP5 correlate with tumorigenesis of glioma.
Title: Aberrant hypermethylation induced downregulation of antisense lncRNA STXBP5-AS1 and its sense gene STXBP5 correlate with tumorigenesis of glioma.
we found a significant SNP-based heritability for self-rated Attention-deficit/hyperactivity disorder (ADHD). The top hit of the genome-wide meta-analysis (SNP rs12661753; p-value = 3.02 x 10(-7)) was present in the long non-coding RNA gene STXBP5-AS1. This association was also observed in a meta-analysis of childhood ADHD symptom scores in eight population-based pediatric cohorts
Title: A Potential Role for the STXBP5-AS1 Gene in Adult ADHD Symptoms.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

RH66550 (e-PCR)
- UniSTS:34306

RH120790 (e-PCR)
- UniSTS:132871

RH121694 (e-PCR)
- UniSTS:134433

D8S2279 (e-PCR)
- UniSTS:473907

D6S1300 (e-PCR)
- UniSTS:80962

RH122957 (e-PCR)
- UniSTS:135254

D6S225 (e-PCR)
- UniSTS:147053

SHGC-142341 (e-PCR)
- UniSTS:171400

RH120668 (e-PCR)
- UniSTS:132749

SHGC-36574 (e-PCR)
- UniSTS:61108

RH119980 (e-PCR)
- UniSTS:133303

Other Names

STXBP5 antisense RNA 1 (non-protein coding)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.