U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    KLHL18 Kelch like family member 18 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41458, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    KLHL18provided by FlyBase
    Official Full Name
    Kelch like family member 18provided by FlyBase
    Primary source
    FLYBASE:FBgn0037978
    Locus tag
    Dmel_CG3571
    See related
    AllianceGenome:FB:FBgn0037978
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.179; CG3571; dKLHL18; Dmel\CG3571
    Summary
    Enables ubiquitin-like ligase-substrate adaptor activity. Involved in imaginal disc fusion, thorax closure and proteasome-mediated ubiquitin-dependent protein catabolic process. Part of Cul3-RING ubiquitin ligase complex. Is expressed in organism. Orthologous to human KLHL18 (kelch like family member 18). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See KLHL18 in Genome Data Viewer
    Location:
    87A4-87A5; 3-51 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12007476..12010434, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7833198..7836156, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene midline fasciclin Neighboring gene Tachykinin Neighboring gene Ectoderm-expressed 3 Neighboring gene GRIP and coiled-coil domain containing 185 kDa Neighboring gene DDB1 and CUL4 associated factor 12 Neighboring gene Spt3

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. BTB protein, dKLHL18/CG3571, serves as an adaptor subunit for a dCul3 ubiquitin ligase complex. Fujiyama-Nakamura S, et al. Genes Cells, 2009 Aug. PMID 19624754
    2. Stability of HIB-Cul3 E3 ligase adaptor HIB Is Regulated by Self-degradation and Availability of Its Substrates. Zhou Z, et al. Sci Rep, 2015 Aug 12. PMID 26263855, Free PMC Article
    3. Genetic link between heme oxygenase and the signaling pathway of DNA damage in Drosophila melanogaster. Ida H, et al. Tohoku J Exp Med, 2013 Oct. PMID 24126234
    4. Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death. Cao C, et al. J Cell Biol, 2007 Mar 12. PMID 17339378, Free PMC Article
    5. Identification and investigation of Drosophila postsynaptic density homologs. Liebl FL, et al. Bioinform Biol Insights, 2008 Nov 3. PMID 19812789, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in imaginal disc fusion, thorax closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Cul3-RING ubiquitin ligase complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    part_of Cul3-RING ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    kelch like family member 18
    Names
    CG3571-PA
    CG3571-PB
    CG3571-PC
    KLHL18-PA
    KLHL18-PB
    KLHL18-PC

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12007476..12010434 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275565.1 → NP_001262494.1  kelch like family member 18, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262494.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VGE5
      Conserved Domains (6) summary
      smart00612
      Location:340 → 386
      Kelch; Kelch domain
      PHA03098
      Location:36 → 510
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:423 → 466
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:29 → 135
      BTB; BTB/POZ domain
      pfam01344
      Location:469 → 514
      Kelch_1; Kelch motif
      pfam07707
      Location:143 → 245
      BACK; BTB And C-terminal Kelch

    2. NM_141886.3 → NP_650143.1  kelch like family member 18, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650143.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VGE5
      Related
      FBpp0082029
      Conserved Domains (6) summary
      smart00612
      Location:340 → 386
      Kelch; Kelch domain
      PHA03098
      Location:36 → 510
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:423 → 466
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:29 → 135
      BTB; BTB/POZ domain
      pfam01344
      Location:469 → 514
      Kelch_1; Kelch motif
      pfam07707
      Location:143 → 245
      BACK; BTB And C-terminal Kelch

    3. NM_169446.2 → NP_731664.1  kelch like family member 18, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731664.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VGE6
      Related
      FBpp0082030
      Conserved Domains (6) summary
      smart00612
      Location:303 → 349
      Kelch; Kelch domain
      PHA03098
      Location:15 → 473
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:386 → 429
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:6 → 98
      BTB; BTB/POZ domain
      pfam01344
      Location:432 → 477
      Kelch_1; Kelch motif
      pfam07707
      Location:106 → 208
      BACK; BTB And C-terminal Kelch
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VGE5 Q9VGE5
    Q9VGE6 Q9VGE6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools