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    Faf2 Fas-associated factor 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35129, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Faf2provided by FlyBase
    Official Full Name
    Fas-associated factor 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0025608
    Locus tag
    Dmel_CG10372
    See related
    AllianceGenome:FB:FBgn0025608
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10372; Dmel\CG10372; Faf; FFAF; GT#49; Ubxd8
    Summary
    Predicted to enable protein-macromolecule adaptor activity and ubiquitin binding activity. Predicted to be involved in ERAD pathway. Predicted to be active in endoplasmic reticulum. Is expressed in adult head and organism. Orthologous to human FAF2 (Fas associated factor family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Faf2 in Genome Data Viewer
    Location:
    37A1-37A1; 2-54 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18706010..18708688, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18706010..18708688, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Jwa Neighboring gene Grip71 Neighboring gene Inwardly rectifying potassium channel 3 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44768

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved unfoldase activity for the p97 AAA-ATPase in proteasomal degradation. Beskow A, et al. J Mol Biol, 2009 Dec 11. PMID 19782090
    2. VCP Machinery Mediates Autophagic Degradation of Empty Argonaute. Kobayashi H, et al. Cell Rep, 2019 Jul 30. PMID 31365860
    3. Caspar, a suppressor of antibacterial immunity in Drosophila. Kim M, et al. Proc Natl Acad Sci U S A, 2006 Oct 31. PMID 17050695, Free PMC Article
    4. Dual-tagging gene trap of novel genes in Drosophila melanogaster. Lukacsovich T, et al. Genetics, 2001 Feb. PMID 11156992, Free PMC Article
    5. Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila. Bilen J, et al. PLoS Genet, 2007 Oct. PMID 17953484, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Fas-associated factor 2
    Names
    CG10372-PA
    CG10372-PB
    Faf2-PA
    Faf2-PB
    Fas-associated factor
    Fly Fas-associated factor
    UBX domain 8 like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18706010..18708688 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299128.1 → NP_001286057.1  Fas-associated factor 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286057.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77047, Q9VJ58
      Conserved Domains (4) summary
      cd02991
      Location:163 → 280
      UAS_ETEA; UAS family, ETEA subfamily; composed of proteins similar to human ETEA protein, the translation product of a highly expressed gene in the T-cells and eosinophils of atopic dermatitis patients compared with those of normal individuals. ETEA shows homology ...
      cd14414
      Location:12 → 49
      UBA_FAF2; UBA-like TAP-C domain found in FAS-associated factor 2 (FAF2) and similar proteins
      cl00155
      Location:373 → 462
      UBQ; Ubiquitin-like proteins
      cl21478
      Location:287 → 373
      ATP-synt_B; ATP synthase B/B' CF(0)

    2. NM_058040.4 → NP_477388.1  Fas-associated factor 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477388.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77047, Q9VJ58
      Related
      FBpp0080670
      Conserved Domains (4) summary
      cd02991
      Location:163 → 280
      UAS_ETEA; UAS family, ETEA subfamily; composed of proteins similar to human ETEA protein, the translation product of a highly expressed gene in the T-cells and eosinophils of atopic dermatitis patients compared with those of normal individuals. ETEA shows homology ...
      cd14414
      Location:12 → 49
      UBA_FAF2; UBA-like TAP-C domain found in FAS-associated factor 2 (FAF2) and similar proteins
      cl00155
      Location:373 → 462
      UBQ; Ubiquitin-like proteins
      cl21478
      Location:287 → 373
      ATP-synt_B; ATP synthase B/B' CF(0)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O77047 O77047
    Q9VJ58 Q9VJ58

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