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    Pde6 Phosphodiesterase 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41760, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Pde6provided by FlyBase
    Official Full Name
    Phosphodiesterase 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0038237
    Locus tag
    Dmel_CG8279
    See related
    AllianceGenome:FB:FBgn0038237
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8279; Dmel\CG8279; DmPDE5/6; DmPDE6; PDE5/6; PDE6
    Summary
    Enables 3',5'-cyclic-GMP phosphodiesterase activity. Involved in cGMP metabolic process and negative regulation of nucleobase-containing compound transport. Located in apical plasma membrane. Is expressed in adult head and adult main segment of Malpighian tubule. Human ortholog(s) of this gene implicated in IgA glomerulonephritis and cone-rod dystrophy. Orthologous to human PDE5A (phosphodiesterase 5A) and PDE6C (phosphodiesterase 6C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pde6 in Genome Data Viewer
    Location:
    88C3-88C6; 3-55 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14513901..14558304, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10339623..10384026, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene HTRA2-related serine protease Neighboring gene mitochondrial ribosomal protein L11 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 313a1 Neighboring gene long non-coding RNA:CR46021 Neighboring gene long non-coding RNA:CR46022 Neighboring gene long non-coding RNA:CR46023 Neighboring gene uncharacterized protein Neighboring gene Jig

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel role for a Drosophila homologue of cGMP-specific phosphodiesterase in the active transport of cGMP. Day JP, et al. Biochem J, 2006 Jan 15. PMID 16232123, Free PMC Article
    2. Regulation of a Drosophila melanogaster cGMP-specific phosphodiesterase by prenylation and interaction with a prenyl-binding protein. Day JP, et al. Biochem J, 2008 Sep 15. PMID 18503409
    3. Cyclic nucleotide phosphodiesterases in Drosophila melanogaster. Day JP, et al. Biochem J, 2005 May 15. PMID 15673286, Free PMC Article
    4. White - cGMP Interaction Promotes Fast Locomotor Recovery from Anoxia in Adult Drosophila. Xiao C, et al. PLoS One, 2017. PMID 28060942, Free PMC Article
    5. Visual Working Memory Requires Permissive and Instructive NO/cGMP Signaling at Presynapses in the Drosophila Central Brain. Kuntz S, et al. Curr Biol, 2017 Mar 6. PMID 28216314

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Drosophila genome encodes five novel PDE genes in addition to dunce. Predicted PDE sequences of Drosophila show highly conserved critical domains when compared with human PDEs.
      Title: Cyclic nucleotide phosphodiesterases in Drosophila melanogaster.
    2. Regulation of a Drosophila melanogaster cGMP-specific phosphodiesterase-5/6 (DmPDE5/6) by prenylation and interaction with a prenyl-binding protein.
      Title: Regulation of a Drosophila melanogaster cGMP-specific phosphodiesterase by prenylation and interaction with a prenyl-binding protein.
    3. The first demonstration of a novel role for a cG-PDE in modulating cGMP transport and efflux in D. melanogaster Malphigian tubules is presented.
      Title: A novel role for a Drosophila homologue of cGMP-specific phosphodiesterase in the active transport of cGMP.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of nucleobase-containing compound transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphodiesterase 6
    Names
    CG8279-PB
    CG8279-PC
    CG8279-PD
    Pde6-PB
    Pde6-PC
    Pde6-PD
    NP_001262566.1
    NP_001287327.1
    NP_650369.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      14513901..14558304 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142112.5 → NP_650369.3  phosphodiesterase 6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650369.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95TW8, Q9VFI9
      UniProtKB/TrEMBL
      A0A0B4LH87
      Conserved Domains (2) summary
      smart00065
      Location:247 → 406
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:717 → 950
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    2. NM_001275637.2 → NP_001262566.1  phosphodiesterase 6, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262566.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFZ3
      Conserved Domains (2) summary
      smart00065
      Location:247 → 406
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:717 → 950
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    3. NM_001300398.1 → NP_001287327.1  phosphodiesterase 6, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287327.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95TW8, Q9VFI9
      UniProtKB/TrEMBL
      A0A0B4LH87
      Conserved Domains (2) summary
      smart00065
      Location:247 → 406
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:717 → 950
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFZ3 A0A0B4KFZ3
    A0A0B4LH87 A0A0B4LH87
    Q9VFI9.4 Q9VFI9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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