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    Usp39 Ubiquitin specific protease 39 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32881, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Usp39provided by FlyBase
    Official Full Name
    Ubiquitin specific protease 39provided by FlyBase
    Primary source
    FLYBASE:FBgn0030969
    Locus tag
    Dmel_CG7288
    See related
    AllianceGenome:FB:FBgn0030969
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7288; Dmel\CG7288; Q9VWP1
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be involved in spliceosomal complex assembly. Part of precatalytic spliceosome. Is expressed in organism. Orthologous to human USP39 (ubiquitin specific peptidase 39). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Usp39 in Genome Data Viewer
    Location:
    17F1-17F1; 1-61 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18858203..18860072)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18752236..18754105)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene hat-trick Neighboring gene shopper Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Dorado

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide microarray analysis of TGFbeta signaling in the Drosophila brain. Yang M, et al. BMC Dev Biol, 2004 Oct 8. PMID 15473904, Free PMC Article
    2. In vivo Structure/Function analysis of the Drosophila fat facets deubiquitinating enzyme gene. Chen X, et al. Genetics, 2000 Dec. PMID 11102377, Free PMC Article
    3. The deubiquitinating enzyme DUBAI stabilizes DIAP1 to suppress Drosophila apoptosis. Yang CS, et al. Cell Death Differ, 2014 Apr. PMID 24362437, Free PMC Article
    4. USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization. Xia R, et al. PLoS Biol, 2012 Jan. PMID 22253573, Free PMC Article
    5. Proapoptotic function of deubiquitinase DUSP31 in Drosophila. Sinenko SA. Oncotarget, 2017 Sep 19. PMID 29050293, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables cysteine-type deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosomal complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    ubiquitin specific protease 39
    Names
    CG7288-PA
    Usp39-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18858203..18860072
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_133106.3 → NP_573334.1  ubiquitin specific protease 39 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573334.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RE2, Q9VWP1
      Related
      FBpp0074414
      Conserved Domains (2) summary
      cd02669
      Location:39 → 488
      Peptidase_C19M; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:158 → 487
      UCH; Ubiquitin carboxyl-terminal hydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWP1 Q9VWP1

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