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    Trf4-2 Topoisomerase related function 4-2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42983, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trf4-2provided by FlyBase
    Official Full Name
    Topoisomerase related function 4-2provided by FlyBase
    Primary source
    FLYBASE:FBgn0039251
    Locus tag
    Dmel_CG17462
    See related
    AllianceGenome:FB:FBgn0039251
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAF56369; CG17462; Dmel\CG17462; DmTRF4-2
    Summary
    Predicted to enable poly(A) RNA polymerase activity. Predicted to be involved in RNA 3'-end processing; nuclear polyadenylation-dependent ncRNA catabolic process; and polyadenylation-dependent ncRNA catabolic process. Predicted to be part of TRAMP complex. Predicted to be active in nucleolus. Is expressed in organism and spermatozoon. Orthologous to human TENT4A (terminal nucleotidyltransferase 4A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Trf4-2 in Genome Data Viewer
    Location:
    96B9-96B9; 3-86 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24925216..24927085)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20750938..20752807)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46097 Neighboring gene Mitotic spindle and nuclear protein Neighboring gene uncharacterized protein Neighboring gene Oxysterol binding protein Neighboring gene slingshot

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of miRNA Tailing by 3' Terminal Uridylyl Transferases in Metazoa. Modepalli V, et al. Genome Biol Evol, 2017 Jun 1. PMID 28633361, Free PMC Article
    2. Eukaryotic DNA polymerases: proposal for a revised nomenclature. Burgers PM, et al. J Biol Chem, 2001 Nov 23. PMID 11579108
    3. Drosophila suppressor of sable protein [Su(s)] promotes degradation of aberrant and transposon-derived RNAs. Kuan YS, et al. Mol Cell Biol, 2009 Oct. PMID 19687295, Free PMC Article
    4. Identification of ALK in Thinness. Orthofer M, et al. Cell, 2020 Jun 11. PMID 32442405
    5. TRF4 is involved in polyadenylation of snRNAs in Drosophila melanogaster. Nakamura R, et al. Mol Cell Biol, 2008 Nov. PMID 18765642, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables poly(A) RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) RNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear polyadenylation-dependent ncRNA catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in polyadenylation-dependent ncRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of TRAMP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    topoisomerase related function 4-2
    Names
    CG17462-PA
    CG17462-PB
    Trf4-2-PA
    Trf4-2-PB
    NP_001262941.1
    NP_651313.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24925216..24927085
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143056.3 → NP_651313.1  topoisomerase related function 4-2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651313.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VC07
      Related
      FBpp0084094
      Conserved Domains (2) summary
      cd05402
      Location:52 → 161
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:221 → 280
      PAP_assoc; Cid1 family poly A polymerase

    2. NM_001276012.1 → NP_001262941.1  topoisomerase related function 4-2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262941.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VC07
      Conserved Domains (2) summary
      cd05402
      Location:52 → 161
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:221 → 280
      PAP_assoc; Cid1 family poly A polymerase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VC07.1 Q9VC07

    Gene LinkOut

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