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    C11orf87 chromosome 11 open reading frame 87 [ Homo sapiens (human) ]

    Gene ID: 399947, updated on 10-Dec-2024

    Summary

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    Official Symbol
    C11orf87provided by HGNC
    Official Full Name
    chromosome 11 open reading frame 87provided by HGNC
    Primary source
    HGNC:HGNC:33788
    See related
    Ensembl:ENSG00000185742 AllianceGenome:HGNC:33788
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NEURIM1; LOH11CR1A
    Summary
    Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward brain (RPKM 7.9) See more
    Orthologs
    mouse all
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    Genomic context

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    See C11orf87 in Genome Data Viewer
    Location:
    11q22.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (109422190..109429167)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (109432359..109439336)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (109292916..109299893)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 349 Neighboring gene uncharacterized LOC124900307 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:109261364-109261957 Neighboring gene chaperonin containing TCP1 subunit 6 pseudogene 5 Neighboring gene MPRA-validated peak1462 silencer Neighboring gene long intergenic non-protein coding RNA 2715

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Transcriptome analysis of fibroblasts from schizophrenia patients reveals differential expression of schizophrenia-related genes. Etemadikhah M, et al. Sci Rep, 2020 Jan 20. PMID 31959813, Free PMC Article
    2. Methylomic analysis identifies C11orf87 as a novel epigenetic biomarker for GI cancers. Tran MTMT, et al. PLoS One, 2021. PMID 33886682, Free PMC Article
    3. Suppression of miR-147b contributed to H37Rv-infected macrophage viability and migration in tuberculosis in vitro. Niu J, et al. Microb Pathog, 2020 Jul. PMID 32179078
    4. Biological insights from 108 schizophrenia-associated genetic loci. Schizophrenia Working Group of the Psychiatric Genomics Consortium. Nature, 2014 Jul 24. PMID 25056061, Free PMC Article
    5. The protein interaction landscape of the human CMGC kinase group. Varjosalo M, et al. Cell Rep, 2013 Apr 25. PMID 23602568

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Methylomic analysis identifies C11orf87 as a novel epigenetic biomarker for GI cancers.
      Title: Methylomic analysis identifies C11orf87 as a novel epigenetic biomarker for GI cancers.
    2. Suppression of miR-147b contributed to H37Rv-infected macrophage viability and migration in tuberculosis in vitro.
      Title: Suppression of miR-147b contributed to H37Rv-infected macrophage viability and migration in tuberculosis in vitro.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ33767

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein C11orf87
    Names
    neuronal integral membrane protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207645.4 → NP_997528.2  uncharacterized protein C11orf87 precursor

      See identical proteins and their annotated locations for NP_997528.2

      Status: VALIDATED

      Source sequence(s)
      AB096240, AK091086, AK303693, BC035798, DA221578, DA232989
      Consensus CDS
      CCDS31672.1
      UniProtKB/Swiss-Prot
      B4E169, Q6NUJ2
      UniProtKB/TrEMBL
      A0A158RFU1
      Related
      ENSP00000331581.6, ENST00000327419.7
      Conserved Domains (1) summary
      pfam06365
      Location:56 → 100
      CD34_antigen; CD34/Podocalyxin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      109422190..109429167
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011542818.3 → XP_011541120.1  uncharacterized protein C11orf87 isoform X2

      See identical proteins and their annotated locations for XP_011541120.1

      UniProtKB/Swiss-Prot
      B4E169, Q6NUJ2
      UniProtKB/TrEMBL
      A0A158RFU1
      Conserved Domains (1) summary
      pfam06365
      Location:56 → 100
      CD34_antigen; CD34/Podocalyxin family

    2. XM_011542817.3 → XP_011541119.1  uncharacterized protein C11orf87 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      109432359..109439336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368764.1 → XP_054224739.1  uncharacterized protein C11orf87 isoform X2

      UniProtKB/Swiss-Prot
      B4E169, Q6NUJ2
      UniProtKB/TrEMBL
      A0A158RFU1

    2. XM_054368763.1 → XP_054224738.1  uncharacterized protein C11orf87 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NUJ2.2 GenPept UniProtKB/Swiss-Prot:Q6NUJ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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